Gene Information

Name : hly (LMOf2365_0213)
Accession : YP_012823.1
Strain : Listeria monocytogenes F2365
Genome accession: NC_002973
Putative virulence/resistance : Virulence
Product : listeriolysin O
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 211179 - 212768 bp
Length : 1590 bp
Strand : +
Note : identified by similarity to SP:P13128; match to protein family HMM PF01289

DNA sequence :
ATGAAAAAAATAATGCTAGTTTTTATTACACTTATATTAGTTAGTCTACCAATTGCGCAACAAACTGAAGCAAAGGATGC
ATCTGCATTCAATAAAGAAAATTTAATTTCATCCATAGCACCACCAGCATCTCCGCCTGCAAGTCCTAAGACGCCAATCG
AAAAGAAACACGCGGATGAAATCGATAAGTATATACAAGGATTGGATTACAATAAAAACAATGTATTAGTATACCACGGA
GATGCAGTGACAAATGTGCCGCCAAGAAAAGGTTATAAAGATGGAAATGAATATATCGTTGTGGAGAAAAAGAAGAAATC
CATCAATCAAAATAATGCAGATATCCAAGTTGTGAATGCAATTTCGAGCCTAACATATCCAGGTGCTCTCGTGAAAGCGA
ATTCGGAATTAGTAGAAAATCAACCCGATGTTCTTCCTGTCAAACGTGATTCATTAACACTTAGCATTGATTTGCCAGGA
ATGACTAATCAAGACAATAAAATTGTTGTAAAAAATGCTACTAAATCGAACGTTAACAACGCAGTAAATACATTAGTGGA
AAGATGGAATGAAAAATATGCTCAAGCTTATCCAAATGTAAGTGCAAAAATTGATTATGATGACGAAATGGCTTACAGTG
AATCACAATTAATTGCAAAATTTGGTACGGCATTTAAAGCTGTAAATAATAGCTTGAATGTAAACTTCGGCGCAATCAGT
GAAGGGAAAATGCAAGAAGAAGTCATTAGTTTTAAACAAATTTACTATAACGTGAATGTTAATGAACCTACAAGACCTTC
CAGATTTTTCGGCAAAGCTGTTACTAAAGAGCAGTTGCAAGCGCTTGGAGTGAATGCAGAAAATCCTCCTGCATATATCT
CAAGTGTGGCATATGGCCGTCAAGTTTATTTGAAATTATCAACTAATTCCCATAGTACCAAAGTAAAAGCTGCTTTTGAC
GCTGCCGTAAGTGGGAAATCTGTCTCAGGTGATGTAGAACTGACAAATATCATCAAAAATTCTTCCTTCAAAGCCGTAAT
TTACGGTGGCTCCGCAAAAGATGAAGTTCAAATCATCGACGGTAACCTCGGAGACTTACGAGATATTTTGAAAAAAGGTG
CTACTTTTAACCGGGAAACACCAGGAGTTCCCATTGCCTATACAACAAACTTCTTAAAAGACAATGAATTAGCTGTTATT
AAAAACAACTCAGAATATATTGAAACAACTTCAAAAGCTTATACAGATGGAAAAATCAACATCGATCACTCTGGAGGATA
CGTTGCTCAATTCAACATCTCTTGGGATGAAATAAATTATGATCCTGAAGGTAACGAAATTGTTCAACATAAAAACTGGA
GCGAAAACAATAAAAGTAAGCTAGCTCATTTCACATCGTCCATCTATTTGCCAGGTAACGCAAGAAATATTAATGTTTAC
GCTAAAGAATGCACTGGTTTAGCTTGGGAATGGTGGAGAACGGTAATTGATGACCGGAACCTACCGCTTGTGAAAAATAG
AAATATCTCCATCTGGGGCACTACACTTTATCCGAAATATAGTAATAGTGTAGATAATCCAATCGAATAA

Protein sequence :
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENLISSIAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHG
DAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPG
MTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAIS
EGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFD
AAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVI
KNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEINYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVY
AKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNSVDNPIE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hly AAA69525.1 listeriolysin O Virulence LIPI-1 Protein 0.0 100
slo YP_281505.1 streptolysin O Virulence Not named Protein 9e-99 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hly YP_012823.1 listeriolysin O VFG0074 Protein 0.0 99
hly YP_012823.1 listeriolysin O VFG1363 Protein 4e-107 44
hly YP_012823.1 listeriolysin O VFG2275 Protein 3e-104 44
hly YP_012823.1 listeriolysin O VFG0976 Protein 3e-99 43