Gene Information

Name : ble (SAR0032)
Accession : YP_039509.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Resistance
Product : bleomycin resistance protein
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0346
EC number : -
Position : 40165 - 40569 bp
Length : 405 bp
Strand : -
Note : Previously sequenced as Staphylococcus aureus bleomycin resistance protein Ble TR:BAA82230 (EMBL:D86934) (134 aa) fasta scores: E(): 3.6e-57, 99.254% id in 134 aa. Similar to Bacillus subtilis hypothetical protein YraH TR:O07918 (EMBL:X92868) (128 aa) fas

DNA sequence :

GTGAGAATGTTACAGTCTATCCCGGCATTGCCAGTCGGGGATATTAAAAAGAGTATAGGTTTTTATTGCGATAAACTAGG
TTTCACTTTGGTTCACCATGAAGATGGATTCGCAGTTCTAATGTGTAATGAGGTTCGGATTCATCTATGGGAGGCAAGTG
ATGAAGGCTGGCGCTCTCGTAGTAATGATTCACCGGTTTGTACAGGTGCGGAGTCGTTTATTGCTGGTACTGCTAGTTGC
CGCATTGAAGTAGAGGGAATTGATGAATTATATCAACATATTAAGCCTTTGGGCATTTTGCACCCCAATACATCATTAAA
AGATCAGTGGTGGGATGAACGAGACTTTGCAGTAATTGATCCCGACAACAATTTGATTAGCTTTTTTCAACAAATAAAAA
GCTAA

Protein sequence :

MRMLQSIPALPVGDIKKSIGFYCDKLGFTLVHHEDGFAVLMCNEVRIHLWEASDEGWRSRSNDSPVCTGAESFIAGTASC
RIEVEGIDELYQHIKPLGILHPNTSLKDQWWDERDFAVIDPDNNLISFFQQIKS

• Homologs from PAI DB

Gene	GenBank Accn	Product	Virulance or Resistance	PAI or REI	Alignment Type	E-val	Identity
bleO	NP_373272.1	bleomycin resistance protein	Not tested	Type-II SCCmec	Protein	2e-59	100
ble	BAA82230.2	bleomycin resistance protein(BRP)	Not tested	Type-II SCCmec	Protein	2e-59	100
ble	YP_039509.1	bleomycin resistance protein	Not tested	Type-II SCCmec	Protein	2e-59	100
bleO	NP_370558.1	bleomycin resistance protein	Not tested	Type-II SCCmec	Protein	2e-59	100

• Homologs from CARD and BacMet (resistance genes)

Gene	GenBank Accn	Product	ID of source DB	Alignment Type	E-val	Identity
ble	YP_039509.1	bleomycin resistance protein	NC_002952.2859820.p0	Protein	8e-60	100
ble	YP_039509.1	bleomycin resistance protein	NC_005024.2598349.p0	Protein	1e-58	100
ble	YP_039509.1	bleomycin resistance protein	NC_002758.1119995.p0	Protein	8e-60	100
ble	YP_039509.1	bleomycin resistance protein	NC_009782.5559291.p0	Protein	8e-60	100
ble	YP_039509.1	bleomycin resistance protein	GQ149347.1.gene3.p1	Protein	1e-58	100
ble	YP_039509.1	bleomycin resistance protein	NC_012547.7751518.p0	Protein	1e-58	100
ble	YP_039509.1	bleomycin resistance protein	NC_002745.1122806.p0	Protein	8e-60	100