Gene Information

Name : thyA (DIP0825)
Accession : NP_939189.1
Strain : Corynebacterium diphtheriae NCTC13129
Genome accession: NC_002935
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 797640 - 798452 bp
Length : 813 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAGCACCAACAACACCATAAAAACCCCGTATGAAGACCTTCTTCGCACAATCCTTGAACAGGGCTCCCACAAAGACGA
CCGTACCGGCACCGGTACAACCAGCCTTTTTGGCCAACAGATGCGTTTCGATCTCACCGAGGCCTTCCCACTCATCACCA
CCAAGAAGGTGTATTGGAAAGGTGTAATCGGAGAACTCCTCTGGTTCCTGCAAGGCTCCTCCAATGTTCGCTGGCTCCAA
AAGCGCAACATTCACATCTGGGATGAATGGGCTTCCGAAGAAGGCGAACTGGGACCTGTTTATGGTGTTCAATGGCGCAG
CTGGCCTACCCCTGATGGGCAGCATGTGGACCAGATCGCCCAAGCACTAGATATACTCAAAAACAATCCGGACTCTAGGC
GCAACATCGTCTCAGCGTGGAACGTGGCCGATCTCAACAATATGGCGCTTCCACCGTGCCACTTGTTGTTCCAGCTTTAT
GTTGCCGATGGAAAGTTGAGCTGCCAGCTCTACCAGCGCAGCGCAGACATGTTCTTAGGTGTTCCGTTTAATATCGCCTC
CTACTCCGCTCTCACACATATGCTCGCACAACAAGCAGGCCTTAAGGTCGGCGAGTTCATTTGGACTGGCGGCGACTGCC
ACATCTACGACAATCATCGCGAGCAGGTTCTCACCCAGCTCTCACGTGAACCTCGCCCCTACCCTCAGTTGACATTGCGG
AAAGCCTCCTCGATCTTCGACTACGACTTCGACGATTTCACTATCGAGGGCTACGATCCTCACCCAGCGATTCGTGGCGA
GGTAGCAGTGTAA

Protein sequence :
MSTNNTIKTPYEDLLRTILEQGSHKDDRTGTGTTSLFGQQMRFDLTEAFPLITTKKVYWKGVIGELLWFLQGSSNVRWLQ
KRNIHIWDEWASEEGELGPVYGVQWRSWPTPDGQHVDQIAQALDILKNNPDSRRNIVSAWNVADLNNMALPPCHLLFQLY
VADGKLSCQLYQRSADMFLGVPFNIASYSALTHMLAQQAGLKVGEFIWTGGDCHIYDNHREQVLTQLSREPRPYPQLTLR
KASSIFDYDFDDFTIEGYDPHPAIRGEVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 4e-105 78