Gene Information

Name : spc2 (SAR1736)
Accession : YP_041124.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Resistance
Product : streptomycin 3''-adenylyltransferase 2
Function : -
COG functional category : R : General function prediction only
COG ID : COG1708
EC number : 2.7.7.47
Position : 1797370 - 1798152 bp
Length : 783 bp
Strand : -
Note : Identical to Staphylococcus aureus streptomycin 3''-adenylyltransferase Spc SW:S3AD_STAAU (P04827) (260 aa) fasta scores: E(): 3.5e-100, 100.000% id in 260 aa. Similar to Streptomyces coelicolor nucleotidyltransferase SCD19.10 TR:Q9F2Z2 (EMBL:AL392149) (2

DNA sequence :
ATGAGCAATTTGATTAACGGAAAAATACCAAATCAAGCGATTCAAACATTAAAAATCGTAAAAGATTTATTTGGAAGTTC
AATAGTTGGAGTATATCTATTTGGTTCAGCAGTAAATGGTGGTTTACGCATTAACAGCGATGTAGATGTTCTAGTCGTCG
TGAATCATAGTTTACCTCAATTAACTCGAAAAAAACTAACAGAAAGACTAATGACTATATCAGGAAAGATTGGAAATACG
GATTCTGTTAGACCACTTGAAGTTACGGTTATAAATAGGAGTGAAGTTGTCCCTTGGCAATATCCTCCAAAAAGAGAATT
TATATACGGTGAGTGGCTCAGGGGTGAATTTGAGAATGGACAAATTCAGGAACCAAGCTATGATCCTGATTTGGCTATTG
TTTTAGCACAAGCAAGAAAGAATAGTATTTCTCTATTTGGTCCTGATTCTTCAAGTATACTTGTCTCCGTACCTTTGACA
GATATTCGAAGAGCAATTAAGGATTCTTTGCCAGAACTAATTGAGGGGATAAAAGGTGATGAGCGTAATGTAATTTTAAC
CCTAGCTCGAATGTGGCAAACAGTGACTACTGGTGAAATTACCTCGAAAGATGTCGCTGCAGAATGGGCTATACCTCTTT
TACCTAAAGAGCATGTAACTTTACTGGATATAGCTAGAAAAGGCTATCGGGGAGAGTGTGATGATAAGTGGGAAGGACTA
TATTCAAAGGTGAAAGCACTCGTTAAGTATATGAAAAATTCTATAGAAACTTCTCTCAATTAG

Protein sequence :
MSNLINGKIPNQAIQTLKIVKDLFGSSIVGVYLFGSAVNGGLRINSDVDVLVVVNHSLPQLTRKKLTERLMTISGKIGNT
DSVRPLEVTVINRSEVVPWQYPPKREFIYGEWLRGEFENGQIQEPSYDPDLAIVLAQARKNSISLFGPDSSSILVSVPLT
DIRRAIKDSLPELIEGIKGDERNVILTLARMWQTVTTGEITSKDVAAEWAIPLLPKEHVTLLDIARKGYRGECDDKWEGL
YSKVKALVKYMKNSIETSLN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
spc BAA82204.1 O-nucleotydiltransferase(9) Not tested Type-II SCCmec Protein 9e-119 100
spc1 YP_039523.1 streptomycin 3''-adenylyltransferase 1 Not tested Type-II SCCmec Protein 1e-118 100
ant(9) NP_370577.1 O-nucleotidylltransferase Not tested Type-II SCCmec Protein 1e-118 100
ant(9) NP_373289.1 O-nucleotidylltransferase(9) Not tested Type-II SCCmec Protein 1e-118 100
spC YP_190051.1 streptomycin 3''-adenylyltransferase Not tested Type-II SCCmec Protein 1e-118 100
ant(9) BAC57473.1 O-nucleotidyltransferase(9) Not tested Type-IIIinv SCCmec Protein 9e-119 100

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002952.2859154.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002745.1123578.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002745.1124853.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_009782.5559472.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002758.1120013.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002952.2859153.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002745.1122823.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002745.1124325.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002745.1125314.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 GU235985.1.orf1.gene Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_009782.5559439.p0 Protein 6e-119 100
spc2 YP_041124.1 streptomycin 3''-adenylyltransferase 2 NC_002758.1121631.p0 Protein 6e-119 100