Gene Information

Name : tpx (MAP1653)
Accession : NP_960587.1
Strain : Mycobacterium avium K-10
Genome accession: NC_002944
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 1806429 - 1806923 bp
Length : 495 bp
Strand : +
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGGCACAGATAACGTTGCGTGGAAACCCGATCAACACCGTCGGCGAGCTGCCCTCCGTCGGCTCCAAGGCCCCGGCCTT
CAGCCTGACGGGCGGCGACCTGAGCCCGGTCACCAGTGATCAATTCAGCGGTAAGCCGTTGGTGCTCAACATCATTCCGT
CCATCGACACGCCGGTGTGCGCGACCAGCGTGCGCACCTTCAACGAGCGGGCGGCCGGCGCCGGCGCCACCGTGCTGAAC
GTGTCCAAGGACCTGCCGTTCGCGCAGGCGCGATTCTGCGGCGCCGAGGGCATCGAGAACGTCAAGACCGCGTCGGCCTT
CCGGGACAGCTTCGGCGACGACTACGGGGTCACCATCGCCGACGGGCCGATGGCCGGGCTGCTGGCCCGGGCCATCGTGG
TGGTCGGCGCCGACGGCAACGTCGCCTACACCGAGCTGGTACCCGAGATCGCCCAGGAGCCCAACTACGACGCGGCGCTG
GCCGCGGCGGGCTAG

Protein sequence : 
MAQITLRGNPINTVGELPSVGSKAPAFSLTGGDLSPVTSDQFSGKPLVLNIIPSIDTPVCATSVRTFNERAAGAGATVLN
VSKDLPFAQARFCGAEGIENVKTASAFRDSFGDDYGVTIADGPMAGLLARAIVVVGADGNVAYTELVPEIAQEPNYDAAL
AAAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 2e-32 43
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-32 43
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 1e-32 43
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 1e-32 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx NP_960587.1 thiol peroxidase VFG0087 Protein 6e-33 43