Gene Information

Name : leuS (SACOL1808)
Accession : YP_186641.1
Strain : Staphylococcus aureus COL
Genome accession: NC_002951
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 1862816 - 1865233 bp
Length : 2418 bp
Strand : -
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
GTGTTGAATTACAACCACAATCAAATTGAAAAGAAATGGCAAGACTATTGGGACGAAAATAAAACATTTAAAACAAATGA
TAACTTAGGTCAAAAGAAATTTTATGCTTTAGACATGTTTCCATATCCATCAGGTGCTGGTTTACATGTTGGACATCCTG
AGGGCTATACAGCAACAGATATCATTTCAAGATATAAAAGAATGCAAGGATATAATGTATTACATCCGATGGGGTGGGAT
GCATTCGGATTACCAGCAGAGCAATATGCTTTAGACACTGGCAACGACCCACGTGAATTTACAAAGAAAAATATCCAAAC
TTTTAAACGACAAATTAAAGAATTAGGGTTCAGTTATGATTGGGATCGTGAAGTTAATACAACAGATCCAGAATACTATA
AATGGACACAGTGGATTTTCATACAGTTATATAACAAAGGTTTAGCATACGTTGATGAAGTTGCAGTTAACTGGTGTCCA
GCATTAGGCACTGTTTTATCTAACGAAGAAGTGATTGATGGTGTCTCTGAACGTGGTGGACATCCAGTTTATCGTAAGCC
GATGAAACAATGGGTACTTAAAATCACAGAATATGCAGATCAATTATTAGCAGATTTAGATGATTTAGATTGGCCTGAGT
CTTTAAAAGATATGCAGCGCAATTGGATTGGACGTTCTGAAGGGGCCAAAGTTTCATTTGATGTAGATAATACGGAAGGA
AAAGTAGAAGTATTTACGACTAGACCAGATACAATCTATGGTGCATCATTCTTAGTCTTAAGTCCTGAACATGCATTAGT
TAATTCAATTACAACAGATGAATATAAAGAAAAAGTAAAAGCTTATCAAACAGAAGCTTCTAAAAAGTCAGATTTAGAAC
GTACAGATTTAGCAAAAGATAAATCAGGTGTATTTACTGGTGCATATGCAACTAATCCTTTATCTGGTGAAAAAGTACAA
ATTTGGATTGCTGATTATGTATTATCAACATATGGTACTGGAGCAATTATGGCAGTACCAGCGCATGATGACAGAGATTA
TGAATTTGCTAAAAAGTTTGATTTGCCAATCATTGAAGTCATCGAAGGTGGAAATGTTGAAGAAGCAGCATACACTGGTG
AAGGTAAACATATTAATTCTGGTGAACTTGATGGTTTAGAAAATGAAGCGGCAATTACTAAAGCTATTCAATTATTAGAG
CAAAAAGGTGCTGGCGAAAAGAAAGTTAATTACAAATTAAGAGATTGGTTATTCAGTCGTCAGCGTTATTGGGGCGAACC
AATTCCTGTCATTCATTGGGAAGATGGAACAATGACAACTGTTCCTGAAGAAGAGCTACCATTGTTGTTACCTGAAACAG
ATGAAATCAAGCCATCAGGGACTGGTGAGTCTCCACTAGCTAATATTGATTCATTTGTAAATGTTGTAGATGAAAAAACA
GGTATGAAAGGACGTCGTGAAACAAATACAATGCCACAATGGGCAGGTAGTTGTTGGTATTATTTACGTTACATCGATCC
TAAAAATGAAAATATGTTAGCAGATCCTGAAAAATTAAAACATTGGTTACCTGTTGATTTATATATCGGTGGAGTAGAAC
ATGCGGTTCTTCACTTATTATATGCAAGATTTTGGCATAAAGTCCTTTATGATTTGGCTATCGTACCTACTAAAGAACCT
TTCCAAAAATTATTTAACCAAGGTATGATTTTAGGAGAAGGTAATGAGAAGATGAGTAAATCTAAAGGAAATGTAATCAA
TCCTGATGATATAGTACAGTCTCATGGTGCAGATACTTTGCGTCTTTACGAAATGTTTATGGGACCTTTAGATGCTGCAA
TTGCATGGAGTGAAAAAGGATTAGATGGGTCTCGTCGATTCTTAGATCGCGTATGGCGTTTAATGGTAAATGAAGATGGG
ACATTGAGTTCAAAAATTGTAACTACAAATAATAAATCTTTAGATAAAGTTTATAACCAAACTGTTAAAAAGGTAACAGA
AGACTTTGAAACATTAGGATTTAATACTGCTATTAGTCAATTAATGGTATTTATTAATGAGTGTTATAAAGTTGATGAAG
TTTATAAACCTTACATTGAAGGCTTCGTTAAAATGTTAGCACCTATTGCACCACATATCGGTGAAGAATTATGGTCAAAA
TTAGGACATGAAGAGTCTATTACGTACCAACCTTGGCCAACTTATGACGAAGCACTACTTGTAGATGATGAAGTAGAAAT
CGTTGTTCAAGTGAATGGTAAATTGAGAGCTAAAATTAAAATTGCTAAAGATACATCAAAAGAAGAAATGCAAGAAATTG
CCTTATCTAATGACAATGTTAAAGCGAGTATTGAAGGTAAAGACATCATGAAAGTCATCGCTGTTCCTCAAAAATTAGTC
AATATTGTAGCTAAATAA

Protein sequence :
MLNYNHNQIEKKWQDYWDENKTFKTNDNLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIISRYKRMQGYNVLHPMGWD
AFGLPAEQYALDTGNDPREFTKKNIQTFKRQIKELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCP
ALGTVLSNEEVIDGVSERGGHPVYRKPMKQWVLKITEYADQLLADLDDLDWPESLKDMQRNWIGRSEGAKVSFDVDNTEG
KVEVFTTRPDTIYGASFLVLSPEHALVNSITTDEYKEKVKAYQTEASKKSDLERTDLAKDKSGVFTGAYATNPLSGEKVQ
IWIADYVLSTYGTGAIMAVPAHDDRDYEFAKKFDLPIIEVIEGGNVEEAAYTGEGKHINSGELDGLENEAAITKAIQLLE
QKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLLLPETDEIKPSGTGESPLANIDSFVNVVDEKT
GMKGRRETNTMPQWAGSCWYYLRYIDPKNENMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLYDLAIVPTKEP
FQKLFNQGMILGEGNEKMSKSKGNVINPDDIVQSHGADTLRLYEMFMGPLDAAIAWSEKGLDGSRRFLDRVWRLMVNEDG
TLSSKIVTTNNKSLDKVYNQTVKKVTEDFETLGFNTAISQLMVFINECYKVDEVYKPYIEGFVKMLAPIAPHIGEELWSK
LGHEESITYQPWPTYDEALLVDDEVEIVVQVNGKLRAKIKIAKDTSKEEMQEIALSNDNVKASIEGKDIMKVIAVPQKLV
NIVAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 0.0 66