Gene Information

Name : guaA (PP_1032)
Accession : NP_743193.1
Strain : Pseudomonas putida KT2440
Genome accession: NC_002947
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1177116 - 1178693 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCCCTCGACATTCACGCTCACCGCATCCTGATCCTCGATTTCGGTTCCCAGTACACCCAGCTGATCGCCCGCCGCGT
GCGCGAAATCGGCGTGTACTGCGAACTGCACCCGTTCGACATGGACGATGAAGCGATCCGCGAATTCAACCCGCGCGGCA
TCATCCTCGCCGGCGGCCCCGAGTCGGTCCACGAAGCCAACAGCCCGCGCGCTCCGCAGGCCGTGTTTGACCTGAATGTG
CCTGTGCTGGGTATCTGCTACGGCATGCAGACCATGGCCGAGCAGATGGGCGGCAAGGTAGAAGGTTCCGACCTGCGTGA
GTTCGGCTATGCCCGTGTGGACGTTGTCGGCAAGAGCCGCCTGCTCGACGGCATCGAAGACCACGTTGATGACGACGGCG
TGCTGGGCCTGGACGTGTGGATGAGCCACGGTGACAAGGTCACCCAGATGCCTGGCAACTTCAACATTCTGGCCAGCACC
CCAAGCTGCCCGATCGCCGGCATGTACGACGACGTCCGCGGCTACTACGGCGTGCAGTTCCACCCCGAAGTGACCCACAC
CAAGCAAGGTGGTCGTATCCTGTCCCGCTTCGTGCAGGACATCTGCGGCTGTGAAGCCCTGTGGACGGCGTCCAACATCG
TCGAAGACGCCATCGCCCAGGTGCGTGCGCAAGTCGGTTCGGCCAACGTTCTGCTGGGCCTGTCCGGCGGCGTTGACAGC
TCGGTGGTTGCCGCGCTGCTGCACCGCGCCATCGGCGACCAGCTGACCTGCGTATTCGTCGACAACGGCCTGCTGCGCCT
GCACGAAGGCGACCAGGTGATGGCCATGTTCAAAGAGAACATGGGCGTCAAGGTGATCCGCGCCGACGCTGAAAAGCAGT
TCCTCGACAACCTGGAAGGCGAAGCGGACCCTGAGAAGAAGCGCAAGATCATCGGCCGCACCTTCATCGACGTGTTCGAT
GCCGAAGCCAGCAAGCTGGAGAACATCCAGTTCCTCGCCCAGGGCACCATCTACCCGGACGTGATCGAGTCGGCTGGCGC
CAAGAGCGGCAAGGCCCACGTGATCAAGTCGCACCACAACGTAGGCGGCCTGCCGGAGGAGATGAACCTCAAGCTGGTCG
AGCCGCTGCGTGAACTGTTCAAGGACGAAGTGCGCAAGATCGGCCTGGAGCTGGGCCTGCCATACGACATGGTCTACCGC
CACCCGTTCCCGGGCCCGGGCCTGGGCGTGCGTATCCTCGGTGAAGTGAAGAAGGAATACGCCGACATCCTGCGTCGCGC
CGACCACATCTTCATCGAAGAGCTGCGCAAGGCCGACTGGTACCACAAGACCAGCCAGGCGTTCGTGGTGTTCCAGCCGG
TCAAGTCGGTCGGCGTCGTCGGCGACGGCCGTCGCTACGCCTGGGTCGTGGCCCTGCGTGCCGTCGAGACCGTGGACTTC
ATGACCGCGCGTTGGGCACACCTGCCGTACGAGCTGCTGGAAACTGTCAGCGGTCGTATCATCAACGAAATCGACGGTAT
CTCGCGCGTTACCTACGACGTGTCGAGCAAGCCGCCTGCCACTATCGAGTGGGAGTGA

Protein sequence :
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFNPRGIILAGGPESVHEANSPRAPQAVFDLNV
PVLGICYGMQTMAEQMGGKVEGSDLREFGYARVDVVGKSRLLDGIEDHVDDDGVLGLDVWMSHGDKVTQMPGNFNILAST
PSCPIAGMYDDVRGYYGVQFHPEVTHTKQGGRILSRFVQDICGCEALWTASNIVEDAIAQVRAQVGSANVLLGLSGGVDS
SVVAALLHRAIGDQLTCVFVDNGLLRLHEGDQVMAMFKENMGVKVIRADAEKQFLDNLEGEADPEKKRKIIGRTFIDVFD
AEASKLENIQFLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRKIGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADILRRADHIFIEELRKADWYHKTSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETVDF
MTARWAHLPYELLETVSGRIINEIDGISRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-127 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-127 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-127 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-110 48