Gene Information

Name : hlgA (SAS1749)
Accession : YP_043865.1
Strain : Staphylococcus aureus MSSA476
Genome accession: NC_002953
Putative virulence/resistance : Virulence
Product : gamma-hemolysin component A precursor
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1898798 - 1899733 bp
Length : 936 bp
Strand : -
Note : Similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA or Hlg2 SWALL:HLGA_STAAM (SWALL:P31714) (309 aa) fasta scores: E(): 5.4e-84, 70.87% id in 309 aa

DNA sequence : 
ATGTTTAAGAAAAAAATGTTAGCTGCAACTTTGTCAGTAGGACTGATTGCACCTTTAGCATCTCCGATTCAAGAATCTAG
AGCAAATACTAATATTGAAAATATTGGTGATGGTGCTGAAGTAATCAAACGTACGGAGGATGTAAGTAGTAAGAAATGGG
GCGTTACTCAAAATGTCCAATTCGACTTTGTAAAAGATAAAAAATATAACAAAGACGCTTTAATTGTTAAAATGCAAGGT
TTTATTAATTCCAGAACTTCATTTTCAGATGTGAAGGGTAGTGGATATGAATTAACTAAACGAATGATTTGGCCATTCCA
ATATAATATAGGACTGACGACTAAAGATCCAAATGTTAGCTTAATCAATTACCTTCCTAAAAACAAAATAGAAACTACTG
ATGTTGGTCAAACATTAGGATATAACATTGGAGGTAATTTCCAGTCAGCACCATCTATAGGTGGCAATGGCTCATTTAAT
TATTCTAAAACAATTAGTTATACCCAAAAGAGTTATGTCAGTGAAGTAGACAAGCAAAACTCAAAATCTGTTAAATGGGG
TGTTAAAGCAAACGAATTTGTTACGCCTGATGGAAAAAAATCTGCGCATGATAGATATTTATTCGTACAAAGTCCAAATG
GTCCAACAGGTTCAGCAAGAGAATATTTTGCTCCTGATAATCAATTGCCACCTTTAGTTCAAAGTGGCTTTAATCCATCG
TTTATCACTACACTATCACATGAAAAAGGTTCAAGTGATACGAGTGAATTTGAAATTTCATATGGTAGAAACTTAGATAT
TACATATGCGACTTTATTCCCTAGAACTGGTATTTACGCAGAAAGAAAGCATAATGCATTTGTAAATAGAAACTTTGTAG
TTAGATATGAAGTTAATTGGAAAACACACGAAATTAAAGTGAAAGGACATAATTAA

Protein sequence : 
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lukE YP_494460.1 leukotoxin LukE Virulence vSa¥â Protein 2e-142 100
lukE YP_186708.1 leukotoxin LukE Virulence vSa¥â Protein 2e-142 100
lukE NP_646585.1 leukotoxin LukE Virulence vSa¥â Protein 2e-142 100
lukE NP_372344.1 leukotoxin S-subunit Virulence vSa¥â Protein 2e-142 100
lukE NP_374927.1 leukotoxin LukE Virulence vSa¥â Protein 2e-142 100
lukE YP_001332753.1 leukocidin LukE precursor Virulence vSa¥â Protein 2e-142 100
SAKOR_01768 YP_008491956.1 Leukocidin S subunit lukE Virulence vSa¥â Protein 2e-142 100
SAOV_1909 YP_005737354.1 leukocidin chain lukM precursor Virulence ¥ÕSa3 Protein 8e-110 74
lukS NP_646196.1 Panton-Valentine leukocidin chain S precursor Virulence ¥ÕSa2 Protein 5e-101 69
lukS-PV YP_494079.1 Panton-Valentine leukocidin, LukS-PV Virulence ¥ÕSa2 Protein 5e-101 69

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hlgA YP_043865.1 gamma-hemolysin component A precursor VFG1273 Protein 3e-106 71
hlgA YP_043865.1 gamma-hemolysin component A precursor VFG1277 Protein 2e-101 69
hlgA YP_043865.1 gamma-hemolysin component A precursor VFG1274 Protein 1e-90 68