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Name : lysS (MAP1351c) Accession : NP_960285.1 Strain : Mycobacterium avium K-10 Genome accession: NC_002944 Putative virulence/resistance : Unknown Product : lysyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG1190 EC number : 6.1.1.6 Position : 1450749 - 1454282 bp Length : 3534 bp Strand : - Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA DNA sequence : TTGCGCCGGGCTGGTCGCAGCCGTCAGTTTAGCAGTGTTGAGGAGGCTTTTAGCACTTCGGCCGCCCGACCGGGCCCGCG CGGGCGTCGATCCGGCCGGGAAAACACCGCGAAATTCGTGCCGGCCACTCTTAGCGCTTCGACAAGCTTTTCACGGATAG AGGGCATATCCTCGCGGTCTGTGACACTCGCATCTCCTGGTTCGAGGTCTGGTTCGGGTCCTCGTTCGGGGCCGCGGTTG GGGCCTCGCAACCGGTCGACCTCGCGGTATCGCTGGGTGCCGGCGGCCGCCGGGTGGACCGTGGGTGTGATCGCCACGGT GTCGCTGCTGGGCAGCGTGTCCCCGCTGATCCGGTACCTGATCAAGGTCCCGCGCGAGTTCATCAACGACTACCTGTTCA ACTTCCCCGACACAAGCATCGCCTGGTCGTTCGTGCTGGCCCTGCTGGCGGCGGCGCTGACGGCACGCAAGCGGATCGCC TGGCTGCTGTTGCTGGGCAACATGATCCTGGCCGCCGCCCTCAACGTCGCCGACATCGCCGCCGGTGACAACACCGCCGC CGAGATCTTCGGCGAGAACCTGGGTTTCGCCGTCCACATCGTCGCGATCGTCCTGCTGGTGCTGGCGTATCGGGAGTTCT GGGCCAAGGTCCGCAAGGGCGCGCTGGTCAAGGCGGCCGCGGTGCTGGTCGCCGGGGACGTGGTGGGCATCCTGGTGTCC TGGGGCCTGGTCGAGTTGTTCCCCGGCACCCTGGCCCGCCAGGACCGGCTGCCCTACGTGGTCAACCGGGTGGTCGGCTT CGCGCTAGCCGACCCGGACCTTTTCACCGGCCGCCCGCACGTGTTCCTCAACGCGATCTTCGGGTTGTTCGGCGCGCTCG CGCTGATCATGGCGACCATCGTGCTCTTTCAATCCCAGCGCGCGGAGAACGCGCTGACCGGTGAGGACGAGTCGGCCATC CGCGGACTGCTGGAGTTGTACGGCAAGAACGACTCGCTGGGCTACTTCGCCACCCGCCGCGACAAATCGGTGGTCTTCGC CCAGAGCGGACGCGCCGCCATCACCTACCGGGTCGAGATCGGGGTCTGTTTGGCCAGCGGCGACCCGATCGGCGATCCCC GCGCGTGGCCGCAGGCGGTCGACGCCTGGCTGGGCCTGTGCCAGACCTACGGCTGGGCGCCCGGCGTGATGGGCGCCAGC ACGCAGGGGGCTCGGACCTATCGCGAGGCCGGCCTCAACGCGCTCGAGCTGGGTGACGAGGCCATCCTGCGCACCTCCGA GTTCAAGCTGTCCGGCCCGGACATGCGCGGCGTCCGCCAGGCGGTGACCCGGGCCCGCCGGGCCGGGTTGACGGTGCGGA TCCGCCGGCACCGCGACATCTCCCCCGAGGCGATGGCCGACACCATCGCCCGCGCCGACGCCTGGCGTGACACCCAGACC GAGCGCGGCTTCTCCATGGCGCTGGGCCGGCTCGGTGACCCGGCCGACGGGGACTGCCTGCTGGTGGAGGCCATCGACCG GGACGGCAGCGTGGTCGCGATGCTGTCGCTGGTCCCGTGGGGCACCACCGGTGTGTCGCTGGACTTGATGCGCCGGTCGC CGAGCTCACCCAACGGCACCATCGAGCTGATGGTCAGCGAGCTGGCGTTGAACGCCGAAAGCCTTGGTATCACCCGCATT TCGCTGAACTTCGCGATGTTTCGGTCGGCGTTCGAACAGGGCGCCCAGCTGGGCGCCGGCCCGGTCGCGCGGCTGTGGCG GGGGTTGCTGCTGTTCTTCTCCCGGTGGTGGCAGCTGGAGACCCTGTACCGCTCGAACATGAAGTACCAACCCGATTGGG TTCCGCGCTACGCCTGCTACGAGGATGCCCGGCTGATCCCCCGGGTCGGCGTCGCGTCGGTGATCGCCGAGGGCTTCCTG GTGTTGCCGTTCAGCCGGCGCGACAAGGTGCACACCGGCCATCACCCCGCCGTGCCGGCCCGGCTGGCGCAGTCGGGCCT GCTGCACCACGACGGCTCGGCACCGGACGTGAGCGGGCTGCGCCCGGAGCGCACCGACGCCGAGGAGGCGCGCTCGCGGC TGCCCGAGCAGGTCCGGGTGCGCCTGGCCAAGCTGAAGGTGTTGCAGCGCAACGGTGTTGACGCCTATCCGGTGGGCTGT CCGCCCAGCCACACCGTCGCGCAGGCGCTGGACGCCGACGACCAGCAGGACATCACCGTCGCCGGGCGGATCCTGCGGAT CCGCGACTTCGGTGGTGTGCTGTTCGCCCAGCTGCGGGACTGGTCGGGGGAAATGCAAGTGCTGCTGGACAATTCGCGTC TGGAGCGGGGCCGCACGGCCGACTTCACCGCGGCCATCGATCTCGGCGACCTGGTCGAGGTGTCCGGTCAGATGGGGTTC