Gene Information

Name : lysS (PG1370)
Accession : NP_905535.1
Strain : Porphyromonas gingivalis W83
Genome accession: NC_002950
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 1450583 - 1452319 bp
Length : 1737 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGAACATACTCGAACTTTCGGAACAAGAAGTCGTACGCCGTAACAGCTTAGAGCAACTGCGTAATTTGGGGATCGATCC
ATATCCTGCAGCGGAATATACCGTCAATGCCTATTCCGCCGAGATCAAAAGGAATTTCAATGGCGATGAGAATGTCGCCA
AACGTCAAGTAAGCATTGCCGGACGTATTATGAGCCGCCGTATCATGGGGAAAGCTACATTCATGGAGCTGCAAGATGCT
GAGGGGCGTATCCAGATCTATATTACTCGGGACGATATTTGTCCGGGTGAGGATAAGGAGTTCTACAATACGGTGGTCAA
GAAGTGTACGGATATAGGTGATTTTATCGGAGTGAAAGGGTACGTATTCCGCACTCAGATGGGAGAAATATCGGTGCATG
TGCAGGAGATGACTTTCTTGTCGAAAGCTATCCGCCCCCTTCCTGTGGTAAAAGAAAAAGATGGGGAGGTCTTCGATGGC
TTCACGGATCCGGAGCAGCGTTATCGTCAGCGATACGTGGATCTGGTCGTCAATAGTCATGTCAAAGACATTTTCCTCAA
GCGTACGATGGTATTCAATTCGATGCGCAGTTTCTTCAATGAGTGCGGATACATCGAAGTGGATACACCTGTACTCCAAT
CGATCCCGGGAGGTGCAGCTGCGCGTCCTTTTATCACGCATCATAACGCTCTGGACATTCCGCTCTATCTGAGAATCGCT
AACGAATTGTATCTGAAGCGTCTGATCGTGGGCGGTTTCGATGGTGTGTATGAATTCAGCCGCAATTTCCGAAATGAGGG
GATGGACCGCACGCATAATCCTGAGTTCACGGCCATGGAGATCTATGTGGCGTATAAGGATTACAACTGGATGATGAACT
TTACGGAGCAGATGCTCGAACGCATCTGTATGGATGTGCTGGGTACTACTCAGATGAAGGTGGGCGGGAAATTGATCGAC
TTCAAGGCCCCCTACAAGCGAGTGACCATGATCGAAGCCATCCATGAGCATACGGGTATCGACATCAGCGGAATGAACGA
GGCCGAGCTGCGTCAGGTATGCGACAAGCTGGGCGTAGAGCACAATGAAACGATGGGCAAAGGCAAGCTCATCGATGAGA
TCTTCGGCGAGAAGTGCGAGAAGAACTATATCCAGCCTACTTTCATCACAGACTATCCGAAAGAAATGTCGCCTCTGACG
AAGGAGCACCGCACCAATCCGGAGCTGACAGAGCGATTCGAGCTGATGGTCAATGGCAAGGAGTTGGCCAACGCCTACTC
GGAGCTGAACGACCCGATTGATCAGAGAGAACGTTTCGAAGAACAACTCAAGCTGTCCGAGAAAGGCGATGACGAAGCCA
TGTACATCGACAACGACTTCATCCGTGCCCTTGAATACGGTATGCCGCCGACCAGCGGTATGGGTATCGGTATGGACCGT
TTGGTCATGCTATTGACAGGGCAGGAGAGTATTCAGGAGGTGCTCCTCTTCCCACAGATGAAGCCCGAGAAGGTGGCTCC
ACGAGATACGAAAGAGAAGTTCGCCGTTTGTGGCGTTCCCGAAGAGTGGGTACCTGTACTGCATAAGGCCGGCTATCTTA
CCGTACAGTCGATGCGAGAGGATAAACCGGGCAAGGTGATGCAGCAGCTGATGGACATCAATAAGAAATATAAGTTGGGG
CTTGCCGGTTTGAATCTGGAAACCGTTTCGGCTTGGCAGGAAGCCCCATATGAGTAA

Protein sequence :
MNILELSEQEVVRRNSLEQLRNLGIDPYPAAEYTVNAYSAEIKRNFNGDENVAKRQVSIAGRIMSRRIMGKATFMELQDA
EGRIQIYITRDDICPGEDKEFYNTVVKKCTDIGDFIGVKGYVFRTQMGEISVHVQEMTFLSKAIRPLPVVKEKDGEVFDG
FTDPEQRYRQRYVDLVVNSHVKDIFLKRTMVFNSMRSFFNECGYIEVDTPVLQSIPGGAAARPFITHHNALDIPLYLRIA
NELYLKRLIVGGFDGVYEFSRNFRNEGMDRTHNPEFTAMEIYVAYKDYNWMMNFTEQMLERICMDVLGTTQMKVGGKLID
FKAPYKRVTMIEAIHEHTGIDISGMNEAELRQVCDKLGVEHNETMGKGKLIDEIFGEKCEKNYIQPTFITDYPKEMSPLT
KEHRTNPELTERFELMVNGKELANAYSELNDPIDQRERFEEQLKLSEKGDDEAMYIDNDFIRALEYGMPPTSGMGIGMDR
LVMLLTGQESIQEVLLFPQMKPEKVAPRDTKEKFAVCGVPEEWVPVLHKAGYLTVQSMREDKPGKVMQQLMDINKKYKLG
LAGLNLETVSAWQEAPYE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 2e-106 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS NP_905535.1 lysyl-tRNA synthetase VFG1668 Protein 9e-107 46