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Name : leuS (MAP0048) Accession : NP_958982.1 Strain : Mycobacterium avium K-10 Genome accession: NC_002944 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 52505 - 55414 bp Length : 2910 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : GTGACCGAATCCCCGACCACTTCGCCCGCCACCGGCTCCGGTGCCGCCGCGCCGGACTCCGACGCGCCGCCGTATCGCTA CACCGCGGCGCTGGCGGGCCGGATCGAGGGCAGCTGGCAGGACACCTGGGCCAAGCTCGGGACGTTCAACGTGCCCAACC CGGTCGGTTCGTTGGCCCCGACGGACGGGACCCCGGTCCCCGAGGACAAGCTGTTCGTGCAGGACATGTTCCCCTACCCG TCGGGGGAGGGGCTGCACGTCGGCCACCCGCTGGGCTACATCGCCACCGACGTGTACGCCCGCTACTTCCGGATGACCGG CCGTAACGTGTTGCATGCGTTGGGTTTTGACGCTTTCGGCCTGCCCGCCGAGCAATACGCGGTGCAGACCGGCACCCACC CGCGCACCAGGACCGAGGCCAACGTGGTCAACTTCCGCCGCCAGCTGGGCCGGCTGGGGCTGGGCCACGACAGCAGGCGC AGCTTCTCCACCACCGACGTCGAGTTCTACAAGTGGACGCAGTGGATCTTCCTGCAGATCTACAACGCCTGGTTCGACCC CGCCGCCAACAAGGCCCGACCCATCGCCGAGCTGGTCGCCGAATTCGATTCCGGCGCGCGCAGCCTCGACGACGGGCGCA ACTGGTCGGAGTTGTCGGCGGGGGAGCGGGCCGACGTGATCGACAGCCACCGGCTGGTCTACCGTGCGGACTCGATGGTC AACTGGTGTCCCGGACTGGGCACCGTGCTGGCCAACGAGGAGGTCACCGCCGACGGGCGCAGCGACCGCGGCAACTTCCC GGTGTTCCGAAAGCGGTTGCGGCAGTGGATGATGCGGATCACCGCCTACTCCGATCGGCTGCTCGACGACCTCGACCTGC TGGACTGGCCGGAGCCGGTGAAGACCATGCAGCGCAACTGGATCGGCCGTTCCACCGGCGCCAAGGCCCTGTTCGCGGCG ACCGGCGCCGACGGCGCGGCGCTCGACATCGAGGTGTTTACCACCCGACCGGACACGCTGTTCGGCGCCACCTATATGGT GCTGGCCCCCGAGCACGAGCTGGTCGACGAGCTGGTCGCGCCCGCCTGGCCGGACGGCACCGACCCGCGCTGGACATACG GCGCCGCCACTCCGGGCGAGTCGGTCGCCGCCTACCGGCGGGCGATCGCCTCGAAGTCGGACCTCGAGCGCCAGGAGAGC AAGGCCAAAACCGGTGTCTTCCTGGGCAGCTACGCCACCAATCCCACCAATGGCAAGCCGGTTCCGATCTTCATCGCCGA CTACGTGCTGGCCGGATACGGCACCGGCGCGATCATGGCGGTGCCCGGCCACGACCAGCGCGACTGGGACTTCGCGCACG AATTCGGCCTGCCCATCGTGGAAGTCATTGCCGGAGGCGATATTTCGGAGGGCGCCTACGCCGGCGACGGGGTGTTGGTG AACTCCGGCTACCTGGACGGACTGGATGTGGCGGCGGCCAAGGAGGCGATCACCGCCCGGCTGGAAGCCGAAGGCCGTGG CTGCGCGCGGGTCGAATACAAGTTGCGTGACTGGCTTTTCGCCCGGCAACGGTACTGGGGCGAGCCGTTCCCGATCGTCT ACGACAGCGACGGGCGGCCGCATGCCCTCGACGAAGCCGCTCTGCCGGTGGAACTGCCCGACGTGCCGGACTATTCGCCG GTGCTGTTCGACCCCGACGACGCCGACAGCGAACCGTCGCCGCCGTTGGCCAAGGCGACCGACTGGGTGCACGTCGAGCT GGACCTCGGCGACGGCCTGAAGCCCTACAGCCGCGACACCAACGTGATGCCGCAATGGGCCGGCAGCTCCTGGTACGAAC