Gene Information

Name : chp (SAR2036)
Accession : YP_041409.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Virulence
Product : chemotaxis-inhibiting protein CHIPS
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2126786 - 2127235 bp
Length : 450 bp
Strand : +
Note : secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial

DNA sequence : 
ATGAAAAAGAAATTAGCAACAACAGTTTTAGCATTAAGTTTTTTAACGGCAGGAATCAGTACACACCATCATTCAGCGAA
AGCTTTTACTTTTGAACCGTTTCCTACAAATGAAGAAATAGAATCAAATAAGAAAATGTTAGAGAAAGAAAAAGCTTATA
AAGAATCATTTAAAAATAGTGGTCTTCCTACAACGCTAGGAAAATTAGATGAACGTTTGAGAAATTATTTAAAGAAAGGC
ACAAAAAATTCTGCTCAATTTGAAAAAATGGTTATTTTAACTGAAAATAAAGGTTACTATACAGTATATCTGAATACACC
ACTTGCTGAAGATAGAAAAAATGTTGAGTTACTAGGTAAAATGTATAAAACATACTTCTTTAAAAAAGGAGAGTCTAAAT
CATCTTATGTAATTAATGGTCCTGGAAAAACTAATGAATATGCATACTAA

Protein sequence : 
MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKMLEKEKAYKESFKNSGLPTTLGKLDERLRNYLKKG
TKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAKOR_01920 YP_008492108.1 Chemotaxis-inhibiting protein Chips Not tested ¥ÕSa3 Protein 1e-63 100
chs YP_494571.1 chemotaxis-inhibiting protein CHIPS Not tested ¥ÕSa3 Protein 1e-63 100
chs YP_494571.1 chemotaxis-inhibiting protein CHIPS Not tested ¥ÕSa3 Protein 1e-63 100
SA1755 NP_375050.1 chemotaxis-inhibiting protein CHIPS Not tested ¥ÕSa3 Protein 4e-63 99

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
chp YP_041409.1 chemotaxis-inhibiting protein CHIPS VFG2422 Protein 3e-64 100