Gene Information

Name : thyA (MAP2869c)
Accession : NP_961803.1
Strain : Mycobacterium avium K-10
Genome accession: NC_002944
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3196231 - 3197031 bp
Length : 801 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
GTGCCCATCCCGACGCCCTACGAGGACCTTCTGCGTCTGGTGCTCGATCGGGGAACGGCCAAATCCGACCGAACCGGCAC
CGGGACGCGCAGCCTGTTCGGCCAGCAGCTGCGCTATGACCTGTCGGCCGGCTTCCCGCTGATCACCACCAAGAAGGTGC
ATCTGAAATCGGTGGTCTATGAGTTGCTGTGGTTCTTGCGCGGCGACTCCAACGTCGACTGGCTGCACCGGCACGGCGTC
ACCATTTGGGACGAATGGGCAAGCGACACAGGCGATCTCGGACCGATCTACGGCGTGCAGTGGCGGTCCTGGCCGACGCC
GTCGGGTGAGCACATCGACCAGATCAGCGCCGCGCTGGATCTGTTGCGCACCGACCCCGACTCGCGGCGCATCATCGTGT
CGGCGTGGAACGTCGGCGAGATCCCGCGGATGGCGCTGCCGCCGTGTCACGCGTTCTTCCAGTTCTACGTGGCCGACGGG
CGGCTGAGCTGCCAGCTCTACCAGCGCAGCGCCGACCTGTTTCTGGGCGTGCCGTTCAACATCGCCAGCTACGCCCTGCT
CACCCACATGATGGCCGCCCAGGCCGGGCTGTCGGTCGGCGAATTCGTGTGGACCGGTGGCGACTGCCACATCTACGACA
ACCACGTCGAGCAGGTCCGGCTGCAGCTGAGCCGCGAGCCCCGGCCCTACCCGGAACTCATTCTGGCGCATAGGGATTCG
ATCTTCGACTACACCTACGACGACGTCGTGGTGCACAACTACGATCCGCACCCGGCCATCAAGGCCCCCGTCGCGGTATG
A

Protein sequence :
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGV
TIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADG
RLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDS
IFDYTYDDVVVHNYDPHPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-96 72