Gene Information

Name : thyA (lpg2868)
Accession : YP_096862.1
Strain : Legionella pneumophila Philadelphia 1
Genome accession: NC_002942
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3245498 - 3246292 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAAACATATTTGCAATTGTTGGAGCATATTTTACAACATGGGGTAGAAAAATCCGATAGAACGGGCACTGGAACATT
ATCTGTATTTGGGTATCAAATGCGTTTTGATTTGGCCCAGGGATTCCCGCTTGTTACCACTAAAAAACTGCATACGAGAA
GTATTGTTCATGAATTACTGTGGTTCTTGCGTGGTGATACCAATATTTCTTATCTTAAGGAAAACGGGGTAACTATTTGG
GATGAATGGGCAGATAATAATGGTGATTTAGGGCCTGTCTATGGGAAGCAATGGAGAAGTTGGCCAACTGCTGATGGACG
CACCATTGATCAATTAAGTGAAGTAGTGCAACAAATAAAGAGCAACCCTGACTCTCGTCGCTTGATTGTAAGCGCCTGGA
ATGTGGGTGAATTGGATAAAATGGCTTTAATGCCTTGTCATGCCTTGTTTCAGTTTTATGTTGCAAACAACAAGCTATCC
TGTCAATTATATCAACGCTCAGCCGATGTATTTTTAGGAGTTCCTTTCAATATCGCTTCTTATTCGTTGCTTACTCATAT
GGTTGCTCAGCAATGTAATTTGGATGTGGCTGAATTTATATGGACCGGGGGAGATTGTCATTTGTATCTTAATCATTTGG
AGCAAGCGCAAATCCAATTAACAAGAGAACCTTTGCCATTGCCCTCCTTAGCTATTAAGAGAAAACCGGCTTCTTTATTT
GACTATGCTTATGAGGATTTTGAATTTTTGAATTATCAATCACATCCCGCAATTAAAGCGCCTATCGCCGTTTAA

Protein sequence :
MKTYLQLLEHILQHGVEKSDRTGTGTLSVFGYQMRFDLAQGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIW
DEWADNNGDLGPVYGKQWRSWPTADGRTIDQLSEVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLS
CQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQIQLTREPLPLPSLAIKRKPASLF
DYAYEDFEFLNYQSHPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 3e-86 65