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Name : guaA (CBU_1341) Accession : NP_820330.1 Strain : Coxiella burnetii RSA 493 Genome accession: NC_002971 Putative virulence/resistance : Unknown Product : GMP synthase Function : - COG functional category : F : Nucleotide transport and metabolism COG ID : COG0519 EC number : 6.3.5.2 Position : 1288616 - 1290190 bp Length : 1575 bp Strand : - Note : glutamine-hydrolyzing; contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway DNA sequence : ATGCTAAAAGATATCCATCAACATCGCATTTTAATTCTTGATTTCGGTTCGCAATACGCTCAATTAATCGCGCGGCGAGT GCGGGAAATTGGCGTTTATTGTGAATTAATGCCCTGTGATATCGATGAGGAAACTATTCGCGACTTTAATCCACACGGCA TTATTCTTTCAGGTGGGCCGGAGACCGTCACGTTAAGTCATACGCTTCGCGCACCCGCTTTTATTTTTGAAATTGGTTGC CCGGTGCTGGGTATTTGTTATGGTATGCAAACGATGGCATATCAGCTCGGCGGAAAAGTTAATAGGACGGCTAAAGCTGA ATTTGGACATGCGCAATTGCGGGTATTAAATCCCGCTTTTTTATTTGACGGTATTGAAGATCAAGTTTCGCCTCAAGGCG AACCTTTGTTAGACGTTTGGATGAGCCATGGTGATATTGTTAGCGAATTACCGCCAGGCTTTGAAGCCACAGCTTGCACC GACAATTCGCCTCTAGCGGCGATGGCGGATTTCAAACGGCGATTTTTCGGTTTGCAATTTCATCCTGAAGTCACGCACAC CCCTCAAGGGCATCGTATTTTAGCGCATTTTGTAATTCACATTTGTCAATGCATACCCAATTGGACTACTAAACATATTA TCGAAGACAGCATTCGAGATATTCAGGAAAAAGTCGGCAAAGAACAGGTTATTGTGGGATTATCCGGGGGCGTGGATTCC GCGGTGACAGCGACGCTGGTTCATAAAGCCATCGGCGATCAATTAGTTTGTGTTTTAGTCGACACCGGATTGTTGCGGTT GAATGAAGTGGATGAAGTTTTGAATGTATTTCAAAAACATTTAGGAGCCAAGGTTATTTGCGTTGATGCAAAAGATCGTT TTATGAAAGCGTTGAAAGGAATTTCAGACCCTGAGGAGAAGCGCAAAATTGCCGGCGAACAATTTATTCGTGTATTTGAG GAACAAGCTAAAAAATTAAATGTAAAATGGCTGGGGCAAGGGACTATTTATCCCGACGTTATTGAATCTGCAAAAACAAA AACGGGAAAAGGCCATATTATTAAAACGCACCATAATGTGGGTGGACTGCCGTTAAATATGGAATTGAAACTCATCGAGC CGCTACGGGAATTGTTTAAAGATGAAGTGCGCAAATTAGGACTTGAATTAGGATTGCCCGCAGATTTAATTTACCGACAT CCGTTTCCCGGTCCCGGACTCGCGATCCGCATTTTGGGAGAAGTAAGTGCAGAATATATTAATATTTTGAAACAGGCTGA TGCCATTTTTATTGAAGAATTAAAAAAATCCGATTACTACCACCAAGTCAGTCAAGCCTTTGCTGTTTTTATGCCTTTGA AATCCGTGGGCGTTAAAGGAGATGCGCGGCATTATGGCTATATTATCGCTTTGCGCGCTGTAAAAACGGTGGATTTTATG ACAGCACAATGGGCGGATTTGCCGCATGAATTTTTATCTAAGGTAAGTCATCGAATAGTGAATGAAATTAAAGAAGTCTC CCGCGTTGTTTATGACATGACTAATAAACCGCCGGCGACGATTGAATGGGAGTAA Protein sequence : MLKDIHQHRILILDFGSQYAQLIARRVREIGVYCELMPCDIDEETIRDFNPHGIILSGGPETVTLSHTLRAPAFIFEIGC PVLGICYGMQTMAYQLGGKVNRTAKAEFGHAQLRVLNPAFLFDGIEDQVSPQGEPLLDVWMSHGDIVSELPPGFEATACT DNSPLAAMADFKRRFFGLQFHPEVTHTPQGHRILAHFVIHICQCIPNWTTKHIIEDSIRDIQEKVGKEQVIVGLSGGVDS AVTATLVHKAIGDQLVCVLVDTGLLRLNEVDEVLNVFQKHLGAKVICVDAKDRFMKALKGISDPEEKRKIAGEQFIRVFE EQAKKLNVKWLGQGTIYPDVIESAKTKTGKGHIIKTHHNVGGLPLNMELKLIEPLRELFKDEVRKLGLELGLPADLIYRH PFPGPGLAIRILGEVSAEYINILKQADAIFIEELKKSDYYHQVSQAFAVFMPLKSVGVKGDARHYGYIIALRAVKTVDFM TAQWADLPHEFLSKVSHRIVNEIKEVSRVVYDMTNKPPATIEWE |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| SAMSHR1132_03620 | YP_005324884.1 | GMP synthase | Not tested | vSa¥á | Protein | 2e-119 | 50 |
| SAPIG0468 | YP_005733278.1 | GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) | Not tested | SAPI-S0385 | Protein | 2e-119 | 50 |
| guaA | YP_001331415.1 | GMP synthase | Not tested | vSa¥á | Protein | 2e-119 | 50 |
| guaA | NP_938969.1 | GMP synthase | Not tested | Not named | Protein | 2e-106 | 46 |
