Gene Information

Name : MCA0278 (MCA0278)
Accession : YP_112812.1
Strain : Methylococcus capsulatus Bath
Genome accession: NC_002977
Putative virulence/resistance : Virulence
Product : type I restriction-modification system, M subunit
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : -
Position : 264441 - 266813 bp
Length : 2373 bp
Strand : -
Note : identified by similarity to OMNI:NTL03PA02735; match to protein family HMM PF02384; match to protein family HMM PF02506

DNA sequence :
ATGAAAAGTGGAAAAGTGCAAGACCAAAGCCAGATCAAGTGGATCTCCGACTTCATCTGGAACATCGCGGACAACCGCCT
GCGCGATGTCTATGTGCGCGGCAAATACCGCGATGTCATCCTGCCCTTCACCGTGCTGCGGCGGCTCGACGCGGTGTTGG
AAGAGACCAAGCAGAAGGTGTTGGAGCGCAAGCGCTTCCTCGACAAGAACAACGTCGCCGAGCAGGACGGGGCTCTGCGG
ATGGCCGCGGGGCAGGCGTTCTACAACGTCTCGGAATTCACCCTCGCCAAGCTCAAGGCCAGCAGTCAGGGCCAGCGTTT
GCGTGAGGATTTCATCGCCTACCTGGATGGCTTTTCACCGAACGTCCAGGAGATCCTCACCAAGTTCAAGTTTCGCGACC
AGATTCAGACGCTGGTAGATGCGCATGTTCTGGGCTACCTGATCGAGGACTTTCTCGACCCCGAGATCAATCTGTCGCCA
CTGCCGGTCAAAGACGCGGACGGCCGCATCAAGCTGCCCGCGCTGGACAACCACGGCATGGGCACTGTGTTTGAAGAACT
GATCCGCCGCTTCAACGAGGAAAACAACGAGGAGGCCGGTGAGCACTTCACGCCGCGGGATGTTGTCAGGCTCATGGCCA
AGCTGATGTTCATGCCAGTGGCCGACCAGATCCAGTCTGGCACCTACTTGCTCTACGACGGCGCCTGCGGCACCGGGGGC
ATGCTGACCGTCGCCGAGGAGACTCTGCGGGAGCTGGCCGAGGAACAAGGCAAGGAGGTCTCCATCCACCTGTTCGGGCA
GGAGATCAACCCCGAAACCTACGCTATCTGCAAGGCCGACCTGCTGCTCAAAGGCGAAGGCGATGAGGCCGAGCACATCG
TTGGTGGCGCGGACAAGTCCACCCTGTCCAACGACCAGTTCCGTTCCCGCGAGTTCGACTTCATGATCTCCAACCCGCCC
TACGGGAAGAGCTGGAAGACCGATCTCGACCGCATGGGCGGCAAGAAGGGGTTCAACGATCCGCGCTTCATCGTCAGCCA
CAGCGGCGACCCGGAGTTCAAGCTCATCACCCGCTCCAGCGACGGGCAGCTCATGTTCCTGGTGAACAAGCTGCAGAAGA
TGAAGCAGCACTCGCCCCTGGGCAGCCGCATCGCCATCGTCCACAACGGCTCCGCGCTGTTCACTGGCGATGCCGGCCAG
GGCGAGAGCAACATCCGGCGCTGGATACTGGAAAACGACTGGTGTGAGGCCATCATCGCCCTGCCGCTCAACATCTTCTA
CAACACGGGCATCGCGACTTACATCTGGGTGCTTACCAATCGCAAGGCTAAGCACCGTAAAGGCCGCGTGCAGCTCATCG
ACGCCACCCGTTGGTTCCAGCCGCTGCGCCGCAACCTCGGCAAGAAGAATTGCGAGCTGTCCGAGGCCGACATCCAGCGC
ATTCTCGACCTGTACCTCGGGCAACCGCAGAACACGCCCGAGTGCAAGTGGTTCGACAACGCCGACTTCGGCTACTGGAA
GATCACCGTCGAACGTCCGCTGCGGCTCAAAAGCCAGCTCACGCGCCGCGCCATCGAGACCTTGCGCTTTGCCAGCGGCG
ATGAAGCCCTGCGCGCCGAGATCTGGGCCAAGTACGGCGACAAGCTCTACGCAGAGTTTTCCAAGCTCAAGCCCGAGATC
GAGGCGTGGCTGAAGGGCGATACCGGGGAAGACGACGACGAGCCGGAGGGCGATGAAGACGAGGGCGCGCCCGCGAAGAA
GGCCGTGCCCGAGAAACGCCGCAAAAAGCTGCTCGATGTTTCGACCTGGCAACGCGACAAGACTTTAATCGAGCTGGCGC
TGCTCGCCCAACAGGAGCTTGGCGACGGCGTGTTCGACGACCACAACGACTTCCGCGCCCGTTTCGAGGCGGCCATGGCC
AAGCACGGAAAGAAACTGGCCGCCGCCGAAAAGAAGGCGATTTTCAAGGCCGTGAGCTGGCGTGACGAAACGGCGCCGCC
GGTGATTGCCAAGCGCACCAAGCTGAAAAAGGACGAACCGTTCGAGCCGGGGCTCGACGGCGTGTACCTCGAGGTGGCGG
GCAAAGACCGGTTCCTGGTCGAGTACGAGCCCGATGCCGACCTGCGCGATACCGAGCAGGTGCCGCTGAAGGAGCCCGGC
GGCATCGATGCCTTTTTCCGGCGCGAGGTGCTGCCTCACGCGCCGGATGCCTGGATCGCGCGGGACAAGACCCAGATCGG
CTACGAGATCTCCTTCGCCCGCTATTTCTACAAGCCTGCGCCGCTGCGCACGCTGGATGAGATTCGCGCCGACATCCTCC
GGCTGGAACAGCAGACCGAAGGCCTGTTGCAGAAGATCGTGGGGGGCGCGTGA

