Gene Information

Name : hemC (RC0706)
Accession : NP_360343.1
Strain : Rickettsia conorii Malish 7
Genome accession: NC_003103
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 679120 - 680175 bp
Length : 1056 bp
Strand : +
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence : 
ATGACAAATTCTATCAGAATAGGTACAAGAAAAAGTCCACTTGCTTTAATACACACTAATTTAGTTATTCAGCAAATCAA
ACAATTTTTTCCTGATATCAATTGTGAAATAGTGCCGATTATTACTAGCGGGGATTTAATCCAAAATAAACCATTATACG
ATATAGGCGGTAAAGCTTTATTTTTAAAGGAAATAGAGCAAGCCTTGCTTGATAAAAAAATTGACTTAGCTGTTCATTCT
TTAAAAGATGTACCGGGTAGAATGCCTGAACCGCTAGTAATAGCTGCTGTTTTAGAGCGTGAAGACCCCAGAGATGTTTT
TGTTTGTCTAAAATATAAATCTATAGAAGAGCTGCCGCAAAATGCCGTAATAGGTAGCTCGGCAGTACGAAGAAAAGCAT
TTATCCAAAAAATAAGACCGGATTTAAAGGTAACGGTTTTTAGAGGGAATGTTGATTCAAGAATAAAAAAGCTAATGACC
GGCGAAGTTGACGCAACAATTTTAGCATATACAGGTCTTAAAAGGTTAGAGGTGTTTAATCCGGAGTATTGCCATTTGAT
AGAGTATTCACAGATGTTACCGTGTATAGGGCAGGGAGTCATTGCAGTTGAGATTAGAAAAGATGATAATGCTATGCTTG
AGATATGCAACCAAATTAATCATCTTCCCACTTTTGAACTCATAAAACCCGAAAGAGCATTTTTAGAGTATCTAGATGCT
AATTGCCGCACCCCGATTGCTGCTTATTCACAATATCTAGATGCAAATCCTAGACATCTTTCCAAACTCGCTTATAGGGA
GGTACTTGAAGGAAACACAGAAGCACTTGCCACCGCAGCGTACAAAAGCAATCGCACAGATGCAAGTACCGGATTGACGT
ACAAATTACCCCTAGAAGTAGAGTTTGGGAAGGTGTCTAATATACAAACCAATTTTATGCTCGGTAACCTTGACGGCAGT
AAAATAACTTTCCATACCGAAACTACCAATATAAAAACTTCAACAGAAGCAGGCATAAAAGCCGCTAAAATGATGTTGGA
AGCTATCTGTAAATAA

Protein sequence : 
MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHS
LKDVPGRMPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQNAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMT
GEVDATILAYTGLKRLEVFNPEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA
NCRTPIAAYSQYLDANPRHLSKLAYREVLEGNTEALATAAYKSNRTDASTGLTYKLPLEVEFGKVSNIQTNFMLGNLDGS
KITFHTETTNIKTSTEAGIKAAKMMLEAICK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 1e-46 45
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 1e-46 45