Gene Information

Name : ureC (SERP1871)
Accession : YP_189432.1
Strain : Staphylococcus epidermidis RP62A
Genome accession: NC_002976
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1895580 - 1897295 bp
Length : 1716 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAGTTTTAAAATGACACAATCTCAATACACAAGTCTTTATGGACCAACTGTAGGAGACTCTGTGAGATTAGGAGATAC
GAACTTGTTTGCACAAGTTGAAAAAGACTATGCAAATTATGGAGATGAAGCTACTTTCGGTGGCGGAAAATCAATTCGTG
ATGGTATGGCTCAAAATCCTAATGTGACAAGAGATGATAAAAATGTAGCCGATTTAGTTTTAACTAACGCATTAATTATT
GATTATGACAAGATTGTTAAAGCAGATATCGGAATTAAAAATGGTTATATTTTTAAGATCGGTAAAGCTGGAAACCCAGA
TATAATGGATAACGTTGACATCATCATTGGTGCAACAACTGATATTATTGCTGCTGAAGGTAAAATTGTTACTGCCGGCG
GTATCGATACACACGTGCACTTCATCAATCCTGAACAAGCTGAAGTTGCACTTGAGAGTGGTATTACAACGCATATCGGT
GGAGGAACTGGTGCTTCTGAAGGTGCTAAAGCGACTACTGTAACACCAGGACCTTGGCATATTCATCGCATGTTAGAAGC
AGCAGAAGAGATGCCTATTAATGTAGGATTTACTGGTAAAGGTCAAGCTGTCAATCATACTGCACTTATTGAACAAATTC
ATGCAGGCGCTATAGGTCTTAAAGTACATGAAGATTGGGGAGCTACACCTTCAGCATTAAGTCATGCATTAGACGTTGCA
GATGAGTTTGATGTTCAAGTCGCTTTACATGCAGATACATTAAATGAAGCTGGATTTATGGAAGATACAATGGCTGCTGT
GAAAGATCGTGTATTGCATATGTATCATACTGAAGGAGCTGGTGGTGGTCATGCACCTGACTTAATCAAATCAGCTGCAT
ATTCAAACATCTTACCTTCTTCTACAAACCCAACATTACCTTACACTCACAACACTGTAGATGAACATTTAGACATGGTT
ATGATTACTCACCATCTTAATGCTTCAATACCAGAAGACATTGCATTTGCAGATTCTCGTATACGTAAGGAAACTATAGC
AGCAGAAGACGTATTACAAGATATGGGCGTATTTAGTATGGTAAGTTCAGATTCACAAGCAATGGGACGTGTCGGTGAAG
TTGTAACACGTACTTGGCAAGTTGCACACCGTATGAAAGAACAACGCGGACCATTAGATGGTGACTTTGAATATCACGAT
AATAATCGTATTAAACGTTACATTGCAAAATATACAATCAATCCTGCCATTACACATGGTATTTCTGACTATGTTGGATC
TGTAGAAGCGGGTAAACTTGCCGATTTAGTAATGTGGGAACCAGAATTCTTCGGTGCCAAACCCGATCTTGTTGTTAAAG
GTGGCATGATTAACTCAGCAGTAAATGGTGATGCTAATGGCTCCATACCAACATCAGAGCCTTTGAAATATCGCAAAATG
TATGGTCAATTTGGTGGTAACATTACACATACTGCTATGACTTTTGTTTCTAACACTGCATATGAAAACGGTATTTATCG
TCAACTCAATCTAAAACGAATGGTTCGACCAGTTAGAAATATTAGAAATTTAACTAAGGCAGATATGAAAAATAATAATG
CTACACCTAAAATAGATGTAGATCCACAAACATATGAGGTATTCGTTGATGGTAATAAAATCACAAGTGAAGCAGCAACA
GAATTACCATTAACACAAAGATACTTCTTATTCTAG

Protein sequence :
MSFKMTQSQYTSLYGPTVGDSVRLGDTNLFAQVEKDYANYGDEATFGGGKSIRDGMAQNPNVTRDDKNVADLVLTNALII
DYDKIVKADIGIKNGYIFKIGKAGNPDIMDNVDIIIGATTDIIAAEGKIVTAGGIDTHVHFINPEQAEVALESGITTHIG
GGTGASEGAKATTVTPGPWHIHRMLEAAEEMPINVGFTGKGQAVNHTALIEQIHAGAIGLKVHEDWGATPSALSHALDVA
DEFDVQVALHADTLNEAGFMEDTMAAVKDRVLHMYHTEGAGGGHAPDLIKSAAYSNILPSSTNPTLPYTHNTVDEHLDMV
MITHHLNASIPEDIAFADSRIRKETIAAEDVLQDMGVFSMVSSDSQAMGRVGEVVTRTWQVAHRMKEQRGPLDGDFEYHD
NNRIKRYIAKYTINPAITHGISDYVGSVEAGKLADLVMWEPEFFGAKPDLVVKGGMINSAVNGDANGSIPTSEPLKYRKM
YGQFGGNITHTAMTFVSNTAYENGIYRQLNLKRMVRPVRNIRNLTKADMKNNNATPKIDVDPQTYEVFVDGNKITSEAAT
ELPLTQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-171 64
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 7e-173 64
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 7e-173 64
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 7e-173 64
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 9e-169 63
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 9e-169 63

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_189432.1 urease subunit alpha VFG0270 Protein 1e-152 59