Gene Information

Name : hlgA (SAR2509)
Accession : YP_041859.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Virulence
Product : gamma-hemolysin component A precursor
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2583157 - 2584086 bp
Length : 930 bp
Strand : +
Note : Highly similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA SW:HLGA_STAAU (P31714) (309 aa) fasta scores: E(): 3.1e-115, 99.35% id in 309 aa. Similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716

DNA sequence :
ATGATTAAAAATAAAATATTAACAGCAACTTTAGCAGTTGGTTTAATCGCCCCTTTAGCCAATCCATTTATAGAAATTTC
TAAAGCAGAAAATAAGATAGAAGATATCGGCCAAGGTGCAGAAATCATCAAAAGAACACAAGACATTACTAGCAAACGAT
TAGCTATAACTCAAAACATTCAATTTGATTTTGTAAAAGATAAAAAATATAACAAAGATGCCCTAGTTGTTAAGATGCAA
GGCTTCATCAGCTCTAGAACAACATATTCAGACTTAAAAAAATATCCATATATTAAAAGAATGATATGGCCATTTCAATA
TAATATCAGTTTGAAAACGAAAGACTCTAATGTTGATTTAATCAATTATCTTCCTAAAAATAAAATTGATTCAGCAGATG
TTAGTCAGAAATTAGGCTATAATATCGGCGGAAACTTCCAATCAGCGCCATCAATCGGAGGCAGTGGCTCATTCAACTAC
TCTAAAACAATTAGTTATAATCAAAAAAACTATGTTACTGAAGTAGAAAGTCAGAACTCTAAAGGTGTTAAATGGGGAGT
GAAAGCAAATTCATTCGTTACACCGAATGGTCAAGTATCTGCATATGATCAATACTTATTTGCACAAGACCCAACTGGTC
CAGCAGCAAGAGACTATTTCGTCCCAGATAATCAACTACCTCCTTTAATTCAAAGTGGCTTTAATCCATCATTTATTACA
ACATTGTCACACGAAAAAGGTAAAGGTGATAAAAGCGAGTTTGAAATCACTTACGGCAGAAACATGGATACTACATATGC
ATACGTGACAAGACATCGTTTAGCCGTTGATAGAAAACATGATGCTTTTAAAAACCGAAACGTTACAGTTAAATATGAAG
TGAACTGGAAAACACATGAAGTAAAAATTAAAAGCATCACACCTAAGTAA

Protein sequence :
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQ
GFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNY
SKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFIT
TLSHEKGKGDKSEFEITYGRNMDTTYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lukE NP_374927.1 leukotoxin LukE Virulence vSa¥â Protein 4e-106 71
lukE YP_001332753.1 leukocidin LukE precursor Virulence vSa¥â Protein 4e-106 71
lukE YP_494460.1 leukotoxin LukE Virulence vSa¥â Protein 4e-106 71
lukE YP_186708.1 leukotoxin LukE Virulence vSa¥â Protein 4e-106 71
lukE NP_646585.1 leukotoxin LukE Virulence vSa¥â Protein 4e-106 71
lukE NP_372344.1 leukotoxin S-subunit Virulence vSa¥â Protein 4e-106 71
SAKOR_01768 YP_008491956.1 Leukocidin S subunit lukE Virulence vSa¥â Protein 4e-106 71
lukS NP_646196.1 Panton-Valentine leukocidin chain S precursor Virulence ¥ÕSa2 Protein 4e-95 67
lukS-PV YP_494079.1 Panton-Valentine leukocidin, LukS-PV Virulence ¥ÕSa2 Protein 4e-95 67
SAOV_1909 YP_005737354.1 leukocidin chain lukM precursor Virulence ¥ÕSa3 Protein 3e-98 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hlgA YP_041859.1 gamma-hemolysin component A precursor VFG1273 Protein 2e-141 99
hlgA YP_041859.1 gamma-hemolysin component A precursor VFG1274 Protein 3e-90 69
hlgA YP_041859.1 gamma-hemolysin component A precursor VFG1277 Protein 2e-95 67