Gene Information

Name : smpB (NMB1526)
Accession : NP_274533.1
Strain : Neisseria meningitidis MC58
Genome accession: NC_003112
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 1576673 - 1577119 bp
Length : 447 bp
Strand : -
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCTATTGCGAACAATAAAAAAGCATTTCACGATTTTTTCATTGAAGACCGGATTGAAGCCGGTTTGGTCTTGGAAGG
CTGGGAAGTCAAAGCAATCCGCGCCGCGCGCGTACAGCTTAAAGAGAGTTATATCTATTGGAAAAAAGACGCGTTTTATC
TGGTCGGCTGCCATATTACGGCTTTGCCCACAGCCTCGACACACATTAAACCAGATGCCGTACGTCCGCGCAAGCTCTTG
TTGAACCAGTCGGAAATCAACAAATTAATCGGCAAAACCGAACGTGCCGGCTACACCATCGTGCCGCTGGATTTGCATTT
TTCACGCGGAAAAATCAAGATGGAAATCGGTTTGGCAAAAGGTAAGAAACAGCACGACAAACGCCAGAGTATGAAAGAGG
CGGATTGGAAACGCGAGAAACAGCGGTTGATTAAGCATACGCGCTGA

Protein sequence :
MAIANNKKAFHDFFIEDRIEAGLVLEGWEVKAIRAARVQLKESYIYWKKDAFYLVGCHITALPTASTHIKPDAVRPRKLL
LNQSEINKLIGKTERAGYTIVPLDLHFSRGKIKMEIGLAKGKKQHDKRQSMKEADWKREKQRLIKHTR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 6e-31 47
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 5e-23 46
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 7e-15 42