Gene Information

Name : mecA (SAR0039)
Accession : YP_039515.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Resistance
Product : penicillin-binding protein 2 prime
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0768
EC number : -
Position : 44919 - 46925 bp
Length : 2007 bp
Strand : -
Note : Identical to Staphylococcus epidermidis, and Staphylococcus aureus penicillin-binding protein 2 prime MecA TR:Q54113 (EMBL:X52592) (668 aa) fasta scores: E(): 0, 100.000% id in 668 aa, and to Staphylococcus sciuri methicillin resistanc protein MecA2 TR:O5

DNA sequence : 
ATGAAAAAGATAAAAATTGTTCCACTTATTTTAATAGTTGTAGTTGTCGGGTTTGGTATATATTTTTATGCTTCAAAAGA
TAAAGAAATTAATAATACTATTGATGCAATTGAAGATAAAAATTTCAAACAAGTTTATAAAGATAGCAGTTATATTTCTA
AAAGCGATAATGGTGAAGTAGAAATGACTGAACGTCCGATAAAAATATATAATAGTTTAGGCGTTAAAGATATAAACATT
CAGGATCGTAAAATAAAAAAAGTATCTAAAAATAAAAAACGAGTAGATGCTCAATATAAAATTAAAACAAACTACGGTAA
CATTGATCGCAACGTTCAATTTAATTTTGTTAAAGAAGATGGTATGTGGAAGTTAGATTGGGATCATAGCGTCATTATTC
CAGGAATGCAGAAAGACCAAAGCATACATATTGAAAATTTAAAATCAGAACGTGGTAAAATTTTAGACCGAAACAATGTG
GAATTGGCCAATACAGGAACAGCATATGAGATAGGCATCGTTCCAAAGAATGTATCTAAAAAAGATTATAAAGCAATCGC
TAAAGAACTAAGTATTTCTGAAGACTATATCAAACAACAAATGGATCAAAATTGGGTACAAGATGATACCTTCGTTCCAC
TTAAAACCGTTAAAAAAATGGATGAATATTTAAGTGATTTCGCAAAAAAATTTCATCTTACAACTAATGAAACAGAAAGT
CGTAACTATCCTCTAGGAAAAGCGACTTCACATCTATTAGGTTATGTTGGTCCCATTAACTCTGAAGAATTAAAACAAAA
AGAATATAAAGGCTATAAAGATGATGCAGTTATTGGTAAAAAGGGACTCGAAAAACTTTACGATAAAAAGCTCCAACATG
AAGATGGCTATCGTGTCACAATCGTTGACGATAATAGCAATACAATCGCACATACATTAATAGAGAAAAAGAAAAAAGAT
GGCAAAGATATTCAACTAACTATTGATGCTAAAGTTCAAAAGAGTATTTATAACAACATGAAAAATGATTATGGCTCAGG
TACTGCTATCCACCCTCAAACAGGTGAATTATTAGCACTTGTAAGCACACCTTCATATGACGTCTATCCATTTATGTATG
GCATGAGTAACGAAGAATATAATAAATTAACCGAAGATAAAAAAGAACCTCTGCTCAACAAGTTCCAGATTACAACTTCA
CCAGGTTCAACTCAAAAAATATTAACAGCAATGATTGGGTTAAATAACAAAACATTAGACGATAAAACAAGTTATAAAAT
CGATGGTAAAGGTTGGCAAAAAGATAAATCTTGGGGTGGTTACAACGTTACAAGATATGAAGTGGTAAATGGTAATATCG
ACTTAAAACAAGCAATAGAATCATCAGATAACATTTTCTTTGCTAGAGTAGCACTCGAATTAGGCAGTAAGAAATTTGAA
AAAGGCATGAAAAAACTAGGTGTTGGTGAAGATATACCAAGTGATTATCCATTTTATAATGCTCAAATTTCAAACAAAAA
TTTAGATAATGAAATATTATTAGCTGATTCAGGTTACGGACAAGGTGAAATACTGATTAACCCAGTACAGATCCTTTCAA
TCTATAGCGCATTAGAAAATAATGGCAATATTAACGCACCTCACTTATTAAAAGACACGAAAAACAAAGTTTGGAAGAAA
AATATTATTTCCAAAGAAAATATCAATCTATTAACTGATGGTATGCAACAAGTCGTAAATAAAACACATAAAGAAGATAT
TTATAGATCTTATGCAAACTTAATTGGCAAATCCGGTACTGCAGAACTCAAAATGAAACAAGGAGAAACTGGCAGACAAA
TTGGGTGGTTTATATCATATGATAAAGATAATCCAAACATGATGATGGCTATTAATGTTAAAGATGTACAAGATAAAGGA
ATGGCTAGCTACAATGCCAAAATCTCAGGTAAAGTGTATGATGAGCTATATGAGAACGGTAATAAAAAATACGATATAGA
TGAATAA

