Gene Information

Name : thyA (NGO1357)
Accession : YP_208417.1
Strain : Neisseria gonorrhoeae FA 1090
Genome accession: NC_002946
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1317126 - 1317920 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAGGCCTATTTGGACTTGATGCGCCACGTCCTCGACAACGGTACGGACAAATCAGACCGCACCGGTACGGGTACGCG
CTCCGTATTCGGTTATCAGATGCGTTTTGACTTGGGCAAAGGTTTTCCGCTGCTGACGACCAAAAAGCTGCATTTGCGCT
CGATAATCCACGAGCTGCTTTGGTTCCTCAAAGGCGATACCAATATCAAATACCTGAAGGATAACAATGTTTCCATTTGG
GACGAGTGGGCGGACGAAAACGGCGACTTGGGCCCGGTTTACGGCTACCAATGGCGCAGCTGGCCCGCGCCCGACGGCAG
GCATATCGACCAAATCGCCAATGTGGTGGAACAAATTAAGAAAAACCCCGACTCGCGCCGCCTGATTGTGTCGGCGTGGA
ATCCGGCTTTGGTCGATGAGATGGCCTTGCCGCCCTGCCACGCGCTGTTTCAGTTTTACGTTGCCGACGGCAAACTGTCC
TGCCAGCTTTACCAGCGTAGTGCAGATATTTTCCTTGGTGTGCCGTTTAATATTGCCAGCTACGCGCTGTTGACGATGAT
GATGGCGCAAGTGTGCGGGCTGGAGGCGGGCGAGTTTGTCCATACGTTTGGCGACGCGCATTTGTACCGTAACCATTTCG
AACAGGCCGCATTGCAGTTGGAACGCGAACCGCGCGCCTTGCCTGTGATGAAAATCAATCCTGAAGTCAAGGATTTGTTT
GCCTTCAAGTTTGAAGATTTCGAGTTGGAAGGCTACGATCCGCATCCGCACATCAAGGCGGTAGTGTCGGTTTAG

Protein sequence :
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIW
DEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLS
CQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLF
AFKFEDFELEGYDPHPHIKAVVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-82 64