TGCGCTACACCGATCCGCACAACTCGGAACGCTTCTGCGCCAAGGAGAATGAGGCCTACTGGATGGGGCCGCGGCCCGCC GAGCACGGGCCGCAGGATCCCGGCGGCGTCGACCTGTACGTCGGTGGGGCCGAACACGCGGTGTTGCATCTGCTCTACGC CCGGTTCTGGCACAAGGTGCTCTACGACCTGGGCCACGTCAGCTCCCGCGAGCCGTACCGCCGGCTGGTCAACCAGGGCT ACATTCAGGCGTTCGCCTACACCGACTCGCGCGGCTCGTACGTGCCGGCCGAGGAGGTCGTCGAACGCGACGGCCGGTTT TTCTACCGGGGTCCCGACGGGGAGATCGAGGTCTTCCAGGAATTCGGGAAAATCGGGAAGAGCCTGAAGAATTCGATCTC ACCCGACGAGATCTGCGACGACTACGGCGCCGACACGCTGCGGGTCTACGAGATGTCGATGGGTCCGCTGGAGGCGTCCC GTCCCTGGGCGACCAAGGATGTGGTGGGCGCTCACCGGTTCCTGCAGCGGGTGTGGCGACTGGTCGTCGACGAGCAGACG GGCGAGACGCGGGTGGTCGACGGGGCCGGACGGGATCTGCCCACCGGTACCCTGCGGCTGCTGCACCGCACCATTGCCGG AGTCTCGGAAGACTATGCGGCCCTGCGCAATAACACCGCCGTGGCCAAGTTGATCGAGTACACCAACCATCTCACCAAGG AACATCGCGACGCGGTGCCCCGCGCGGCGGTCGAGCCGCTGGTGTTGATGCTGGCGCCGTTGGCGCCGCACATGGCCGAG GAGTTGTGGCTGCGGCTGGGCCACACCACCTCGCTGGCGCACGGCCCGTTCCCGGTGGCGGACCCGGCGTACCTCGTCGA GGACACCGTCGAATACCCGGTGCAGGTGAACGGCAAGGTGCGCGGGAGGGTGACGGTGGCGGCCGACGCCGATCGGGACA CCCTCGAGGCCGCCGCGCTGGCCGACGAGAAGGTGCTGGCGTTCCTGGCCGGCGCCCAGCCGCGCAAGGTGATCGTGGTC CCGGGCCGGCTGGTCAACCTGGTGGTGTAG Protein sequence : MTESPTTSPATGSGAAAPDSDAPPYRYTAALAGRIEGSWQDTWAKLGTFNVPNPVGSLAPTDGTPVPEDKLFVQDMFPYP SGEGLHVGHPLGYIATDVYARYFRMTGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGLGHDSRR SFSTTDVEFYKWTQWIFLQIYNAWFDPAANKARPIAELVAEFDSGARSLDDGRNWSELSAGERADVIDSHRLVYRADSMV NWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYSDRLLDDLDLLDWPEPVKTMQRNWIGRSTGAKALFAA TGADGAALDIEVFTTRPDTLFGATYMVLAPEHELVDELVAPAWPDGTDPRWTYGAATPGESVAAYRRAIASKSDLERQES KAKTGVFLGSYATNPTNGKPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFAHEFGLPIVEVIAGGDISEGAYAGDGVLV NSGYLDGLDVAAAKEAITARLEAEGRGCARVEYKLRDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSP VLFDPDDADSEPSPPLAKATDWVHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAYWMGPRPA EHGPQDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRRLVNQGYIQAFAYTDSRGSYVPAEEVVERDGRF FYRGPDGEIEVFQEFGKIGKSLKNSISPDEICDDYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRLVVDEQT GETRVVDGAGRDLPTGTLRLLHRTIAGVSEDYAALRNNTAVAKLIEYTNHLTKEHRDAVPRAAVEPLVLMLAPLAPHMAE ELWLRLGHTTSLAHGPFPVADPAYLVEDTVEYPVQVNGKVRGRVTVAADADRDTLEAAALADEKVLAFLAGAQPRKVIVV PGRLVNLVV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 4e-149 | 49 |
