Gene Information

Name : hlgC (SAR2510)
Accession : YP_041860.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Virulence
Product : gamma-hemolysin component C precursor
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2584636 - 2585583 bp
Length : 948 bp
Strand : +
Note : Highly similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 8.6e-118, 97.77% id in 315 aa. Similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA SW:HLGA_STAAU (P31714

DNA sequence :
ATGCTTAAAAATAAAATATTAGCTACAACTTTATCTGTAAGCTTACTTGCCCCTCTTGCCAATCCGTTATTAGAAAATGC
TAAAGCTGCCAATGATACTGAAGACATCGGTAAAGGAAACGATGTAGAAATTATCAAAAGGACAGAAGATAAAACAAGTA
ATAAATGGGGCGTGACTCAAAATATCCAATTCGACTTTGTGAAGGATAAAAAATATAACAAAGATGCTTTGATCTTAAAG
ATGCAAGGATTCATTAGCTCTCGAACAACATATTATAACTATAAAAATACAAATCATATTAAATCTATGCGTTGGCCATT
CCAATATAATATTGGTTTGAAAACAAATGATAAATATGTTTCTTTAATCAATTATTTACCGAAAAATAAAATTGAATCTA
CAAACGTAAGTCAGACATTAGGATACAATATTGGTGGTAATTTCCAATCAGCCCCATCACTTGGTGGTAATGGATCATTT
AACTATTCTAAATCGATTAGCTATACACAACAAAATTATGTAAGTGAAGTAGAACAACAAAACTCAAAAAGTGTTTTATG
GGGCGTCAAAGCGAATTCATTCGCCACTGAATCAGGTCAAAAATCAGCATTTGATAGCGATTTATTTGTAGGCTACAAAC
CTCATAGTAAAGATCCTAGAGATTATTTCGTTCCAGACAGCGAGTTACCACCTCTTGTACAAAGTGGATTTAACCCTTCA
TTTATCGCAACAGTATCTCACGAAAAAGGTTCAAGCGACACGAGCGAATTTGAAATCACTTATGGAAGAAATATGGATGT
CACTCATGCCATTAAAAGATCAACACATTATGGCAACAGTTATTTAGATGGTCACAGAGTCCATAATGCATTTAAAAATA
GAAACTACACTGTGAAATATGAAGTCAATTGGAAGACTCACGAAATCAAAGTGAAAGGACAGAATTGA

Protein sequence :
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGNDVEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILK
MQGFISSRTTYYNYKNTNHIKSMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSF
NYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPS
FIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFKNRNYTVKYEVNWKTHEIKVKGQN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lukS NP_646196.1 Panton-Valentine leukocidin chain S precursor Virulence ¥ÕSa2 Protein 2e-112 77
lukS-PV YP_494079.1 Panton-Valentine leukocidin, LukS-PV Virulence ¥ÕSa2 Protein 2e-112 77
lukE NP_374927.1 leukotoxin LukE Virulence vSa¥â Protein 1e-87 67
lukE YP_001332753.1 leukocidin LukE precursor Virulence vSa¥â Protein 1e-87 67
lukE YP_494460.1 leukotoxin LukE Virulence vSa¥â Protein 1e-87 67
lukE YP_186708.1 leukotoxin LukE Virulence vSa¥â Protein 1e-87 67
lukE NP_646585.1 leukotoxin LukE Virulence vSa¥â Protein 1e-87 67
lukE NP_372344.1 leukotoxin S-subunit Virulence vSa¥â Protein 1e-87 67
SAKOR_01768 YP_008491956.1 Leukocidin S subunit lukE Virulence vSa¥â Protein 1e-87 67
SAOV_1909 YP_005737354.1 leukocidin chain lukM precursor Virulence ¥ÕSa3 Protein 1e-85 65

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hlgC YP_041860.1 gamma-hemolysin component C precursor VFG1274 Protein 1e-132 99
hlgC YP_041860.1 gamma-hemolysin component C precursor VFG1277 Protein 8e-113 77
hlgC YP_041860.1 gamma-hemolysin component C precursor VFG1273 Protein 1e-88 69