Gene Information

Name : smpB (DIP0750)
Accession : NP_939123.1
Strain : Corynebacterium diphtheriae NCTC13129
Genome accession: NC_002935
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 726536 - 727027 bp
Length : 492 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCAAAGAAGAAAAAGGCGAAGAATAGCAACCCAGTTATTGCTTCTAACCGAAAAGCGCGGCATGACTACAAGATTTT
GGACACCTTCGAGTGTGGAATCGTGCTGTTGGGAACCGAAATCAAGTCGATCCGTGAGGGCAAAGTATCCCTCACCGACT
CCTTTGCCACTATCGATGAAGGCGAAGCCTGGATCCGTAATCTCAATATCCCAATCTATTCCCGCGGATCGTGGACGAAC
CACTCGCCAATGCGCACCCGAAAACTTCTTCTGCACCGACGCGAAATTGATTCGCTCATGGGCAAGGTGCGTGACGGAAA
CAAAACTCTGGTTCCATTGTCTTTGTACTTCAAAGAAGGGCGACTCAAAGTGGAACTCGGACTTGCTCAGGGTAAACAGG
ACTACGACAAACGCCAAGACATCAAGCGTCGCACCGAAGAACGAGAAGTGGTTCGCGATCTGGGGCGTCGTGTCAAGGGA
ATCCACGCTTAG

Protein sequence :
MAKKKKAKNSNPVIASNRKARHDYKILDTFECGIVLLGTEIKSIREGKVSLTDSFATIDEGEAWIRNLNIPIYSRGSWTN
HSPMRTRKLLLHRREIDSLMGKVRDGNKTLVPLSLYFKEGRLKVELGLAQGKQDYDKRQDIKRRTEEREVVRDLGRRVKG
IHA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 3e-54 73
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 6e-32 54
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 8e-23 43