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Name : leuS (NMB1897) Accession : NP_274892.1 Strain : Neisseria meningitidis MC58 Genome accession: NC_003112 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 1995949 - 1998579 bp Length : 2631 bp Strand : - Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGCAAGAACAATACCGGCCCGCCGCCATTGAGCCTGCGGCGCAGAAAAAATGGGACGACGCCCGTATTTTCAACGTCTC CGAAGACGCTTCCAAACCCAAATATTATTGCCTCTCCATGTTCCCCTATCCCAGCGGCAAGCTGCACATGGGGCATGTGC GCAACTACACCATCGGCGATGTATTGAGCCGCTTCAAACTTTTAAACGGCTTCAACGTCATGCAGCCTATGGGTTGGGAC GCGTTCGGCATGCCGGCGGAAAACGCGGCGATGAAAAACAACGTCGCCCCTGCCGCTTGGACGTACGATAACATCGAATA CATGAAAACCCAGCTCAAAAGCCTAGGTTTTGCGATTGACTGGGCGCGCGAAACCGCAACCTGCAAACCCGAATACTACC GCTGGGAACAATGGCTGTTTACCAAGCTGTTTGAAAAAGGCATCGTTTATCGCAAAAACGGCACGGTAAACTGGGACCCT GTCGACCAAACCGTCCTTGCCAACGAGCAAGTCATCGACGGACGCGGCTGGCGTTCCGGCGCATTGATCGAAAAACGCGA AATCCCGATGTATTACTTCAAAATCACGGATTACGCCGAAGAGCTGCTCAACGACTTGGACAAGCTGGAACACTGGCCGG AACAAGTCAAAACCATGCAGCGCAACTGGATCGGCAAATCGCGCGGTATGACCGTGCGCTTCGCCGTTTCAGACGACAGC AAACAAGGCTTGGAAGGCGATTACGCGAAATTCCTGCAAGTTTATACCACCCGCCCCGACACGCTGATGGGTGCGACTTA TGTTGCCGTTGCCGCCGAGCATCCGCTGGCAGCCGCCGCAGCCGCCGACAAACCCGAATTGCAGGCATTTATTGCCGAAT GCAAAGCCGGTTCGGTTGCCGAAGCCGATATGGCGACGATGGAGAAAAAAGGCGTGCCGACCGGCCGCTACGTCGTCAAC CCGCTCAACGGCGACAAGCTGGAAGTGTGGATTGCCAACTATGTATTGTGGGGCTACGGCGACGGCGCGGTGATGGCGGT TCCGGCGCACGACGAACGCGATTTTGAGTTCGCCACCAAATACAATCTGCCGAAAAAACAAGTCATTGCCGTCGGCGACA ACGCATTTGACGAAAACCAATGGCAAGAATGGTACGGCGACAAAGAAAACGGCGTATTGGTCAACAGCGGCGACTTGGAC GGCTTGGATTTTCAGACGGCATTCGACGCCGTCGCCGCCAAGCTGCAAAGCCAAGGCGCGGGCGAACCGAAAACCCAATA CCGCCTGCGCGACTGGGGCATTTCGCGCCAACGCTACTGGGGCTGCCCGATTCCCATCGTCCATTGCGAACAATGCGGCG ACGTACCCGTCCCTGCCGACCAATTGCCGGTCGTTTTGCCTGAAAACGTCGTACCCGACGGCATGGGTTCGCCGCTGGCA AAAATGCCCGAGTTTTACGAAACTGCCTGCCCATGCTGCGGCGGCGCGGCGAAACGCGAAACCGACACCATGGACACCTT CATGGAATCGAGCTGGTATTTCTTCCGCTACATGTCGCCAAAATTTTCAGACGGCATGGTCGATCCTGCCGCCGCGAAAT ACTGGGGCGCGGTCGACCAATACATCGGCGGCATCGAACACGCGATTTTGCACCTCTTGTACGCGCGTTTCTTCACCAAA