Gene Information

Name : hysA1 (SAR1892)
Accession : YP_041274.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Virulence
Product : hyaluronate lyase precursor 1
Function : -
COG functional category : -
COG ID : -
EC number : 4.2.2.1
Position : 1975037 - 1977457 bp
Length : 2421 bp
Strand : +
Note : Similar to Staphylococcus aureus hyaluronate lyase precursor HysA SW:HYSA_STAAU (Q59801) (807 aa) fasta scores: E(): 0, 75.8% id in 810 aa, and to Streptococcus pneumoniae hyaluronate lyase precursor SP0314 SW:HYSA_STRPN (Q54873) (949 aa) fasta scores: E(

DNA sequence :
ATGACAAATAAAATGAAGAAATGGCAAAAATTATCCACCATTACGTTATTAATGACCGGAGTGATTGCTTTAAATAATGG
TGAATTTAGAAATGTTGATAAACATCAAATCGCTGTGGCTGATACGAATGTTCAAACGCCAGATTATGAAAAATTGAAGA
AGACGTGGCTCGACGTTAACTACGGTTATGATCAGTATGATGAGAATAATCAAGATATGAAGAAGAAGTTTGATGCTAAA
GAAAAAGAAGCCAAGAAGTTACTTGATGACATGAAAACTGATACGAATAGAACATATTTGTGGTCAGGAGCTGAAAACCT
TGAAACTAATTCTTCTCACATGACAAAAACCTATCGTAATATCGAGAAAATCGCAGAATCAATGCAACATAAGAATACGG
TATTAAAAACAGTTGAAAACAAGTTGAAAATAAAAGAAGCCCTAGATTGGATGCACAAAAATGTTTATGGCAAGAATCCT
TCTCAAAAAGTCGAGGATTTAACTAAAAATCGTAAGGGGCAAACTACACCCAAGAATAACTCATTGAATTGGTGGGATTA
TGAAATTGGTACGCCAAGAGCATTAACAAATACACTACTTCTAATGGATGATATGCTCACTAAAGATGAAATGAAAAATT
ATTCAAAACCTATTAGTACATATGCACCATCCAGTGACAAAATTTTATCTTCTGTTGGTGAATCAGAAGATGCTAAAGGT
GGAAATTTAGTGGACATTTCTAAAGTAAAACTTTTAGAAAGTGTTATTGAAGAAGATGTAGATATGTTGAAAAAGTCTAT
AGATTCTTTTAATAAAGTGTTCACTTATGTTCAAGATTCTGCCACTGGTAAAGGTCGCAATGGATTCTATAAAGATGGCT
CTTACATTGATCATCAAGATGTCCCTTACACTGGTGCTTATGGTGTTGTACTATTAGAGGGTATTTCTCAAATGATGCCG
ATGATAAAAGAATCTCCTTTTAAAACTACACAAGATAATGCTACATTAAGCAATTGGATTGACGAAGGGTTTATGCCATT
AATCTATAAAGGTGAAATGATGGATTTATCACGAGGTAGAGCTATCAGTCGTGAAAATGAAACGAGTCATACAGCGTCAG
CGACTGTAATGAAATCATTGTTGAGATTGAATGATACCATGGATGATTCAACAAAAACTAGATATAAGCAAATCGTTAAA
ACTTCTGTTAATTCTGATTCAAGTTACAACCAAAATAATTATTTAAATTCATATTCAGACATAGCTAAAATGAAAAAGTT
AATGAATGATAGTACTATTTCTAAAAACGATTTAACACAGCAACTTAAAATATATAATGACATGGATCGTGTCACCTATC
ACAATAAAGACCTGGACTTTGCATTTGGTTTAAGTATGACATCGAAAAACATCGCACGATACGAAAATATCAACGGAGAG
AACTTAAAAGGTTGGCACACCGGTGCAGGCATGTCTTATTTATATAACAGCGATGTCAAACACTATCGCGATAACTTCTG
GGCAACAGCCGATATGACTTGTCTTCCAGGCACTACTACTTTAAATGATATGCCATCTACTAATACTAAGAATGATAAAT
CTTTTGTTGGCGGGACAAAATTAAATAATAAATACGCAAGCATCGGTATGGATTTTGAAAATCAGGACAAAACTTTAACT
GCCAAAAAATCATATTTCATATTAAACGATAAAATTGTCTTCTTAGGAACTGGCATTAAAAGTACTGATTCATCAAAGAA
TCCAGTTACAAGTGTTGAAAATCGCAAAGCAAATGGGTATAAATTATTTAAAGATGATATTGAAATTACCACTTCAGATG
TTAATGCTCAGGAAACCCATTCAGTCTTTTTAGAGTCCAACGATACTAAAAAGAACATTGGTTATCATTTCTTAGACAAG
CCAAAAATAACTGTAAAAAAAGAAAGTCATACTGGTAAGTGGAGTGAAATTAATAAAAGTCAAAAAAAAGATGACAAAAA
AGATGAGTATTATGAAGTAACTCAAACACATAATACATCTGACAGTAAATATGCATATGTTTTGTATCCTGGTTTATCAA
AAAGTGATTTTAAATCGAAGAATAATAATGTAAGTATTGTTAAACAAGATGAAGATTTTCATGTGATAAAAGATAATGAT
GGCGTATTTGCTGGGGTTAATTATAGTGATAATACTAAATCTTTTGATATAAACGGAATTACTGTTGAATTAAAAGAAAA
AGGCATGTTTGTAATTAAAAAGAAAGATGATAAAGCATATAAATGTAGCTTCTATAATCCTGAAACTACAAATACCGCTT
CAAATATAGAATCAAAAATTTTTATTAAAGGTTACACCATAACTAATAAAAGTGTCATAAACTCTAATGATGCTGGTGTA
AACTTTGAATTAACTAAATAA

