Gene Information

Name : megL (PG0343)
Accession : NP_904655.1
Strain : Porphyromonas gingivalis W83
Genome accession: NC_002950
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 377271 - 378452 bp
Length : 1182 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence :
ATGCGTAGTGGCTTTGCCACACGTGCCATCCATGGAGGCGCTATCGAGAACGCCTTCGGCTGCTTAGCCACTCCCATTTA
CCAAACATCGACTTTCGTTTTTGACACTGCCGAACAGGGAGGCCGCCGCTTTGCCGGAGAGGAAGACGGATACATCTATA
CCCGTCTGGGCAACCCCAACTGCACCCAAGTGGAAGAGAAACTGGCCATGCTCGAAGGCGGAGAAGCCGCCGCATCGGCC
TCATCCGGTATCGGAGCCATCAGCTCTGCCATCTGGGTATGCGTGAAGGCCGGCGACCATATCGTAGCCGGCAAGACGCT
CTACGGCTGCACCTTCGCCTTCCTCACCCACGGACTGAGCCGCTACGGTGTGGAAGTCACCCTCGTGGATACCCGCCATC
CGGAAGAGGTGGAGGCCGCCATTCGCCCGAATACGAAGCTCGTCTATCTGGAGACTCCGGCCAACCCCAATATGTACCTG
ACCGACATCAAGGCAGTCTGCGACATCGCTCATAAGCACGAAGGCGTACGCGTCATGGTGGACAATACCTACTGCACGCC
CTATATCTGCCGTCCGCTGGAGCTGGGTGCCGACATCGTGGTACACAGCGCGACCAAGTACCTGAACGGACATGGCGACG
TCATCGCCGGATTCGTCGTAGGTAAAGAGGACTACATCAAGGAGGTGAAGCTCGTCGGCGTCAAGGACCTCACGGGGGCC
AATATGAGTCCGTTCGATGCTTATCTGATCAGCCGCGGCATGAAGACGCTGCAGATACGTATGGAGCAGCACTGCCGCAA
TGCTCAGACCGTAGCCGAATTTCTCGAAAAGCATCCGGCCGTAGAAGCAGTTTATTTCCCCGGACTTCCGAGCTTCCCCC
AATACGAATTGGCCAAGAAGCAGATGGCACTGCCCGGAGCCATGATCGCCTTCGAAGTGAAGGGCGGTTGCGAAGCCGGT
AAGAAGCTGATGAACAACCTGCACCTCTGCTCCCTCGCCGTGAGCTTGGGCGATACGGAAACCCTCATCCAGCATCCGGC
CAGCATGACCCACTCGCCCTACACACCCGAAGAGCGTGCTGCCAGCGACATATCCGAAGGACTGGTACGCCTGTCCGTGG
GTCTGGAGAACGTGGAGGACATCATCGCCGACCTCAAGCACGGTCTGGACAGCCTGATCTAA

Protein sequence :
MRSGFATRAIHGGAIENAFGCLATPIYQTSTFVFDTAEQGGRRFAGEEDGYIYTRLGNPNCTQVEEKLAMLEGGEAAASA
SSGIGAISSAIWVCVKAGDHIVAGKTLYGCTFAFLTHGLSRYGVEVTLVDTRHPEEVEAAIRPNTKLVYLETPANPNMYL
TDIKAVCDIAHKHEGVRVMVDNTYCTPYICRPLELGADIVVHSATKYLNGHGDVIAGFVVGKEDYIKEVKLVGVKDLTGA
NMSPFDAYLISRGMKTLQIRMEQHCRNAQTVAEFLEKHPAVEAVYFPGLPSFPQYELAKKQMALPGAMIAFEVKGGCEAG
KKLMNNLHLCSLAVSLGDTETLIQHPASMTHSPYTPEERAASDISEGLVRLSVGLENVEDIIADLKHGLDSLI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-63 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-64 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL NP_904655.1 methionine gamma-lyase BAC0207 Protein 3e-102 57