Gene Information

Name : thyA (MCA2728)
Accession : YP_115128.1
Strain : Methylococcus capsulatus Bath
Genome accession: NC_002977
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2921815 - 2922597 bp
Length : 783 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCGCCCTTATCTCGACCTGCTGCGCGACATCCTCGATCACGGCTGCCCCAAAGGGGACCGGACCGGCACCGGGACCCT
GAGCGTGTTCGGCCGCATGATGCGGTTCGACCTGTCGCGGGGGCTTCCCCTCGTCACCACCAAGAAACTGCATCTGCCCT
CGATCATCCATGAACTGCTCTGGTTCGTCTCCGGCAGCACCAACGTGCGTGATCTGCAACGGCACGGCGTCACGATCTGG
GACGAGTGGGCGGATGACAATGGTGAGTTAGGCCCCGTGTATGGACGCCAATGGCGGAATTGGAACGGCGCCATCGATCA
GCTTGCCGGACTGGTCGAGCAACTGCGCCGGAATCCGGGCTCCCGCCGCCTGCTGGTGAGCGCATGGAACCCCTCCGATC
TGGATGCCATGGCGCTGCCGCCCTGCCACTACGCCTTTCAGTGCCATGTGGCGGATGGAAGGCTGTCGCTCATGTTCCAG
ATGCGTTCGGCGGACGTGTTCCTGGGACTGCCGTTCAATATCGCCGGCTATGCCCTGCTCACCCATATGCTTGCGCAACA
GACCGGATACGAACCGGGGGAGTTGATATGGTGCGGCGGTGACGTGCATCTGTACCTCAACCACCTGGAGCAGGCGCGCC
TGCAACTCACGCGCGAACCCTATCCGCCGCCCACGCTGAAACTCGCCCGCAAGCCCGGGAGCCTGTTCGATTACCGCTAC
GAGGATTTCGTGGTCGAGGACTACCAGGCGCATCCACACATCAAAGCGGCGGTGGCGGTGTGA

Protein sequence :
MRPYLDLLRDILDHGCPKGDRTGTGTLSVFGRMMRFDLSRGLPLVTTKKLHLPSIIHELLWFVSGSTNVRDLQRHGVTIW
DEWADDNGELGPVYGRQWRNWNGAIDQLAGLVEQLRRNPGSRRLLVSAWNPSDLDAMALPPCHYAFQCHVADGRLSLMFQ
MRSADVFLGLPFNIAGYALLTHMLAQQTGYEPGELIWCGGDVHLYLNHLEQARLQLTREPYPPPTLKLARKPGSLFDYRY
EDFVVEDYQAHPHIKAAVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 3e-67 59