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Name : guaA (spr1300) Accession : NP_358893.1 Strain : Streptococcus pneumoniae R6 Genome accession: NC_003098 Putative virulence/resistance : Unknown Product : GMP synthase Function : - COG functional category : F : Nucleotide transport and metabolism COG ID : COG0519 EC number : 6.3.5.2 Position : 1292606 - 1294168 bp Length : 1563 bp Strand : - Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway DNA sequence : ATGAGCAACATTTCAACTGATTTGCAAGATGTAGAAAAAATCATCGTATTGGACTATGGTAGCCAGTACAACCAGCTGAT TTCACGCCGTATCCGTGAGATTGGTGTTTTTTCAGAACTAAAAAGCCATAAAATTTCAGCTGCTGAAGTTCGTGAAGTCA ATCCTGTAGGAATTATTCTATCAGGTGGTCCAAATTCTGTATATGAAGATGGTTCATTTGATATTGACCCAGAAATCTTC GAACTCGGAATTCCAATTTTGGGAATCTGTTATGGTATGCAGTTATTGACCCATAAACTTGGAGGAAAAGTTGTTCCTGC AGGTGATGCTGGAAATCGTGAATACGGTCAATCAACCCTAACTCACACACCATCAGCGCTTTTTGAATCAACACCTGATG AACAGACTGTTTTGATGAGCCATGGTGATGCGGTTACTGAGATTCCTGCTGACTTTGTTCGTACAGGTACATCAGCTGAC TGCCCATACGCAGCCATCGAAAACCCAGATAAACACATTTACGGTATCCAATTCCACCCAGAAGTTCGTCATTCTGTATA CGGAAATGATATCCTTCGTAACTTTGCCCTTAACATTTGTAAGGCTAAAGGTGACTGGTCAATGGATAATTTCATTGACA TGCAGATCAAAAAAATTCGTGAAACCGTCGGTGATAAACGTGTCCTTCTTGGTCTATCAGGTGGTGTTGACTCATCTGTC GTTGGGGTTCTTCTCCAAAAAGCGATTGGCGATCAATTGATCTGTATCTTCGTAGACCACGGTCTTCTTCGTAAAGGCGA AGCTGATCAAGTTATGGACATGCTCGGTGGTAAGTTTGGTTTGAATATCGTCAAAGCAGACGCTGCTAAACGTTTCCTTG ACAAACTTGCTGGCGTTTCTGATCCTGAACAAAAACGTAAAATCATTGGTAACGAGTTTGTCTATGTATTCGATGACGAA GCAAGCAAGCTCAAAGATGTGAAATTCCTTGCTCAAGGTACTTTATATACAGATGTTATCGAGTCTGGTACGGATACAGC TCAAACTATCAAGTCACACCACAACGTGGGTGGTCTTCCAGAAGATATGCAGTTTGAATTGATTGAACCACTCAATACTC TTTACAAGGATGAAGTTCGTGCTCTTGGTACAGAGCTTGGTATGCCAGACCATATCGTATGGCGCCAACCATTCCCAGGA CCAGGACTTGCTATCCGTGTCATGGGTGAAATCACTGAAGAGAAACTTGAAACCGTTCGTGAATCAGACGCTATTCTTCG TGAAGAAATCGCTAAAGCTGGACTTGACCGCGATATTTGGCAATACTTCACTGTTAACACAGGCGTTCGTTCAGTCGGTG TTATGGGTGACGGTCGTACGTATGACTACACGATTGCAATCCGTGCTATCACTTCTATCGATGGTATGACTGCTGATTTT GCCAAAATTCCATGGGAAGTACTTCAAAAAATCTCAGTACGTATCGTAAATGAAGTGGATCATGTTAACCGTATCGTCTA CGATATTACAAGTAAACCACCTGCAACAGTTGAGTGGGAGTAA Protein sequence : MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIF ELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD CPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSV VGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDE ASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPG PGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF AKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| SAMSHR1132_03620 | YP_005324884.1 | GMP synthase | Not tested | vSa¥á | Protein | 1e-176 | 71 |
| guaA | YP_001331415.1 | GMP synthase | Not tested | vSa¥á | Protein | 2e-176 | 71 |
| SAPIG0468 | YP_005733278.1 | GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) | Not tested | SAPI-S0385 | Protein | 2e-176 | 71 |
| guaA | NP_938969.1 | GMP synthase | Not tested | Not named | Protein | 1e-122 | 51 |
