Gene Information

Name : guaA (SMc00394)
Accession : NP_384420.1
Strain : Sinorhizobium meliloti 1021
Genome accession: NC_003047
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 343959 - 345521 bp
Length : 1563 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCCAGACAGCCCATCCCGATACCGTCCTCATCGTCGATTTCGGCAGCCAGGTGACGCAGCTCATCGCCCGGCGCGT
GCGCGAATCCGGCGTCTATTGCGAGATCGTGCCGTTCCAGTCGGCCGAGGAAGGCTTCCATCGTCTGAAGCCGAAGGCGG
TGATCCTGTCCGGCAGCCCGGCCTCGACGCTGGATACCGGCTCGCCCCGCGCGCCCTCCGTCATCTTCGACAGCGGCCTG
CCGGTCTTCGGCATCTGCTACGGCCAGCAGACCATGTGCGCCCAGCTCGGCGGCAAGGTCGAGAGCGGCCATCACCGGGA
ATTCGGCCGGGCCTTCCTCGAGGTCGAAAAGGATTGCCCGCTCTTCGACGGCCTCTGGTCGCTCGGTTCGCGCCACCAGG
TGTGGATGTCGCATGGCGACCGGGTTACCGCATTGCCCGAGGGCTTCGAAGTCGTCGCCACCTCGTCCAATGCGCCCTTC
GCCTTCATCGCCGATGAAAAGCGCAAGTACTATGCCGTCCAGTTCCACCCGGAAGTGGTGCATACGCCTGACGGCGCGAA
GCTCATCGCCAACTTCGTCCACAAGATCGCCGGCATTACCGGCGACTGGACCATGTCGGCCTATCGCGCCAAGGCGGTCG
AGGCGATCCGCAAGCAGGTCGGCGACAAGAAGGTGATCTGCGCGCTTTCCGGCGGCGTCGATTCATCCGTGGCAGCTCTC
CTCATCCACGAAGCGGTCGGGGATCAGCTTACCTGCATCCTCGTCGACCATGGTCTGATGCGCAAGGACGAGGCGGCGAA
CGTCGTCGCCATGTTCAAGGAGCACTACAACCTCCATCTGCTCCATATCGACGCTTCCGATCGCTTCATCGGCGAGCTCG
AAGGCGTCAGCGATCCGGAGACCAAGCGCAAGATCATCGGCCGTCTCTTCATCGAGGTCTTCGAGGAAGAGGCCAAGAAG
CTCGGCGGCGCCGATTTCCTCGCCCAGGGCACGCTCTATCCTGACGTCATCGAAAGCGTCTCCTTCACCGGCGGCCCCTC
GGTGACGATCAAGTCGCACCACAATGTCGGCGGCCTGCCGGAGCGCATGAACATGCAGCTCGTCGAGCCGCTGCGCGAGC
TCTTCAAGGACGAAGTCCGCGTGCTCGGCCGCGAACTCGGCCTGCCCGAAAGCTTCATCGGCCGCCATCCCTTCCCCGGC
CCCGGCCTCGCGATCCGCTGCCCCGGCGGCATCACGCGCGAGAAGCTGGAAATCCTGCGCGAAGCCGATGCGATCTATCT
CGACGAGATCCGCAAGGCCGGCCTCTACGACGCTATCTGGCAGGCCTTCGCCGTGCTGCTTCCCGTGCAGACGGTCGGCG
TCATGGGCGACGGGCGCACCTACGAATTCGTCTGCGCGCTGCGCGCCGTCACCTCCGTCGACGGCATGACCGCCGACTTC
TACCACTACGACATGGAATTCCTCGGCCGCGCCGCCACCCGCATCATCAACGAGGTCCGCGGCATCAACCGCGTCGTCTA
CGACGTCACGTCGAAGCCGCCGGGCACGATCGAGTGGGAGTGA

Protein sequence :
MTQTAHPDTVLIVDFGSQVTQLIARRVRESGVYCEIVPFQSAEEGFHRLKPKAVILSGSPASTLDTGSPRAPSVIFDSGL
PVFGICYGQQTMCAQLGGKVESGHHREFGRAFLEVEKDCPLFDGLWSLGSRHQVWMSHGDRVTALPEGFEVVATSSNAPF
AFIADEKRKYYAVQFHPEVVHTPDGAKLIANFVHKIAGITGDWTMSAYRAKAVEAIRKQVGDKKVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFKEHYNLHLLHIDASDRFIGELEGVSDPETKRKIIGRLFIEVFEEEAKK
LGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRVLGRELGLPESFIGRHPFPG
PGLAIRCPGGITREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-136 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-136 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-136 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-115 50