Gene Information

Name : ermA1 (SAR0050)
Accession : YP_039522.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Resistance
Product : rRNA adenine N-6-methyltransferase 1
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0030
EC number : 2.1.1.48
Position : 55890 - 56621 bp
Length : 732 bp
Strand : +
Note : Previously sequenced as Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance protein, rRNA adenine N-6-methyltransferase ErmA SW:ERM1_STAAU (P06699) (243 aa) fasta scores: E(): 1.7e-90, 100.000% id in 243 aa. Similar to Streptococcus pyo

DNA sequence : 
ATGAACCAGAAAAACCCTAAAGACACGCAAAATTTTATTACTTCTAAAAAGCATGTAAAAGAAATATTGAATCACACGAA
TATCAGTAAACAAGACAACGTAATAGAAATCGGATCAGGAAAAGGACATTTTACCAAAGAGCTAGTCAAAATGAGTCGAT
CAGTTACTGCTATAGAAATTGATGGAGGCTTATGTCAAGTGACTAAAGAAGCGGTAAACCCCTCTGAGAATATAAAAGTG
ATTCAAACGGATATTCTAAAATTTTCCTTCCCAAAACATATAAACTATAAGATATATGGTAATATTCCTTATAACATCAG
TACGGATATTGTCAAAAGAATTACCTTTGAAAGTCAGGCTAAATATAGCTATCTTATCGTTGAGAAGGGATTTGCGAAAA
GATTGCAAAATCTGCAACGAGCTTTGGGTTTACTATTAATGGTGGAGATGGATATAAAAATGCTCAAAAAAGTACCACCA
CTATATTTTCATCCTAAGCCAAGTGTAGACTCTGTATTGATTGTTCTTGAACGACATCAACCATTGATTTCAAAGAAGGA
CTACAAAAAGTATCGATCTTTTGTTTATAAGTGGGTAAACCGTGAATATCGTGTTCTTTTCACTAAAAACCAATTCCGAC
AGGCTTTGAAGCATGCAAATGTCACTAATATTAATAAACTATCGAAGGAACAATTTCTTTCTATTTTCAATAGTTACAAA
TTGTTTCACTAA

Protein sequence : 
MNQKNPKDTQNFITSKKHVKEILNHTNISKQDNVIEIGSGKGHFTKELVKMSRSVTAIEIDGGLCQVTKEAVNPSENIKV
IQTDILKFSFPKHINYKIYGNIPYNISTDIVKRITFESQAKYSYLIVEKGFAKRLQNLQRALGLLLMVEMDIKMLKKVPP
LYFHPKPSVDSVLIVLERHQPLISKKDYKKYRSFVYKWVNREYRVLFTKNQFRQALKHANVTNINKLSKEQFLSIFNSYK
LFH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ermA BAC57474.1 rRNA methylase Not tested Type-IIIinv SCCmec Protein 3e-104 100
ermA BAA82205.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 3e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 Not tested Type-II SCCmec Protein 5e-104 100
ermA NP_370576.1 rRNA methylase Not tested Type-II SCCmec Protein 5e-104 100
ermA NP_373288.1 rRNA methylase Not tested Type-II SCCmec Protein 5e-104 100
ermA-3 YP_190052.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 5e-104 100
unnamed BAB47663.1 rRNA adenine N-6-methyltransferase Not tested Type-III SCCmec Protein 9e-104 99
unnamed BAC53825.1 rRNA adenine N-6-methyltransferase Not tested SRImec-III and SCCmec-III region Protein 9e-104 99
ermC NP_273130.1 rRNA adenine N-6-methyltransferase Not tested IHT-A Protein 5e-57 57

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_009782.5559229.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002758.1120012.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002952.2859614.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002745.1122822.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002745.1124324.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002745.1125313.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_009782.5559087.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002758.1121630.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002952.2859615.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002745.1123579.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_002745.1124852.p0 Protein 2e-104 100
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 AJ313523.1.orf0.gene Protein 5e-84 80
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 M64090.gene.p01 Protein 6e-61 62
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 M15332.gene.p01 Protein 6e-59 59
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 V01278.gene.p01 Protein 3e-58 59
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_010685.6295744.p0 Protein 2e-57 57
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_007209.3523503.p0 Protein 2e-57 57
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_007792.3912746.p0 Protein 9e-57 57
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 NC_010686.6295746.p0 Protein 2e-57 57
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 AM903082.gene3.p01 Protein 4e-48 52
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 AM410044.gene14.p01 Protein 4e-48 52
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 AM180355.1.gene2254. Protein 4e-47 51
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 AM180355.1.gene2259. Protein 4e-47 51