Protein sequence :
MTNKMKKWQKLSTITLLMTGVIALNNGEFRNVDKHQIAVADTNVQTPDYEKLKKTWLDVNYGYDQYDENNQDMKKKFDAK
EKEAKKLLDDMKTDTNRTYLWSGAENLETNSSHMTKTYRNIEKIAESMQHKNTVLKTVENKLKIKEALDWMHKNVYGKNP
SQKVEDLTKNRKGQTTPKNNSLNWWDYEIGTPRALTNTLLLMDDMLTKDEMKNYSKPISTYAPSSDKILSSVGESEDAKG
GNLVDISKVKLLESVIEEDVDMLKKSIDSFNKVFTYVQDSATGKGRNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMP
MIKESPFKTTQDNATLSNWIDEGFMPLIYKGEMMDLSRGRAISRENETSHTASATVMKSLLRLNDTMDDSTKTRYKQIVK
TSVNSDSSYNQNNYLNSYSDIAKMKKLMNDSTISKNDLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNIARYENINGE
NLKGWHTGAGMSYLYNSDVKHYRDNFWATADMTCLPGTTTLNDMPSTNTKNDKSFVGGTKLNNKYASIGMDFENQDKTLT
AKKSYFILNDKIVFLGTGIKSTDSSKNPVTSVENRKANGYKLFKDDIEITTSDVNAQETHSVFLESNDTKKNIGYHFLDK
PKITVKKESHTGKWSEINKSQKKDDKKDEYYEVTQTHNTSDSKYAYVLYPGLSKSDFKSKNNNVSIVKQDEDFHVIKDND
GVFAGVNYSDNTKSFDINGITVELKEKGMFVIKKKDDKAYKCSFYNPETTNTASNIESKIFIKGYTITNKSVINSNDAGV
NFELTK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hysA1 YP_041274.1 hyaluronate lyase precursor 1 Virulence vSa¥â Protein 0.0 100

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hysA1 YP_041274.1 hyaluronate lyase precursor 1 VFG1315 Protein 0.0 75