Gene Information

Name : murD (lpg2616)
Accession : YP_096621.1
Strain : Legionella pneumophila Philadelphia 1
Genome accession: NC_002942
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 2952345 - 2953688 bp
Length : 1344 bp
Strand : -
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGAATCATTCCTTATATTTGGTAGCAGGGCTGGGTAAGACGGGACTCTCTATAGCAAGATACCTGAAGAGAAATAATAA
ATCGTTTGTTGTTTTTGATACACGTAAAGAGGCGCCTGGATTAGCTGAATTCCAAAATGAATTTCCTGATGTGCCAATTT
ACCTGCAACAGACTCCTGATGAAGTAATCAGCCAGGTGACGGATGTTATCACTAGCCCCGGTTTGGCACTGGATACGCCT
GTTTTAGAGAGAGCGCGTCAAGCGGGCGCATCAATTTATGGAGACATAGAATGCCTGGCCAGAGAGATTAGCGCCCCTGT
CATTGCCATAACGGGAACTAATGGTAAATCCACTGTAACGACTTTGGTGGGAGAAATGGCTAAGGCGGCCGGGTTTCGCG
TAGCTGTAGCCGGAAATATCGGCACTCCTGTCTTAGATATGTTGGATGATGAACATCACTACGATTTGTGGGTATTGGAG
TTATCCAGTTTTCAATTGGATTTAACTTATTCTTTGTCGCCAGTGGTTGCGACGATTCTTAATGTAACGCCTGATCATTT
GGACAGGCATCACACTATGGAAGCCTATACGCAAGCAAAACAAAGGATTTATCGTGGTGCCAAGGCTGTTTTATTTAATC
GTGAAGACGTCTACACTGTTCCTCACCAATCCTGTCAAGCAGATATAAAATGCATCTCTTTTGGCAAAGACGCGCCTTCA
ATGGGAAATTGGGGGCTGATTGAACAAGAGAATACTACTTATTTGGCGAAAGGAATGGAGCGTCTTTTGCCAGTGGAATC
GATTTTAATAAAAGGGGTGCATAATTGGATGAATGCGCTTGCTGCTTGTGCTTTAGCCGAAGCAGCGGGAATTTCTATGC
AACACATTCTTAATGTTTTAAAAACCTTCCCTGGACTGCCACATCGATGCCAGTGGGTAAGAGAAGTAGATGGAGTAGGT
TGGATTAATGATTCGAAAGGAACAAATATTGGTGCTACAATCTCTGCTATTAATGGAATAGGAGGTTCTATGCAAGGGAA
AATTGTTCTTATTGCGGGTGGACAGGGAAAAGGGGCGGATTTCCAAGAATTAGCCCAGCCAGTTTCAGAATTTGTTCGTT
CCATTGTTTTGATTGGTGAAGATGCTGACAAGATTGAATCGGCTTTAGCCAAAGTAGTTCCTGTCGTGCGTGCTTCTTCT
CTGGAGGGCGCTGTGACTATTGCCAAGACATGTGCGAAACCTGGTGATGTCGTTTTATTATCTCCAGCTTGTGCCAGTTT
GGATATGTTCCGTGATTTTAATCATAGGGGCGATGTGTTTACATCTTCAGTGCGCGGATTGTGA

Protein sequence :
MNHSLYLVAGLGKTGLSIARYLKRNNKSFVVFDTRKEAPGLAEFQNEFPDVPIYLQQTPDEVISQVTDVITSPGLALDTP
VLERARQAGASIYGDIECLAREISAPVIAITGTNGKSTVTTLVGEMAKAAGFRVAVAGNIGTPVLDMLDDEHHYDLWVLE
LSSFQLDLTYSLSPVVATILNVTPDHLDRHHTMEAYTQAKQRIYRGAKAVLFNREDVYTVPHQSCQADIKCISFGKDAPS
MGNWGLIEQENTTYLAKGMERLLPVESILIKGVHNWMNALAACALAEAAGISMQHILNVLKTFPGLPHRCQWVREVDGVG
WINDSKGTNIGATISAINGIGGSMQGKIVLIAGGQGKGADFQELAQPVSEFVRSIVLIGEDADKIESALAKVVPVVRASS
LEGAVTIAKTCAKPGDVVLLSPACASLDMFRDFNHRGDVFTSSVRGL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 2e-79 45
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 2e-79 45