Gene Information

Name : serS (RC1216)
Accession : NP_360853.1
Strain : Rickettsia conorii Malish 7
Genome accession: NC_003103
Putative virulence/resistance : Unknown
Product : seryl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0172
EC number : 6.1.1.11
Position : 1115909 - 1117186 bp
Length : 1278 bp
Strand : +
Note : catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
ATGTTAAATATCAAATGGATTAGAGAAAATAAAGAATTGTTCGATGAAAAGCTTAGCCAAAGATTTATTGAACCTATGTC
TAGTAAAATTGCTATGCTCGACGGAGAGAAAAGAAAAATTACGAGTTTAATTCAAGAATTTCAGCATGCACGTAAGGTAA
AATCAAAGATTTTAGGTAATATGGCCTCTAAAAGCGGCGAAGAATTTGAAGGGTTACAAAGAGATGTCAAACATATAAAT
GAGAAGTTGGAAGCACTTGAACAGGATCTAAATAATAATAACGAATTAAATGAACTATTAAATATGTTTCCTAATATTCC
GGACGACGAAGTACCTTACGGAATGGATGAAAGTATGAATAAATTAGTTCGTACTTACGGAGAGACAAATCCAAATGCTT
TGAATAAACAGCATTTTGAACTAGGTATAAAATTAAATTTAATGGATTTTGAACAAACTGCTAAAATTTCTGGAACTAGA
TTTGTAACGTTAAAAGGTGATTTAGCAAAGCTAGAACGTGCTTTAATTAATTTTATGATTGATGTTCATACTAAAGAGTG
GGATTTCTTTGAGATATCACCTCCGGTATTAGTTCGAGATAATGCTATGTATAATGCAGGACAACTACCTAAATTTGCCG
AAGAGTCTTTTGCAACAACCAATGGTTACAGACTAATTCCAACCGCAGAAGTATCTTTAGTAAATATGGTCGCCGATACT
ATTATACCAAGAGAAAAATTACCGATACGTTATGTTGCTTACACCCCGTGCTTTAGATCAGAAGCAGGTAGTAGCGGTAG
AGATACAAGAGGTATGATTAGATTACATCAGTTCGGTAAAGTTGAGCTAGTATCTATTACTACCCCTGAAGAATCAACAA
ATGAGCATGAATATATAACTAATGCATCAGAGACTATTTTACAAAAACTGAATCTTCCTTATCGTGTTATGTTACTTTGC
ACCGGAGATATGGGATTTGCGGCAAAAAAAACCTATGATATAGAAGTATGGCTTCCGGGACAAAAGCAATATCGCGAAAT
TGCTAGCTGTTCTAATTGTGGAGATTTTCAAGCACGTAGAATGAAAGCAAGATATAAAGAATTCGGCAGTAACGAAACTA
CCTTAGTTCATACTTTAAATGCTTCAGGATTACCTATCGGAAGAACTATGGTTGCAATACTTGAAAATTATCAGAATGAA
GATGGATCAATAACTATACCGGATGTCTTGATAAATTACATGGGAGGATTACAAAAAATCATTGCCTATAGTGAATAA

Protein sequence :
MLNIKWIRENKELFDEKLSQRFIEPMSSKIAMLDGEKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEGLQRDVKHIN
EKLEALEQDLNNNNELNELLNMFPNIPDDEVPYGMDESMNKLVRTYGETNPNALNKQHFELGIKLNLMDFEQTAKISGTR
FVTLKGDLAKLERALINFMIDVHTKEWDFFEISPPVLVRDNAMYNAGQLPKFAEESFATTNGYRLIPTAEVSLVNMVADT
IIPREKLPIRYVAYTPCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESTNEHEYITNASETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEVWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKIIAYSE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
serS YP_003446791.1 seryl-tRNA synthetase Not tested The aminoglycoside resistance gene cluster Protein 2e-79 46