Gene Information

Name : blaZ (SAR1831)
Accession : YP_041217.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Resistance
Product : beta-lactamase precursor
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG2367
EC number : 3.5.2.6
Position : 1913827 - 1914672 bp
Length : 846 bp
Strand : +
Note : Similar to Staphylococcus aureus beta-lactamase precursor BlaZ SW:BLAC_STAAU (P00807) (281 aa) fasta scores: E(): 2.6e-94, 99.644% id in 281 aa, and to Bacillus licheniformis beta-lactamase precursor PenP SW:BLAC_BACLI (P00808) (307 aa) fasta scores: E():

DNA sequence :
TTGAAAAAGTTAATATTTTTAATTGTAATTGCTTTAGTTTTAAGTGCATGTAATTCAAACAGTTCACATGCCAAAGAGTT
AAATGATTTAGAAAAAAAATATAATGCTCATATTGGTGTTTATGCTTTAGATACTAAAAGTGGTAAGGAAGTAAAATTTA
ATTCAGATAAGAGATTTGCCTATGCTTCAACTTCAAAAGCGATAAATAGTGCTATTTTGTTAGAACAAGTACCTTATAAT
AAGTTAAATAAAAAAGTACATATTAACAAAGATGATATAGTTGCTTATTCTCCTATTTTAGAAAAATATGTAGGAAAAGA
TATCACTTTAAAAGCACTTATTGAGGCTTCAATGACATATAGTGATAATACAGCAAACAATAAAATTATAAAAGAAATCG
GTGGAATCAAAAAAGTTAAACAACGTCTAAAAGAACTAGGAGATAAAGTAACAAATCCAGTTAGATATGAGATAGAATTA
AATTACTATTCACCAAAGAGCAAAAAAGATACTTCAACACCTGCTGCTTTCGGTAAGACTTTAAATAAACTTATCGCAAA
TGGAAAATTAAGCAAAGAAAACAAAAAATTCTTACTTGATTTAATGTTAAATAATAAAAGCGGAGATACTTTAATTAAAG
ACGGTGTTCCAAAAGACTATAAGGTTGCTGATAAAAGTGGTCAAGCAATAACATATGCTTCTAGAAATGATGTTGCTTTT
GTTTATCCTAAGGGCCAATCTGAACCTATTGTTTTAGTCATTTTTACGAATAAAGACAATAAAAGTGATAAGCCAAATGA
TAAGTTGATAAGTGAAACCGCCAAGAGTGTAATGAAGGAATTTTAA

Protein sequence :
MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYN
KLNKKVHINKDDIVAYSPILEKYVGKDITLKALIEASMTYSDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIEL
NYYSPKSKKDTSTPAAFGKTLNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASRNDVAF
VYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
blaZ YP_253679.1 beta-lactamase Not tested ¥ÕSh1 Protein 1e-111 100
blaZ YP_005754040.1 beta-lactamase Not tested Type-XI SCCmec Protein 1e-82 68

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
blaZ YP_041217.1 beta-lactamase precursor NC_005054.2598287.p0 Protein 6e-112 100
blaZ YP_041217.1 beta-lactamase precursor M60253.gene.p01 Protein 6e-112 100
blaZ YP_041217.1 beta-lactamase precursor NC_002952.2859819.p0 Protein 6e-112 100
blaZ YP_041217.1 beta-lactamase precursor NC_003140.1122765.p0 Protein 6e-110 99
blaZ YP_041217.1 beta-lactamase precursor NC_007931.3978604.p0 Protein 6e-110 99
blaZ YP_041217.1 beta-lactamase precursor NC_005011.2598316.p0 Protein 1e-109 98
blaZ YP_041217.1 beta-lactamase precursor NC_005127.2610354.p0 Protein 9e-110 98
blaZ YP_041217.1 beta-lactamase precursor NC_005951.2853409.p0 Protein 1e-109 98
blaZ YP_041217.1 beta-lactamase precursor NC_010063.5774822.p0 Protein 7e-110 98
blaZ YP_041217.1 beta-lactamase precursor NC_010066.5774791.p0 Protein 1e-104 97
blaZ YP_041217.1 beta-lactamase precursor FR823292.1.gene2.p01 Protein 5e-83 68
blaZ YP_041217.1 beta-lactamase precursor HE993884.1.gene8.p01 Protein 3e-69 67