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Name : ureC (SAR2374) Accession : YP_041729.1 Strain : Staphylococcus aureus MRSA252 Genome accession: NC_002952 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 2442301 - 2444016 bp Length : 1716 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGCTTTAAAATGACGCAAAATCAATATACGAGCTTATACGGTCCAACTGTTGGAGATTCTATTCGTTTAGGTGATAC GAATCTATTTGCTCAAATTGAAAAAGACTATGCGGTTTATGGTGAAGAAGCTACTTTTGGTGGTGGTAAATCTATTAGAG ACGGTATGGCGCAAAATCCTCGTGTAACACGTGATGATGTGAACGTTGCAGACCTTGTCATTTCTAATGCCGTTATTATC GATTACGATAAAGTGGTTAAAGCTGATATAGGCATTAAAAATGGTTATATTTTCGCCATAGGTAATGCCGGCAACCCAGA TATAATGGATAATGTCGACATTATTATAGGTTCAACAACAGATATCATTGCCGCTGAAGGTAAAATCGTCACTGCTGGTG GTATTGATACTCATGTTCATTTTATTAATCCTGAACAAGCAGAAGTCGCATTAGAAAGTGGTATTACGACTCATATTGGT GGTGGTACTGGTGCTTCAGAAGGTTCTAAAGCAACTACTGTAACTCCAGGTCCATGGCATATTCATAGAATGTTAGAAGC TGCCGAAGGTTTACCGATTAATGTCGGTTTTACAGGTAAAGGACAAGCAACAAATCCAACTGCACTCATTGAACAAATCA ATGCCGGAGCAATTGGATTAAAAGTACATGAAGACTGGGGTGCAACACCATCTGCTTTGAGTCATGCATTAGATGTTGCT GATGAATTTGATGTTCAAATTGCATTACATGCAGATACTTTAAATGAAGCAGGATTTATGGAAGACACAATGGCTGCTGT TAAAGACCGTGTACTTCATATGTACCATACTGAAGGTGCTGGTGGCGGTCATGCGCCTGATTTAATTAAATCCGCTGCAT TTCCAAATATTTTACCTTCATCTACAAATCCAACTTTGCCTTATACACATAATACTGTAGATGAACATTTAGATATGGTA ATGATTACTCACCATTTAAATGCGGCTATTCCTGAAGATATCGCATTCGCAGATTCACGTATTCGTAAAGAAACGATTGC AGCTGAAGATGTTCTGCAAGATATGGGTGTATTCAGTATGATTAGTTCCGATTCACAGGCAATGGGCCGTGTAGGTGAAG TAATTACACGAACATGGCAAGTAGCACATCGCATGAAAGAACAACGTGGTCCTTTAGATGGTGATTATGTACATAATGAT AATAATCGTATCAAACGTTATATCGCTAAATATACAATTAACCCAGCAATTACACATGGTATTTCTGAATATGTAGGATC TATCGAGCCGGGCAAACTAGCTGATATTGTCTTATGGGATCCAATTTTCTTTGGTGTTAAACCTGAATTAGTTGTAAAGG GCGGATTAATTAACTCTGCCGTAAATGGTGATGCAAATGGTTCTATACCTACATCTGAACCGATGAAGTACCGTAAAATG TATGGTCAATACGGCGGAAACCTTACAAGTACGTCAATGACATTCGTGTCTAAAACTGCTTATGAAAATGGTATCAATCG TGCATTAAATTTAAAACGCATGGTGCGTCCAGTTAAAAATATTAGACAATTATCTAAAGCAGATATGAAAAATAACAGCG CAACACCTAAATTAGACGTTGATCCACAAACATATGAAGTATATGTAGATGGAGAAAAAATTACAAGTAATGCAGCAACT GAGTTACCATTAACTCAAAGATACTTCTTATTCTAG Protein sequence : MSFKMTQNQYTSLYGPTVGDSIRLGDTNLFAQIEKDYAVYGEEATFGGGKSIRDGMAQNPRVTRDDVNVADLVISNAVII DYDKVVKADIGIKNGYIFAIGNAGNPDIMDNVDIIIGSTTDIIAAEGKIVTAGGIDTHVHFINPEQAEVALESGITTHIG GGTGASEGSKATTVTPGPWHIHRMLEAAEGLPINVGFTGKGQATNPTALIEQINAGAIGLKVHEDWGATPSALSHALDVA DEFDVQIALHADTLNEAGFMEDTMAAVKDRVLHMYHTEGAGGGHAPDLIKSAAFPNILPSSTNPTLPYTHNTVDEHLDMV MITHHLNAAIPEDIAFADSRIRKETIAAEDVLQDMGVFSMISSDSQAMGRVGEVITRTWQVAHRMKEQRGPLDGDYVHND NNRIKRYIAKYTINPAITHGISEYVGSIEPGKLADIVLWDPIFFGVKPELVVKGGLINSAVNGDANGSIPTSEPMKYRKM YGQYGGNLTSTSMTFVSKTAYENGINRALNLKRMVRPVKNIRQLSKADMKNNSATPKLDVDPQTYEVYVDGEKITSNAAT ELPLTQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-178 | 64 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-179 | 64 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-179 | 64 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-179 | 64 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-173 | 63 |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-173 | 63 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_041729.1 | urease subunit alpha | VFG0270 | Protein | 8e-158 | 58 |
