Gene Information

Name : nrdE (spr1065)
Accession : NP_358659.1
Strain : Streptococcus pneumoniae R6
Genome accession: NC_003098
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 1062287 - 1064446 bp
Length : 2160 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGGGATTAAAACATCTTGAAGACGTGACTTACTTCCGTCTTAATAACGAAATTAACCGTCCTGTTAATGGACAAATCAT
GCTTCATAAAGACAAGGAAGCCTTGGATGCTTTCTTTAAAGAAAATGTAGTTCCAAACACTATGGTTTTTGATTCAATCA
AAGACAAAATCAATTACCTCATTGAACACAACTACATCGAAACAGCCTTTATCAAGAAATACCGTCCAGAGTTCTTGGAA
GAATTAGCTCAATTTATCAAAGACCAAAACTTCCAATTCAAGTCATTCATGGCAGCTTATAAATTTTACAATCAATATGC
CTTAAAGACTAATGACGGTGAATACTATCTTGAAAATATGGAAGACCGTGTCTTCTTCAACGCCCTTTATTTCGCTGATG
GGAATGAAGCTGTTGCAATCGATATTGCCAATGAAATCATCCACCAACGCTACCAACCTGCTACTCCTTCCTTCTTGAAT
GCTGGACGTGCTCGCCGTGGAGAGTTGGTATCTTGTTTCCTAATCCAAGTGACGGATGATATGAACTCTATCGGACGTTC
TATCAACTCAGCTCTTCAACTTTCACGTATTGGTGGTGGTGTGGGAATTACCCTCAGCAACCTTCGTGAAGCTGGTGCAC
CTATCAAAGGCTATGAAGGAGCTGCTTCAGGTGTCGTTCCTGTTATGAAGCTTTTTGAAGACAGCTTCTCTTACTCCAAC
CAATTGGGGCAACGTCAAGGTGCCGGTGTTGTCTACCTCAACGTCTTTCACCCAGATATCATCGCTTTCCTTTCAACTAA
GAAAGAAAACGCTGATGAAAAAGTACGTGTCAAGACTCTATCACTTGGTGTTGTAGTACCTGATAAATTCTACGAATTGG
CTCGTAAAAATGAAGAAATGTACCTCTTCAGCCCTTACTCTGTAGAAAAAGAATACGGTGTGCCATTCAATTACATCGAC
ATTACTGAAAAATACGATGAATTGGTCGCAAATCCAAATATTCGCAAGACAAAAATCAAGGCGCGGGATTTGGAAACTGA
AATCTCTAAATTGCAACAAGAGTCTGGCTATCCTTATGTAGTCAACATCGATACGGCTAACCGTGCAAATCCTGTTGATG
GAAAGATTATCATGAGTAACTTGTGTTCTGAGATTCTTCAAGTTCAAGAACCAAGCTTGATCAACGATGCTCAAGAATTC
CTTCAAATGGGAACAGATGTTTCATGTAACCTGGGTTCAACCAACGTGGTTAACATGATGACTTCACCTGATTTTGGTCG
TTCTATCCGTGCTATGGTTCGTGCCCTTACTTTCGTTACAGATAGTTCACATATCGTAGCTGTACCAACGATTGACCATG
GAAATAGCCAAGCCCACACCTTTGGTCTCGGTGCCATGGGACTGCACAGCTACCTTGCCCAACAACTCATTGAATATGGT
TCACCTGAGTCTGTTGAATTTACAAGCATCTACTTTATGCTTATGAACTACTGGACCTTGGTAGAGTCAAACAATATTGC
GCGTGAACGTGGTATTACCTTCCACAACTTTGAAAAATCAGACTATGCTAACGGAAGTTACTTTGACAAGTATGTAACTG
GTGAATTTGTTCCAACATCAGACCGTGTTAAAGAACTCTTCAAAAATGTCTTTATCCCTGGTGTTGCTGATTGGGCTGAA
CTTCGCGACAAGGTTCAAGAAGATGGTCTTTACCACCAAAATCGCCTTGCTGTAGCGCCAAATGGTTCTATCAGCTATAT
CAACGACGTTTCTGCTTCTATCCACCCGATTACGCAACGTATCGAAGAACGCCAAGAGAAGAAAATTGGTAAAATCTACT
ACCCTGCTGCTGGCTTGTCTACAGAAACCATTCCTTACTACACTTCTGCCTACGATATGGATATGCGTAAAGTCATCGAT
GTTTACGCTGCTGCGACTGAACACGTGGATCAAGGACTTTCACTCACCCTCTTCATGCGTAGTGACATTCCAAAAGGCCT
TTACGAATGGAAGAGGGAAAATAAACAAACGACACGTGACTTGTCCATCCTTCGTAACTATGCCTTTAACAAGGGAATCA
AGTCTATCTACTACGTCCGTACCTTTACAGATGACGGTGGAGAAGTCGGCGCCAACCAATGTGAAAGCTGTGTGATTTAG

Protein sequence :
MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVVPNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLE
ELAQFIKDQNFQFKSFMAAYKFYNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLN
AGRARRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYEGAASGVVPVMKLFEDSFSYSN
QLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVRVKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYID
ITEKYDELVANPNIRKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPVDGKIIMSNLCSEILQVQEPSLINDAQEF
LQMGTDVSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPTIDHGNSQAHTFGLGAMGLHSYLAQQLIEYG
SPESVEFTSIYFMLMNYWTLVESNNIARERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELFKNVFIPGVADWAE
LRDKVQEDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETIPYYTSAYDMDMRKVID
VYAAATEHVDQGLSLTLFMRSDIPKGLYEWKRENKQTTRDLSILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 3e-178 52