TCCAAGAAAGGCACCCGGTCGCTGATCGTCACCGACTGGCGGATGATCGGTAAGTGCTTGCGGCCATTGCCGAATAAGTG GAAGGGGCTCACCGATCCGGAGGCCCGGGTGCGAACCCGCTACGTCGACCTGGCGGTCAACCCCGAGTCGCGGGAGTTGA TCGCGGCGCGCAGCGAGGTGCTGCGCTCGGTCCGGCAGACCCTGTTCGCCAAGGGATTCATCGAGGTCGAGACCCCGATC CTGCAGCAGATCCACGGCGGCGCCACCGCCCGGCCGTTCGTCACGCACATCAACACCTACGACATGGACCTGTTCCTGCG CATCGCGCCGGAGCTGTATCTGAAGCGGCTGTGCGTCGGCGGCGTGGAGCGCGTCTTCGAGTTGGGCCGGGCGTTCCGCA ACGAGGGGGTCGACTTCAGCCACAACCCGGAGTTCACCCTGCTGGAGGCCTACCAGGCGCACGCCGACTATCGGGTGTGG ATCGACGGGTGCCGCGAGCTGATCCAGAACGCCGCCCAGGCCGCGCACGGCGAGCAGACCGTGCTGCGGCCCGGCGCCGA CGGCCGGCTGCAACCGGTCGACATCTCCGGGATCTGGGCGGTCAAGACCGTGCACGACGCGGTGTCCGAGGCACTCGGCG AGCAGGTCGACCCCGGCACGTCGCTGTCCACCCTGCGCAAACTGTCCGACGCGGCGCGCATCCCCTACCGCGCGCACTGG GACGCCGGCGCGGTGGTGCTCGAGCTCTACGAGCACCTGGTCGAGGACCGGACCGAGGAGCCGACGTTCTACGTCGACTT CCCCACCTCGGTGTCGCCGCTGACCCGGCCGCACCGCAGCCGGCCCGGGGTCGCGGAGCGGTGGGACCTGGTGGCCTGGG GTGTCGAGCTGGCCACCGCCTACAGCGAGCTGACCGATCCGGTGGAGCAGCGCCGCCGCCTGCAGGAGCAGTCGCTGTTA GCTGCCGGCGGGGATCCCGAGGCGATGGAACTCGACGAGGACTTCCTGCAGGCGATGGAGTACGCGATGCCGCCGACGGG CGGGCTGGGCATGGGCGTCGATCGCCTCGTCATGCTCATAACGGGCCGCAGCATCCGCGAAACCTTGCCGTTTCCGCTGG CCAAGCCGCACTAG Protein sequence : MRRAGRSRQFSSVEEAFSTSAARPGPRGRRSGRENTAKFVPATLSASTSFSRIEGISSRSVTLASPGSRSGSGPRSGPRL GPRNRSTSRYRWVPAAAGWTVGVIATVSLLGSVSPLIRYLIKVPREFINDYLFNFPDTSIAWSFVLALLAAALTARKRIA WLLLLGNMILAAALNVADIAAGDNTAAEIFGENLGFAVHIVAIVLLVLAYREFWAKVRKGALVKAAAVLVAGDVVGILVS WGLVELFPGTLARQDRLPYVVNRVVGFALADPDLFTGRPHVFLNAIFGLFGALALIMATIVLFQSQRAENALTGEDESAI RGLLELYGKNDSLGYFATRRDKSVVFAQSGRAAITYRVEIGVCLASGDPIGDPRAWPQAVDAWLGLCQTYGWAPGVMGAS TQGARTYREAGLNALELGDEAILRTSEFKLSGPDMRGVRQAVTRARRAGLTVRIRRHRDISPEAMADTIARADAWRDTQT ERGFSMALGRLGDPADGDCLLVEAIDRDGSVVAMLSLVPWGTTGVSLDLMRRSPSSPNGTIELMVSELALNAESLGITRI SLNFAMFRSAFEQGAQLGAGPVARLWRGLLLFFSRWWQLETLYRSNMKYQPDWVPRYACYEDARLIPRVGVASVIAEGFL VLPFSRRDKVHTGHHPAVPARLAQSGLLHHDGSAPDVSGLRPERTDAEEARSRLPEQVRVRLAKLKVLQRNGVDAYPVGC PPSHTVAQALDADDQQDITVAGRILRIRDFGGVLFAQLRDWSGEMQVLLDNSRLERGRTADFTAAIDLGDLVEVSGQMGF SKKGTRSLIVTDWRMIGKCLRPLPNKWKGLTDPEARVRTRYVDLAVNPESRELIAARSEVLRSVRQTLFAKGFIEVETPI LQQIHGGATARPFVTHINTYDMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYRVW IDGCRELIQNAAQAAHGEQTVLRPGADGRLQPVDISGIWAVKTVHDAVSEALGEQVDPGTSLSTLRKLSDAARIPYRAHW DAGAVVLELYEHLVEDRTEEPTFYVDFPTSVSPLTRPHRSRPGVAERWDLVAWGVELATAYSELTDPVEQRRRLQEQSLL AAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGVDRLVMLITGRSIRETLPFPLAKPH |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| lysS1 | YP_005686365.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 1e-161 | 44 |
| lysS1 | YP_005682181.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-161 | 44 |
| lysS1 | YP_005684273.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 1e-161 | 44 |
| lysX | YP_003784331.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 1e-161 | 44 |
