Gene Information

Name : fliI (TDE1218)
Accession : NP_971825.1
Strain : Treponema denticola ATCC 35405
Genome accession: NC_002967
Putative virulence/resistance : Virulence
Product : flagellum-specific ATP synthase FliI
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.14
Position : 1250587 - 1252011 bp
Length : 1425 bp
Strand : +
Note : identified by similarity to SP:P23445; match to protein family HMM PF00006; match to protein family HMM PF02874; match to protein family HMM TIGR01026

DNA sequence :
ATGGTAGATCTGTTTGATAAATATACCAATGCTGTCTCAGAAACCGATCCGATAAAATTTACCGGACGTGTAGTCCGTGT
TCATGATAAATTAATTGAAAGTGAAGGTCCTGTGGCTTCCGTAGGAGAACTTTGCCAGATTATTACGGATGATAATCCTG
ATGGATTAAAGGCTGAGGTTGTAGGCTTAAACGGAACTATCGTTCAGCTTATGAGTTATACCGATGTGCAAGGTGTAAAA
ATAGGTGACCTTGTTATTGCAAGCGGAGAAATTCTATCCGTCCCGGTTGGAAATATTTTACTGGGCCGTGTTGTAGATGC
TTTATGTAAATCTGCTGACGGTAAACCTGAGCCTTATTCGGCAAAAAGATATCCTGTTGTAGCTTCTCCCCCGGATGCTA
TGACCCGAAAGCCCATAAGACAAAGAATAGTTACCGGTATCCGTGCTATCGATAGTCTTTTGGCAGTGGGGCGCGGACAG
CGTCTTGGTATTTTTGCAGGTACCGGTATCGGAAAATCTACCTTGCTTGGAATGATAGCTCGAAACACAAATGCCGACGT
AAATGTTATAGCTCTTATAGGAGAGCGCGGACGTGAAGTTTTGGATTTTATTGAGCATGATCTGGGACCTGAAGGTTTAA
AACATTCGGTAATTGTAAGTGCAACCTCCGATCAAAGTGCTCTTGCAAGAATAAGAGGAGCATACACCGCTACGGCCATT
GCAGAATACTTTAGAGATCAAGGAAAAGATGTTATGCTTCTTTTTGATTCCGTAACACGCTTTGCTATGGCACAAAGAGA
GATAGGACTTGCCATAGGAGAGCCTCCTGCAACTCGCGGATATACTCCCAGTGTTTTTAGTTCGCTTCCTAAACTGCTTG
AAAGAAGCGGTACCTCCGAAAAAGGTTCCATTACAGGATTTTATACCGTATTAGTTGAAGGTGACGATATGAACGAGCCG
ATTTCGGATGCCGTACGAGGTATTTTAGATGGTCATATTGTATTGGATAGAAATCTTGCCGAAAGAGGACAATATCCTGC
CGTTAATGTTTTAAAAAGTATTTCCAGATTATCCAACAGAGTATCGGGACCAAACACAAAGGATGCATCAAAACGAATGC
GCACATTATTAAAAGACTATACCGAATCCGAAGATATGATAAATCTCGGTGCTTATCAAAAAGGAAGCAGTGCAGCAATC
GATGATGCTATCGATCACTATCCGCGTATTTATGATTTTTTAACACAAGAGGTGGATGATCCTGCAAAACTAAAAGACAC
TTTACAAAAACTTTCGGATATTACGGGTATAGATATTCCTCCCGAAGAATTTGATGAAGCAGGTTTGGGTGTTGGGGCTA
TAAAAAAATATGCTCAAAGTTCTGAGGCCTCCGCATTATATAAACCGGATCGAGAGGTTAATTAA

Protein sequence :
MVDLFDKYTNAVSETDPIKFTGRVVRVHDKLIESEGPVASVGELCQIITDDNPDGLKAEVVGLNGTIVQLMSYTDVQGVK
IGDLVIASGEILSVPVGNILLGRVVDALCKSADGKPEPYSAKRYPVVASPPDAMTRKPIRQRIVTGIRAIDSLLAVGRGQ
RLGIFAGTGIGKSTLLGMIARNTNADVNVIALIGERGREVLDFIEHDLGPEGLKHSVIVSATSDQSALARIRGAYTATAI
AEYFRDQGKDVMLLFDSVTRFAMAQREIGLAIGEPPATRGYTPSVFSSLPKLLERSGTSEKGSITGFYTVLVEGDDMNEP
ISDAVRGILDGHIVLDRNLAERGQYPAVNVLKSISRLSNRVSGPNTKDASKRMRTLLKDYTESEDMINLGAYQKGSSAAI
DDAIDHYPRIYDFLTQEVDDPAKLKDTLQKLSDITGIDIPPEEFDEAGLGVGAIKKYAQSSEASALYKPDREVN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 9e-89 50
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 2e-89 50
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 9e-89 50
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 3e-89 50
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-89 50
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-99 49
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-97 49
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-98 49
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 7e-97 49
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 5e-98 49
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 2e-98 49
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 2e-98 49
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 9e-97 49
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-95 49
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-95 49
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 3e-74 45
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 4e-77 45
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 3e-96 45
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 1e-76 45
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 1e-76 45
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 9e-81 45
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 9e-81 45
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 8e-85 44
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 3e-79 44
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 9e-79 44
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 6e-79 44
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 9e-71 44
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 6e-74 43
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 6e-74 43
escN AAC38383.1 EscN Virulence LEE Protein 1e-79 43
escN AAC31513.1 L0034 Virulence LEE Protein 3e-80 43
escN CAC81862.1 EscN protein Virulence LEE II Protein 5e-78 43
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 3e-80 43
escN AAK26715.1 EscN Virulence LEE Protein 4e-78 43
escN AAL57542.1 EscN Virulence LEE Protein 4e-78 43
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-79 43
escN NP_290268.1 hypothetical protein Virulence LEE Protein 4e-80 43
ECs4568 NP_312595.1 EscN Virulence LEE Protein 4e-80 43
unnamed AAL06369.1 EscN Virulence LEE Protein 2e-77 43
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 8e-75 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 2e-80 42
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 8e-78 42
escN YP_003223475.1 translocator EscN Virulence LEE Protein 4e-78 42
escN CAI43874.1 EscN protein Virulence LEE Protein 3e-78 42
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 1e-68 42
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-69 41
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-69 41
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-69 41
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 2e-69 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0048 Protein 2e-99 50
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0515 Protein 1e-89 50
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG2144 Protein 5e-98 49
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0390 Protein 1e-96 48
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0192 Protein 5e-100 48
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG2499 Protein 4e-83 48
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG2331 Protein 1e-83 47
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG1254 Protein 2e-94 47
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0730 Protein 6e-80 43
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0812 Protein 2e-80 43
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG2459 Protein 9e-80 42
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG1778 Protein 4e-73 42
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG0555 Protein 7e-70 41
fliI NP_971825.1 flagellum-specific ATP synthase FliI VFG1008 Protein 4e-68 41