Gene Information

Name : dfrB (SAR1439)
Accession : YP_040841.1
Strain : Staphylococcus aureus MRSA252
Genome accession: NC_002952
Putative virulence/resistance : Unknown
Product : dihydrofolate reductase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : 1.5.1.3
Position : 1497106 - 1497585 bp
Length : 480 bp
Strand : -
Note : Previously sequenced as Staphylococcus aureus trimethoprim-sensitive dihydrofolate reductase type I DfrB SW:DYRB_STAAU (P10167) (158 aa) fasta scores: E(): 3.1e-62, 100.000% id in 158 aa. Similar to Staphylococcus epidermidis dihydrofolate reductase DfrC

DNA sequence :
ATGACTTTATCCATTCTAGTTGCACATGACTTGCAACGAGTAATTGGTTTTGAAAATCAATTACCTTGGCACCTACCAAA
TGATTTGAAGCATGTTAAAAAATTATCAACAGGTCATACTTTAGTAATGGGTCGTAAGACATTTGAATCGATTGGTAAAC
CACTACCGAATCGTCGAAATGTTGTACTTACTTCAGATACAAGTTTCAACGTAGAGGGCGTTGATGTAATTCATTCTATT
GAAGATATTTACCAACTACCGGGCCATGTTTTTATATTTGGAGGGCAAACATTATTTGAAGAAATGATTGATAAAGTGGA
CGACATGTATATTACTGTTATTGAAGGTAAATTTCGTGGTGATACGTTCTTTCCACCTTATACATTTGAAGACTGGGAAG
TTGCCTCTTCAGTTGAAGGTAAACTAGATGAGAAAAATACAATTCCACATACCTTTCTACATTTAATTCGTAAAAAATAA

Protein sequence :
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSI
EDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
folA-2 YP_189146.1 dihydrofolate reductase Not tested ¥ÕSP¥â Protein 3e-63 80