Protein sequence : 
MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVKDINI
QDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNV
ELANTGTAYEIGIVPKNVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETES
RNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKD
GKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTS
PGSTQKILTAMIGLNNKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFE
KGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKK
NIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQIGWFISYDKDNPNMMMAINVKDVQDKG
MASYNAKISGKVYDELYENGNKKYDIDE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
mecA YP_039515.1 penicillin-binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 100
mecA BAA82220.1 penicillin binding protein 2' Not tested Type-II SCCmec Protein 0.0 100
SAMSHR1132_00320 YP_005324556.1 penicillin-binding protein 2 prime Not tested Type-IIIinv SCCmec Protein 0.0 100
mecA NP_644846.1 penicillin binding protein 2 prime Not tested Type-IV SCCmec Protein 0.0 100
mecA NP_370565.1 penicillin binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 100
mecA NP_373278.1 penicillin binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 100
mecA YP_492752.1 penicillin-binding protein 2' Not tested Type-IV SCCmec Protein 0.0 100
mecA BAB72113.1 penicillin-binding protein 2' Not tested Type-IVa SCCmec Protein 0.0 100
mecA YP_190062.1 penicillin-binding protein 2' Not tested Type-II SCCmec Protein 0.0 100
mecA BAB72132.1 penicillin-binding protein 2' Not tested Type-IVb SCCmec Protein 0.0 100
mecA BAA86650.1 penicillin-binding protein 2' Not tested Type-I SCCmec Protein 0.0 99
mecA BAC57478.1 penicillin-binding protein 2' Not tested Type-IIIinv SCCmec Protein 0.0 99
mecA BAC67568.1 penicillin-binding protein 2' Not tested Type-IVc SCCmec Protein 0.0 99
mecA BAD24826.1 penicillin-binding protein 2' Not tested Type-V SCCmec Protein 0.0 99
unnamed ACL99850.1 penicillin binding protein 2a Not tested Type-V SCCmec Protein 0.0 99
mecA YP_184944.1 penicillin-binding protein 2' Not tested Type-I SCCmec Protein 0.0 99
SAPIG0042 YP_005732852.1 penicillin-binding protein 3 (pbp 3) (pspb20) Not tested Type-V SCCmec Protein 0.0 99
mecA YP_252006.1 penicillin binding protein 2 prime Not tested SCCmec Protein 0.0 99
mecA BAB47623.1 penicillin-binding protein 2' Not tested Type-III SCCmec Protein 0.0 99
mecA BAG06200.1 penicillin-binding protein 2' Not tested Type-VII SCCmec Protein 0.0 99
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein Not tested Type-XI SCCmec Protein 0.0 65

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mecA YP_039515.1 penicillin-binding protein 2 prime NC_007793.3913904.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_002745.1122812.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_009782.5559258.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_002952.2861157.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_002758.1120001.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_003923.1004781.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_010079.5776902.p0 Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime NC_002951.3236763.p0 Protein 0.0 99
mecA YP_039515.1 penicillin-binding protein 2 prime AB096217.gene.p01 Protein 0.0 99
mecA YP_039515.1 penicillin-binding protein 2 prime FR823292.1.gene3.p01 Protein 0.0 65