Gene Information

Name : pyk (SERP1261)
Accession : YP_188834.1
Strain : Staphylococcus epidermidis RP62A
Genome accession: NC_002976
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1302046 - 1303803 bp
Length : 1758 bp
Strand : -
Note : identified by similarity to EGAD:37614; match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064

DNA sequence :
ATGAGAAAGACTAAAATTGTATGTACAATAGGACCAGCTTCAGAATCAGAGGAAATGCTCGAAAAACTAATGAATGCAGG
AATGAACGTTGCGCGTTTAAATTTCTCACATGGTAGTCATGAAGAACATAAAGCAAGAATTGATACAATTCGTAAAGTTG
CTAAACGTTTAAATAAAACAATTGGCTTGTTATTGGATACTAAAGGGCCAGAAATTCGTACGCACAATATGAAAGATGGA
CTTATTGTTTTAGAAAAAGGCAAAGAAGTCATTGTCAGTATGAATGAAGTTGAAGGAACACCTGAAAAATTCTCTGTAAC
ATATGAAAATCTAATCAATGATGTCAATATTGGATCATATATACTATTAGATGATGGTTTAGTTGAACTTCAAGTCAAAG
AAATTAACAAAGATAAAGGCGAAGTTAAATGTGATATCTTAAATACTGGTGAATTAAAAAATAAAAAAGGTGTTAACTTA
CCTGGTGTTAAAGTTAATTTACCTGGTATCACTGATAAAGATGCCGATGATATCAGATTTGGTATAAAGGAAAATGTAGA
CTTTATAGCTGCAAGTTTTGTAAGACGTCCAAGTGATGTTTTAGATATCCGTCAAATTCTTGAAGAAGAAAAAGCAGAAA
TAACAATTTTCCCTAAAATCGAAAACCAAGAAGGTATCGATAATATTGAAGAAATTCTTGAAGTATCTGATGGATTAATG
GTAGCACGTGGTGATATGGGTGTTGAAATTCCACCAGAAAGCGTACCAATGGTTCAAAAAGATTTAATTAGAAAATGTAA
TAAATTAGGAAAACCTGTAATTACTGCGACTCAAATGCTTGATTCTATGCAACGTAATCCACGTGCGACACGTGCAGAAG
CAAGTGACGTAGCTAATGCAATATACGATGGTACTGACGCGGTAATGTTATCAGGTGAAACTGCAGCAGGTCAATATCCT
GAAGAAGCTGTTAAAACTATGCGTAATATTGCAGTTTCTGCTGAAGCAGCGCAAGACTATAAAAAATTATTAAGTGATCG
TACTAAATTAGTTGAAACTTCATTAGTAAATGCAATTGGTGTTTCTGTTGCACATACTGCCTTAAACTTAAATGTAAAAG
CTATTGTAGCAGCAACTGAAAGTGGTTCAACAGCACGTACGATTTCTAAATATCGTCCACATTCAGATATCATTGCTGTA
ACACCTAGCGAAAAAACTGCTAGACAATGTGCAATTGTATGGGGAGTAAATCCGGTCGTTAAAGAAGGACGTAAAACAAC
TGATGCTTTACTAAATAATGCTGTAGCAACAGCAGTAGAAACTGGTAGAGTTTCAAACGGAGATTTAATTATTATTACTG
CTGGTGTACCTACTGGAGAAAAAGGAACTACAAATATGATGAAAATCCACTTAGTAGGTGATGAGATTGCTAAAGGTCAA
GGTGTTGGTAGAGGATCTGTTGTAGGCCATGCAATTGTCGCAGATAGTGCTAGTGATTTAGAAGGTAAAGATTTATCTGA
TAAAGTTATTATTACAAATTCTGTTGATGAAACATTAGTACCATATGTTGAAAAAGCTATAGGTCTAATTACAGAAGAAA
ATGGTATTACTTCACCAAGCGCAATTATAGGTTTAGAAAAAGGCATACCTACTGTTGTTGGTGTAGAACAAGCAACCAAA
GAAATTAAAAATGATATGTTAGTGACTTTAGATGCGTCACAAGGTAAAGTGTTTGAAGGTTATGCTAACGTCCTTTAA

Protein sequence :
MRKTKIVCTIGPASESEEMLEKLMNAGMNVARLNFSHGSHEEHKARIDTIRKVAKRLNKTIGLLLDTKGPEIRTHNMKDG
LIVLEKGKEVIVSMNEVEGTPEKFSVTYENLINDVNIGSYILLDDGLVELQVKEINKDKGEVKCDILNTGELKNKKGVNL
PGVKVNLPGITDKDADDIRFGIKENVDFIAASFVRRPSDVLDIRQILEEEKAEITIFPKIENQEGIDNIEEILEVSDGLM
VARGDMGVEIPPESVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGQYP
EEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGVSVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAV
TPSEKTARQCAIVWGVNPVVKEGRKTTDALLNNAVATAVETGRVSNGDLIIITAGVPTGEKGTTNMMKIHLVGDEIAKGQ
GVGRGSVVGHAIVADSASDLEGKDLSDKVIITNSVDETLVPYVEKAIGLITEENGITSPSAIIGLEKGIPTVVGVEQATK
EIKNDMLVTLDASQGKVFEGYANVL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 6e-94 48
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 4e-94 48
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 4e-94 48
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 1e-93 48
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 5e-57 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_188834.1 pyruvate kinase VFG0479 Protein 2e-94 48