Gene Information

Name : metC (CBU_2025)
Accession : NP_820998.1
Strain : Coxiella burnetii RSA 493
Genome accession: NC_002971
Putative virulence/resistance : Resistance
Product : O-succinylhomoserine (thiol)-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 1932869 - 1934032 bp
Length : 1164 bp
Strand : +
Note : -

DNA sequence :
GTGACAGCTAACAACAATAAAAAATCACACATCGATACACGTGTCATTCACGCCGGACAAAAACCGGACCCCTTAACCGG
CGCCGTCATGACGCCCATCTATACCGCTTCCACTTATGCGCAAAAAAGTCCAGGCGTTCATCAAGGGTACGAATATTCTC
GCAGCCAAAATCCGACGCGCTTTGCTTATGAACGTTGTGTTGCGGATTTAGAGTCTGGACAACACGGTTTTGCTTTTGCG
TCAGGAATGGCCGCCACCGCCACTATTTTAGAACTCTTGCAACCGGGCGATCATGTAGTGGTGATGGACGACGTTTATGG
GGGCTCCTATCGTTTATTTGAAAATGTACGAAAGCGATCAGCCGGCCTTTCTTTTTCGTTCGTCGATTTCACGGACGAAA
ATAAAGTGCGAGAAGCCGTCACCGCAAAAACTAAAATGTTGTGGGTAGAATCACCAAGCAATCCTCGGCTTAAAATCGTT
GATCTTGCAAAAATTGCGGAAATCGCAAAAGAAAAAAATATCATCGCGGTTGCCGACAACACCTTCGCCACACCGATTAT
TCAACGCCCATTAGAATTAGGCTTCGATATCGTTACACATTCGGCAACAAAATATTTAAATGGCCATTCTGATATCATCG
GCGGCGTAGCCGTGGTGGGCGACAATAAAACTTTAGCCGAACAATTAAAATATTTACAAAACGCCATAGGCGCTATCGCC
GCGCCTTTCGATAGTTTTATGGTTTTACGCGGATTAAAAACGTTAGCCATTCGAATGGAACGCCATTGTGAAAATGCGAT
GCAGTTAGCCCAATGGCTAGAAAAACACCCCAAAGTAAAACGCGTTTATTACCCTGGCTTACCAAGCCACCCCCAGCACT
CGATTGCTAAAAAACAAATGCGTTATTTTGGCGGCATGATTTCTGTCGAACTAAAATGCGATTTAAATGAGACTAAAAAA
GTACTCGAACGCTGCCAACTGTTCACCTTAGCGGAAAGCCTCGGCGGTGTTGAAAGCCTCATCGAACACCCCGCCATAAT
GACCCACGCCTCCATTCCACAAGCAGAACGCCAAAAACTGGGCATAACGGATGGTTTTATCCGCCTCTCCGTTGGCATCG
AAGCGATAACTGATTTGCGCCACGATCTAGAAGCAGCGCTTTAA

Protein sequence :
MTANNNKKSHIDTRVIHAGQKPDPLTGAVMTPIYTASTYAQKSPGVHQGYEYSRSQNPTRFAYERCVADLESGQHGFAFA
SGMAATATILELLQPGDHVVVMDDVYGGSYRLFENVRKRSAGLSFSFVDFTDENKVREAVTAKTKMLWVESPSNPRLKIV
DLAKIAEIAKEKNIIAVADNTFATPIIQRPLELGFDIVTHSATKYLNGHSDIIGGVAVVGDNKTLAEQLKYLQNAIGAIA
APFDSFMVLRGLKTLAIRMERHCENAMQLAQWLEKHPKVKRVYYPGLPSHPQHSIAKKQMRYFGGMISVELKCDLNETKK
VLERCQLFTLAESLGGVESLIEHPAIMTHASIPQAERQKLGITDGFIRLSVGIEAITDLRHDLEAAL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-77 49
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 7e-78 49
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-55 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metC NP_820998.1 O-succinylhomoserine (thiol)-lyase BAC0207 Protein 6e-61 41