Gene Information

Name : pykA (MAP1310)
Accession : NP_960244.1
Strain : Mycobacterium avium K-10
Genome accession: NC_002944
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1397456 - 1398874 bp
Length : 1419 bp
Strand : +
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
GTGAGTAGACGCGGGAAGATCGTCTGCACCCTTGGCCCGGCGACCAATTCGGACGAGTTGATTTTGGCGCTGGTCGAGGC
CGGAATGGACGTCGCCCGACTGAACTTCAGCCACGGCGACTACGCCGACCACAAAGCCGCCTACGAACGGGTGCGGGTGG
CCTCCGACGCCACCGGCCGCGCCGTCGGCGTGCTCGCCGATCTGCAGGGCCCCAAGATCCGCCTGGGGCGCTTTGCCACC
GGGCCCACCTACTGGGCCGACGGCGAAACGGTCCGCATCACCGTCGCCGACTGCGAAGGCAGCCACGACCGGGTGTCGAC
CACCTACAAACAACTGGCCCAGGACGCCGCGGTCGGGGACCGGGTCCTGGTCGACGACGGCAAGGTCGGCCTGGTGGTCG
ACGGCATCGAGGGCGACGACGTCATCTGCACCGTGGTCGAGGGCGGCCCGGTCAGCAACAACAAGGGCATCTCGCTGCCG
GGCATGAACGTCTCCGCACCGGCCTTGTCCGACAAGGACATCGAGGACCTCACCTTCGCGCTCGAGCTGGGCGTCGACCT
GGTCGCGCTGTCCTTCGTGCGTTCGCCCTCCGACGTCGAGCTGGTGCACGAGGTGATGGACCGCGTCGGCCGGCGGGTGC
CCGTGATCGCCAAACTGGAAAAGCCGGAGGCCGTCGACAACCTGGAAGCCATCGTGCTGGCCTTCGACGCCATCATGGTG
GCCCGCGGCGACCTCGGTGTCGAACTTCCCCTGGAAGAGGTTCCGCTGGTGCAGAAGCGGGCCATCCAGATGGCCCGGGA
GAACGCCAAACCCGTCATCGTGGCAACCCAGATGCTCGATTCGATGATCGAGAACTCACGGCCGACCCGGGCCGAGGCCT
CCGACGTCGCCAACGCCGTGCTGGACGGCGCCGACGCCGTGATGCTGTCCGGGGAGACCTCGGTGGGCAAGTACCCGCTG
GCGGCCGTGCGGACCATGGCGCGCATCATCTGCGCGGTCGAGGACAACTCCACGGCCGCCCCGCCGCTCACCCACGTGCC
CCGCACCAAACGCGGGGTGATCTCGTATGCGGCCCGCGACATCGGCGAACGCCTGGACGCCAAGGCGCTGGTCGCGTTCA
CCCAGTCCGGCGACACCGTCAAGCGGCTGGCGCGGTTGCACACCCCGCTGCCGCTGCTGGCCTTCACGGCATGGCCGGAG
GTGCGCAGCCAGCTGGCCATGACCTGGGGCACCGAGACGTTCATCGTGCCGATGATGACCTCCACCGACGGCATGATCCG
CCAGGTGGACAAGTCGCTGCTGGAACTCGGTCGGTACCGGCGTGGTGACCTGGTGGTGATCGTCGCCGGCGCGCCACCTG
GCACAGTAGGGTCAACCAACCTGATCCACGTGCACCGGATCGGGGAGGACGACGTCTAG

Protein sequence :
MSRRGKIVCTLGPATNSDELILALVEAGMDVARLNFSHGDYADHKAAYERVRVASDATGRAVGVLADLQGPKIRLGRFAT
GPTYWADGETVRITVADCEGSHDRVSTTYKQLAQDAAVGDRVLVDDGKVGLVVDGIEGDDVICTVVEGGPVSNNKGISLP
GMNVSAPALSDKDIEDLTFALELGVDLVALSFVRSPSDVELVHEVMDRVGRRVPVIAKLEKPEAVDNLEAIVLAFDAIMV
ARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADAVMLSGETSVGKYPL
AAVRTMARIICAVEDNSTAAPPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVKRLARLHTPLPLLAFTAWPE
VRSQLAMTWGTETFIVPMMTSTDGMIRQVDKSLLELGRYRRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-65 42
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-65 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 5e-66 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 5e-66 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA NP_960244.1 pyruvate kinase VFG0479 Protein 2e-66 42