Gene Information

Name : thyA (SAR1440)
Accession : YP_040842.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1497785 - 1498741 bp
Length : 957 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTTGAATTCATTTGATGCAGCATATCACAGTCTTTGTGAAGAAGTTTTAGAAATAGGAAATACACGAAATGATCGCAC
AAATACAGGTACGATTTCGAAATTTGGTCATCAACTTCGCTTTGACTTATCTAAAGGATTTCCACTATTAACGACAAAGA
AAGTTTCTTTTAAATTAGTAGCGACCGAATTATTATGGTTCATTAAAGGAGATACAAATATCCAATACTTATTAAAGTAT
AATAATAATATTTGGAACGAATGGGCTTTTGAAAATTATATCAAATCAGACGAGTATAAAGGTCCAGATATGACAGATTT
CGGGCATCGTGCATTGAGTGATCCTGAATTTAACGAACAATATAAAGAACAAATGAAACAATTTAAGCAACGTATTCTTG
AAGATGATACATTTGCGAAGCAATTCGGTGATTTAGGAAATGTTTATGGTAAACAGTGGCGAGATTGGGTTGATAAAGAT
GGTAATCATTTTGATCAACTTAAAACAGTAATTGAGCAAATTAAGCATAATCCAGATTCAAGACGACACATCGTATCTGC
ATGGAATCCAACAGAAATTGATACAATGGCACTTCCGCCTTGTCATACAATGTTCCAGTTTTATGTTCAAGATGGTAAGT
TAAGTTGCCAGTTATACCAACGTAGCGCAGATATCTTTTTAGGTGTGCCATTTAATATCGCAAGCTACGCTTTATTGACG
CACCTTATTGCCAAAGAATGTGGACTTGAAGTAGGAGAATTTGTGCATACATTTGGAGATGCACATATTTATTCAAATCA
TATTGATGCGATTCAAACACAATTAGCACGTGAAAGCTTCAATCCTCCAACATTAAAAATTAACAGTGATAAGTCTATTT
TTGACATAAATTATGAAGATTTGGAAATTGTTGACTATGAATCACATCCAGCAATAAAAGCTCCAATAGCAGTGTAG

Protein sequence :
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKY
NNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKD
GNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLT
HLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-131 86