Gene Information

Name : thiC (DIP0029)
Accession : NP_938438.1
Strain : Corynebacterium diphtheriae NCTC13129
Genome accession: NC_002935
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 27567 - 29366 bp
Length : 1800 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
GTGTCGGCAGCCTCAGCTAATTCAGTAACCAATCCATCTGCTTGGGAAAACTCCGAGATCCATCCGAAGCACTCGTATTC
GCCGATCGTTTCCGGTGACCTTGAGGTCCCAGAAACAGAGATTCAGCTTGACGATTCTCCTACCGGCCCCAATGATCCAG
TTCGGATCTATCGCACCCGTGGCCCTGAGTGTGATCCCACGGTGGGATTGAAGCCACTGCGTGCACAGTGGATTGATAGT
CGTGAGGACACGGAAGAATATGCTGGCCGTGAGCGGAATTTGGCTGATGATGGCCGCTCCGCGCAGCGTCGTGGCGCAGC
TTCGCTGGAGTGGAAAGGCGTGAAACCCACACCGCGACGCGCCAAGCAGGGCAAGCGCGTGACTCAGATGCACTATGCAC
GCCAGGGCATTATTACGAAGGAAATGGAGTTTGTGGCGCTGCGCGAGCACATGGACCCAGAGTTTGTGCGCAGCGAGATC
GCCCGTGGCCGTGCGATCATTCCGAACAACATTAACCACCCAGAATCGGAGCCCATGATTATTGGTCGAAAGTTTTTGAC
CAAGATCAACGCCAATATCGGTAACTCCGCAGTGACCTCCAGTATTGAGGAAGAAGTATCCAAGCTGCGGTGGGCTACCC
GCTGGGGTGCAGATACCGTGATGGATTTGTCCACCGGCGATGATATTCACACCACCCGCGAATGGATTATCCGCAACTCC
CCAGTACCAATCGGTACGGTGCCGATCTATCAAGCGCTGGAAAAAGTCAATGGTGTAGCAGAAGACCTTACGTGGGAGAT
TTTCCGCGATACCGTCATTGAGCAGTGTGAACAAGGTGTGGACTACATGACCATTCATGCCGGTGTGTTGCTCGCCTACA
TTCCACTGACCACCAAACGCATAACCGGAATTGTATCCCGTGGTGGATCCATCATGGCGGGTTGGTGCCTAGCTCACCAT
AAGGAGTCCTTCCTTTACGAGCACTTTGATGAGCTGTGCGAGATTTTCGCGCAGTACGACGTCGCCTTCTCGTTGGGTGA
TGGCCTGCGCCCTGGTTCTGTTGCCGATGCGAATGATGCGGCCCAGTTCGCGGAGCTGAAAACCATTGGTGAGCTGGCTC
GTCGTGCGTGGGAATACGATGTGCAGGTCATGATCGAGGGCCCAGGTCACGTTCCGCTGAACATGGTGCAGGAAAACAAT
GAGCTGGAGCAAAAGTGGGCTCACGATGCGCCTTTCTACACTCTTGGCCCATTGGTGACCGATATTGCGCCAGGCTATGA
CCACATCACCTCGGCAATTGGAGCTGCTCATATCGCTATGGGTGGTACGGCGATGCTGTGTTATGTGACCCCGAAGGAGC
ACTTGGGTCTGCCCAACCGTGACGATGTAAAAACCGGTGTGATTACTTATAAACTCGCAGCTCACGCGGCCGATGTGGCT
AAGGGGCACCCTGGTGCTCGTGCGTGGGATGACGCGATGAGCAAGGCACGTTTTGAGTTCCGTTGGCACGATCAGTTCGC
GTTGTCGCTTGATCCAGATACCGCGATTGCTTACCATGACGAAACGCTTCCGGCGGAGCCGGCAAAGACCGCGCACTTCT
GTTCCATGTGTGGTCCGAAGTTCTGCTCCATGCGCATTAGCCAAGATATTCGTGACATGTTCGCAGATAAGATCGCCGAC
TTGGGTATCCCGCAGGTTGGCGGCGACGCAGAAGCTGGTATGGCGGCAAAGTCTGAGGAGTTTGTGGCCCAAGGATCGCA
GCTTTATAGCGAGGTGCGTGACAATGCTGCCCACGCCTAG

Protein sequence :
MSAASANSVTNPSAWENSEIHPKHSYSPIVSGDLEVPETEIQLDDSPTGPNDPVRIYRTRGPECDPTVGLKPLRAQWIDS
REDTEEYAGRERNLADDGRSAQRRGAASLEWKGVKPTPRRAKQGKRVTQMHYARQGIITKEMEFVALREHMDPEFVRSEI
ARGRAIIPNNINHPESEPMIIGRKFLTKINANIGNSAVTSSIEEEVSKLRWATRWGADTVMDLSTGDDIHTTREWIIRNS
PVPIGTVPIYQALEKVNGVAEDLTWEIFRDTVIEQCEQGVDYMTIHAGVLLAYIPLTTKRITGIVSRGGSIMAGWCLAHH
KESFLYEHFDELCEIFAQYDVAFSLGDGLRPGSVADANDAAQFAELKTIGELARRAWEYDVQVMIEGPGHVPLNMVQENN
ELEQKWAHDAPFYTLGPLVTDIAPGYDHITSAIGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVA
KGHPGARAWDDAMSKARFEFRWHDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRDMFADKIAD
LGIPQVGGDAEAGMAAKSEEFVAQGSQLYSEVRDNAAHA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 1e-180 63
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 1e-180 63
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 3e-167 61