Gene Information

Name : guaA (MAP3489c)
Accession : NP_962423.1
Strain : Mycobacterium avium K-10
Genome accession: NC_002944
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3878538 - 3880115 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGCCGAATCCCCCCCCACCGAGGTGCCCGAACCGCCCGCTCGACCCGTGTTGGTGGTCGACTTCGGTGCCCAGTACGC
GCAGCTGATCGCCCGGCGGGTGCGTGAGGCGCGGGTCTTCTCCGAGGTCATTCCACACACCGCGACGATCGAGGAGATCA
AGGCCCGCCAGCCGCGGGCGCTGGTGCTCTCCGGCGGCCCGTCCAGCGTCTACGAGCCGGGCGCCCCGCAGCTGGATCCG
GCGGTGTTCGACCTGGGGGTGCCGGTGTTCGGCATCTGCTACGGATTTCAGGCCATGGCGCAGGCTTTGGGCGGCACCGT
CGCGCACACCGGCACCAGCGAATACGGTCGCACCGAGCTGAAAGTGCTTGGCGGCGAACTGCATTCGGGGCTGCCGGGCG
TGCAGCCGGTCTGGATGAGCCACGGTGATGCGGTCACCGCCGCGCCGGACGGTTTCGAGGTGGTGGCCAGCAGCCCCGGC
GCCGTGGTGGCCGCGTTCGAGAACCGGGCCCGCCGCCTGGCCGGGGTGCAGTACCACCCGGAGGTGATGCACACCCCGCA
TGGCCAGCAGGTGCTGAGCCGGTTCCTGCACGACTTCGCCGGGCTGGGCGCGGACTGGACGGCCGCCAACATCGCCGGTG
TGCTGGTGGAGCAGGTCCGCGCGCAGATCGGCGACGGCCATGCGATCTGCGGATTGTCCGGCGGGGTGGATTCCGCGGTG
GCCGCCGCCCTGGTGCAGCGCGCCATCGGCGATCGCTTGACGTGTGTGTTCGTCGACCACGGGTTGTTGCGTGCCGGTGA
ACGCGCGCAGGTGCAGCGCGATTTCGTGGCCGCCACCGGCGCCAACCTGGTCACCGTCGACGCGGCGGACACCTTCCTGC
AGGCGCTGGCCGGGGTGACCAACCCGGAGGGCAAGCGCAAGATCATCGGCCGGCAGTTCATCCGGGCGTTCGAGGGCGCG
GTGCGAGATGTGTTGGGGGACAAGCCGGTCGAGTTCCTGGTGCAGGGCACGCTGTATCCCGACGTGGTGGAGTCCGGCGG
GGGCAGCGGCACCGCGAACATCAAGAGCCACCACAACGTCGGGGGGCTGCCCGGCGACCTGAAGTTCACCCTCGTCGAGC
CGCTGCGGCTGCTGTTCAAGGACGAGGTGCGCGCGGTCGGCCGGGAACTGGGGCTGCCGGAGGAAATCGTTGCGCGCCAA
CCCTTTCCGGGTCCCGGCCTGGGCATCCGGATCGTCGGCGAGGTCACCGCGACGCGGCTGGACACGCTGCGGCGGGCGGA
CTCGATCGCGCGCGAGGAACTCACCGCCGCCGGCTTGGACTCGCTGATCTGGCAGTGCCCGGTGGTGCTGCTCGGTGAGG
TCCGCTCGGTGGGGGTGCAGGGCGACAACCGCACCTACGGGCATCCGATCGTGCTGCGGCCGGTGACCAGTGAGGACGCC
ATGACCGCGGACTGGACCCGGGTCCCCTACGAGGTGCTGGAGCGGATCTCGACCCGGATCACCAACGAGGTCCCCGAGGT
CAACCGCGTGGTGCTGGACATCACCAGCAAGCCGCCCGGCACCATCGAGTGGGAGTAG

Protein sequence :
MAESPPTEVPEPPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTATIEEIKARQPRALVLSGGPSSVYEPGAPQLDP
AVFDLGVPVFGICYGFQAMAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAAPDGFEVVASSPG
AVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAV
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVTNPEGKRKIIGRQFIRAFEGA
VRDVLGDKPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQ
PFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSLIWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDA
MTADWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 78
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-132 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-132 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-132 52