CTGATGCGCGACGAAGGTCTAGTCAATGTTGACGAACCGTTTGAACGCCTGCTGACGCAAGGCATGGTCGTTTGCGAAAC CTACTACCGCGAAAACGACAAAGGCGGCAAAGATTGGATCAACCCCGCCGATGTCGAGCTGACGTTCGACGACAAAGGCC GCCCCATTTCCGCCGTCCTCAAAGCCGACGGGCTGCCCGTCGTCATCAGCGGCACGGAAAAAATGTCCAAGTCCAAAAAC AACGGCGTCGATCCGCAAGAACTGATTAACGCCTACGGCGCGGACACCGCCCGCCTGTTTATGATGTTCGCCGCACCGCC CGAACAGTCCCTCGAATGGAGCGACAGCGGCGTCGAAGGCGCACACCGCTTCCTGCGCCGCCTGTGGCGTACCGTTTACG AATACTTGAAGCAAGGCGAAGCGGTCAAAGCGTTCGCAGGCAGCCAAGACGGTTTGTCTAAAGAACTCAAAGACCTGCGC CACAAACTGCACGCGACCACTGCCAAAGTCAGCGACGACTACGGCCGCCGCCAGCAGTTCAACACCGCCATCGCCGCCGT GATGGAATTGCTCAACCAATACGACAAAACCGACACCGGCGGCGAACAAGGACGCGCCGTCGCCCAAGAAGTATTGGAAA CCGCCGTACGCCTGTTGTGGCCCATCGTGCCGCACATCTGCGAAACCCTGTGGAGCGAATTGAACGGCGCGAAACTGTGG GAAGCAGGCTGGCCGACAGTCGACGAAGCCGCCTTGGTCAAATCCGAAATCGAAGTGATGGTTCAAGTCAACGGCAAACT GCGCGGCAAAATCACTGTTGCCGCCGACGCATCCAAAGCCGACCTCGAAGCCGCCGCACTCGCCACCGAAGGCGCGGTGA AATTCATGGAAGGCAAACCGGCGAAGAAAATCATCGTCGTACCGGGCAGACTGGTGAACATCGTCGTCTAA Protein sequence : MQEQYRPAAIEPAAQKKWDDARIFNVSEDASKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRFKLLNGFNVMQPMGWD AFGMPAENAAMKNNVAPAAWTYDNIEYMKTQLKSLGFAIDWARETATCKPEYYRWEQWLFTKLFEKGIVYRKNGTVNWDP VDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITDYAEELLNDLDKLEHWPEQVKTMQRNWIGKSRGMTVRFAVSDDS KQGLEGDYAKFLQVYTTRPDTLMGATYVAVAAEHPLAAAAAADKPELQAFIAECKAGSVAEADMATMEKKGVPTGRYVVN PLNGDKLEVWIANYVLWGYGDGAVMAVPAHDERDFEFATKYNLPKKQVIAVGDNAFDENQWQEWYGDKENGVLVNSGDLD GLDFQTAFDAVAAKLQSQGAGEPKTQYRLRDWGISRQRYWGCPIPIVHCEQCGDVPVPADQLPVVLPENVVPDGMGSPLA KMPEFYETACPCCGGAAKRETDTMDTFMESSWYFFRYMSPKFSDGMVDPAAAKYWGAVDQYIGGIEHAILHLLYARFFTK LMRDEGLVNVDEPFERLLTQGMVVCETYYRENDKGGKDWINPADVELTFDDKGRPISAVLKADGLPVVISGTEKMSKSKN NGVDPQELINAYGADTARLFMMFAAPPEQSLEWSDSGVEGAHRFLRRLWRTVYEYLKQGEAVKAFAGSQDGLSKELKDLR HKLHATTAKVSDDYGRRQQFNTAIAAVMELLNQYDKTDTGGEQGRAVAQEVLETAVRLLWPIVPHICETLWSELNGAKLW EAGWPTVDEAALVKSEIEVMVQVNGKLRGKITVAADASKADLEAAALATEGAVKFMEGKPAKKIIVVPGRLVNIVV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 4e-138 | 41 |