Protein sequence :
MKSGKVQDQSQIKWISDFIWNIADNRLRDVYVRGKYRDVILPFTVLRRLDAVLEETKQKVLERKRFLDKNNVAEQDGALR
MAAGQAFYNVSEFTLAKLKASSQGQRLREDFIAYLDGFSPNVQEILTKFKFRDQIQTLVDAHVLGYLIEDFLDPEINLSP
LPVKDADGRIKLPALDNHGMGTVFEELIRRFNEENNEEAGEHFTPRDVVRLMAKLMFMPVADQIQSGTYLLYDGACGTGG
MLTVAEETLRELAEEQGKEVSIHLFGQEINPETYAICKADLLLKGEGDEAEHIVGGADKSTLSNDQFRSREFDFMISNPP
YGKSWKTDLDRMGGKKGFNDPRFIVSHSGDPEFKLITRSSDGQLMFLVNKLQKMKQHSPLGSRIAIVHNGSALFTGDAGQ
GESNIRRWILENDWCEAIIALPLNIFYNTGIATYIWVLTNRKAKHRKGRVQLIDATRWFQPLRRNLGKKNCELSEADIQR
ILDLYLGQPQNTPECKWFDNADFGYWKITVERPLRLKSQLTRRAIETLRFASGDEALRAEIWAKYGDKLYAEFSKLKPEI
EAWLKGDTGEDDDEPEGDEDEGAPAKKAVPEKRRKKLLDVSTWQRDKTLIELALLAQQELGDGVFDDHNDFRARFEAAMA
KHGKKLAAAEKKAIFKAVSWRDETAPPVIAKRTKLKKDEPFEPGLDGVYLEVAGKDRFLVEYEPDADLRDTEQVPLKEPG
GIDAFFRREVLPHAPDAWIARDKTQIGYEISFARYFYKPAPLRTLDEIRADILRLEQQTEGLLQKIVGGA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC1769 NP_231404.1 DNA methylase HsdM Not tested VPI-2 Protein 8e-152 46
VC0395_A1367 YP_001217310.1 DNA methylase HsdM Not tested VPI-2 Protein 8e-152 46
VPI2_0017c ACA01834.1 DNA methylase HsdM Not tested VPI-2 Protein 7e-152 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MCA0278 YP_112812.1 type I restriction-modification system, M subunit VFG1102 Protein 3e-152 46