Gene Information

Name : thiC (CBU_0330)
Accession : NP_819372.2
Strain : Coxiella burnetii RSA 493
Genome accession: NC_002971
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 296556 - 298220 bp
Length : 1665 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
TTGCGAAGGGAAGGGACGATGCGGCTGCATCGCACTTTCCTTCTGCGTGTTTATTTGAAGGAGAGTGCTGTGATTACTTA
TCCTGCTTCCAAAAAGATTTATTGCCAAGGCAAGATTTTCCCCACTATTCGCGTAGGAATGCGTGAAATTCAATTGACGA
ACGGTGATTCGCTAACCCTTTACGATACCTCAGGTCCGTATTCTGACCCGAATATCTCTATCAAATCGCCGCAGGGACTT
CCCCGCTTGCGCGAGCCTTGGATTAAAGTGCGCCCGAGGAAAACGCAATTGGCTTTCGCAAAAGAAGGCGTCATTACACC
AGAAATGGAATACGCTGCGATTCGTGAAAATCAAAAAAGAGAGTTGAAGAAAAACACGGATCAAGAACGCGAACGTCGTT
TGCAAGGAAATTCGTTGAGTGCGCGAATTCCTAACCCAATTACGCCGGAATTTATTCGAAATGAAATCGCGTGCGGTCGT
GCCATCTTGCCTGCGAATATTAATCATCCCGAAAGCGAGCCTATGATTATTGGTCGCCATTTTTTAGTTAAAGTAAACGC
GAATATTGGGAACTCGTCGCTTACGTCATCTGTGGAGGAAGAAGTTGAAAAATTAATTTGGGCATTGCGTTGGGGGGCGG
ATACGGTGATGGATCTATCGACGGGAAAAAAAATCAAAGAAATTCGTGAAACAATTCTTCGTCATTCTCCGGTACCTATC
GGTACCGTGCCGTTGTATGAAGCATTGGAAAAAGTGGATGGAGATGTAAAAGCCCTAACCTGGGAAATTTTCCGCGACAC
CTTAATTTCGCAAGCTGAACAAGGAGTTGATTATTTCACGATTCATGCAGGTGTTTTAAATCGTTTTATTCCATTGACCC
AAAAACGCGTCACGGGAATTGTTTCTCGCGGTGGCTCTCTCATGGCCAAATGGTGTCTTTTGCACCGAGAGGAGAATTTT
CTTTATACGCATTTTACTGAGATTTGTGAAATTATGCGCGCTTATGATGTGAGCTTTTCGCTAGGGGATGGGTTGCGCCC
AGGCTCTATTGCTGATGCCAATGATGAAGCGCAATTTGCAGAATTGAAAATTCAAGGCGAATTAAATCGCATTGCGTGGA
AATACGGTGTGCAGGTGATGAATGAAGGACCAGGGCATATCCCTCTAAACCTCATCGAAGAAAATATGACGAAACAGTTG
GCTTATTGCCGGGAAGCGCCATTTTATACCCTGGGACCATTAACTACCGATATTGCGCCTGGTTATGATCATATCGGTAG
CGCTATTGGCGCTGCTTTTATCGCTTGGCAAGGGTGCGCGCTCTTGTGCTATGTCACGCCGAAAGAACATTTGGGATTAC
CGAACAAACAAGACGTCAAAGAAGGACTGATTGCTTATAAAATTGCGGCCCATGCCGCAGATTTAGCAAAAGGACACCCA
GCGGCTCGACAGCGAGATTATTTATTATCGCAAGCGCGGTTTGAATTCCGCTGGCACGATCAATTTAATTTAGCGTTAGA
CGCTGAAACAGCGCGCCTTTTTCATGATGAGACTTTGCCAAAAGAGGCTGCTAAACACGCTCATTTTTGTTCATTGTGCG
GCCCTAAATTTTGCGCTTACAAAACGAGCCACGAGGTTAGGGATACCTTACAAAAGGTAACGTAA

Protein sequence :
MRREGTMRLHRTFLLRVYLKESAVITYPASKKIYCQGKIFPTIRVGMREIQLTNGDSLTLYDTSGPYSDPNISIKSPQGL
PRLREPWIKVRPRKTQLAFAKEGVITPEMEYAAIRENQKRELKKNTDQERERRLQGNSLSARIPNPITPEFIRNEIACGR
AILPANINHPESEPMIIGRHFLVKVNANIGNSSLTSSVEEEVEKLIWALRWGADTVMDLSTGKKIKEIRETILRHSPVPI
GTVPLYEALEKVDGDVKALTWEIFRDTLISQAEQGVDYFTIHAGVLNRFIPLTQKRVTGIVSRGGSLMAKWCLLHREENF
LYTHFTEICEIMRAYDVSFSLGDGLRPGSIADANDEAQFAELKIQGELNRIAWKYGVQVMNEGPGHIPLNLIEENMTKQL
AYCREAPFYTLGPLTTDIAPGYDHIGSAIGAAFIAWQGCALLCYVTPKEHLGLPNKQDVKEGLIAYKIAAHAADLAKGHP
AARQRDYLLSQARFEFRWHDQFNLALDAETARLFHDETLPKEAAKHAHFCSLCGPKFCAYKTSHEVRDTLQKVT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 3e-167 64
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 3e-167 64
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 4e-156 60