Gene Information

Name : cadA-1 (lpg1009)
Accession : YP_095042.1
Strain : Legionella pneumophila Philadelphia 1
Genome accession: NC_002942
Putative virulence/resistance : Resistance
Product : cadmium translocating P-type ATPase CadA
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.1.-
Position : 1100463 - 1102652 bp
Length : 2190 bp
Strand : +
Note : -

DNA sequence :
GTGATGCCTCATTCATTGCAAGGGTTATATTTTACGGACAATGCGGAAAACCAAATGACAGTACCTTTAAATGAAATCAA
ATTTTTTGTTGCAGGACTTGATTGTCCAGCAGAAGAGCAGCTTATCAGAAAGCAGTTTCAGGATATTCCTGAAGTGGAGC
AGTTGGATTTTAATTTTATTGCTGAAGAAGTTACCATTCATCACCGGTTGGCTTCAAGTGAAGAATTGCAAAAACGCATT
GAGGTGTTGGGAATGAGTGTTCGAACGCTGGAAAGCACTTTACCTATACCACAAAGAAAACAATTATCGTTGGATTTTTC
CTGGAAAATTATTGGACTAGCAGGTTTTCTTGCCCTATTTTCTGAGCTGGCAGCTTATTTTTTGGCTACGGAACAATCCA
TTTGGACTATTCTTCCAGCTTTGTTGGCTATTGGTCTTAGTGGGCCTTCTACCTTTAAAAAAGGGTGGCTTGCCTTAGGG
ACTAAAACAATGAATATCAATAGCTTGATGTTCATTGCGATAGCAGGGGCTGTTCTTATTGGAGAGTGGCCTGAAGCGGC
AATGGTGACTGTTTTATTTGCATTGGCTGAACGTATCGAGCGCTACTCCTTAGATAAAGCACGTCTTGCGATTCGAAGCT
TAATGCAAATTGCCCCTGAGGTAGCTTCGGTGAAACAGGACGATGGTCAATGGCAAACCTTGGCCATTGAAAAAGTGGTG
CCTGGTGCTGTTTTTAGAGTAAAACCTGGAGAGCGTATTCCTCTGGATGGTGTTGTTATTTCAGGTCAGAGCACGGTCAA
TCAAGCGCCGATTACTGGTGAATCAATGCCAATAACAAAAAAAGTAGGCGATTTGGTTTTTGCAGGAACATTAAATGAGC
ACGGCGCGTTTGAAGTGCAGGTCAGTAAAGCGTCAGGCGATACATTGCTTGCTAAAATTGGTAAAGCGATAGAGCAAGCG
CAAGCGGATCGAGCCCCAACGCAACGATTTGTTGATCAATTTTCTAAATATTACACTCCAATTATGGTATTGATGGCTTT
TTTTGTTGCATTAATTCCACCTTTAGCATTTGGTTATCCTTTTTATGATTCTCTTTATAAGTCACTGACTTTATTAGTTA
TTGCTTGCCCTTGCGCTTTAGTGATTTCAACACCCGTGACTGTTGTAAGTGGCCTTGCAGCGGCAGCAAAACAAGGGCTT
CTTATTAAAGGAGGAAGCTACTTAGAGGTTGGTCATCGACTGAGGTTAATTGCTTTAGATAAGACAGGTACTTTAACGGA
AGGAAAGCCAGTTGTAACTGACTTCATAGCTTGGGATGAAAATCGAACTAAGGAGAGTTTGTTATTGTTAGCTGCAAGCC
TTGATAGTCACTCGGAGCATCCAGTCGCTAATGCCTTAGTACAGTACTGGCAACAGGAACAACCCCAAAACGCTTTACTT
GAAATTGAACAATTTTCAGCACTTCCTGGACGAGGAGTAAAAGGATTGGTGGGTCAAGAACTCTATTTTGTAGGCAATCA
TCAGTTAGCTGAAGACAATCAGGTATGCAATCATTTTGTCGAACAAGAGCTGAAGCGCTTGGAGGAAGAAGGTAAAACGA
CCGTAATATTAAGTAATGCTACGACGGTTTTGGCTATTTTTGCAGTAGCTGATACGTTACGTGTTACAAGCCAACAGGCG
ATTGCACAACTCCATGAACGGGGCATAAAAACCGCGATGTTAACGGGAGACAATGCGGTAACGGCTCAGGCTATTGCTAA
AAAAGTAGGTATTGATGAAGTAAATGCAAATATATTGCCTGCGGAAAAACTGCAAGCGATTAATCGTCTTTTAGAACACT
ATCATAGCGTTGGGATGGTAGGAGATGGAATTAATGATGCCCCTGCATTGGCAAAAGCTACCGTGAGTTTTGCGATGGGG
AAAGGAACAGATACTGCCTTAGAAACTGCTGACGTTGCCCTAATGAATGACAATCTAGCAAGACTTCCCTTTTATGTTGA
TTTAAGTCGTAAGACGGCACGTACTCTTTATCAAAACATCAGTTTATCTATTGCGATTAAAGGCATTTTCTTTATTTTAG
CTCTTGTAGGGTATGCAACGTTATGGATGGCAGTTTTTGCAGACATGGGAGCGAGTTTAATCGTAGTGGCTAATGGTTTG
CGATTGTTGTATATGTCTCCAGATGATTAA

Protein sequence :
MMPHSLQGLYFTDNAENQMTVPLNEIKFFVAGLDCPAEEQLIRKQFQDIPEVEQLDFNFIAEEVTIHHRLASSEELQKRI
EVLGMSVRTLESTLPIPQRKQLSLDFSWKIIGLAGFLALFSELAAYFLATEQSIWTILPALLAIGLSGPSTFKKGWLALG
TKTMNINSLMFIAIAGAVLIGEWPEAAMVTVLFALAERIERYSLDKARLAIRSLMQIAPEVASVKQDDGQWQTLAIEKVV
PGAVFRVKPGERIPLDGVVISGQSTVNQAPITGESMPITKKVGDLVFAGTLNEHGAFEVQVSKASGDTLLAKIGKAIEQA
QADRAPTQRFVDQFSKYYTPIMVLMAFFVALIPPLAFGYPFYDSLYKSLTLLVIACPCALVISTPVTVVSGLAAAAKQGL
LIKGGSYLEVGHRLRLIALDKTGTLTEGKPVVTDFIAWDENRTKESLLLLAASLDSHSEHPVANALVQYWQQEQPQNALL
EIEQFSALPGRGVKGLVGQELYFVGNHQLAEDNQVCNHFVEQELKRLEEEGKTTVILSNATTVLAIFAVADTLRVTSQQA
IAQLHERGIKTAMLTGDNAVTAQAIAKKVGIDEVNANILPAEKLQAINRLLEHYHSVGMVGDGINDAPALAKATVSFAMG
KGTDTALETADVALMNDNLARLPFYVDLSRKTARTLYQNISLSIAIKGIFFILALVGYATLWMAVFADMGASLIVVANGL
RLLYMSPDD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 4e-158 52
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-122 43
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 7e-121 42
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 6e-121 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA-1 YP_095042.1 cadmium translocating P-type ATPase CadA BAC0298 Protein 4e-156 52