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Name : leuS (DIP2320) Accession : NP_940621.1 Strain : Corynebacterium diphtheriae NCTC13129 Genome accession: NC_002935 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 2421946 - 2424828 bp Length : 2883 bp Strand : - Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : TTGACCATGACTAATCCGAGCGGAAACACCCCTGACACTTCAGCAGGTCCTGCGTTTCGTTATACCGCCGAACTGGCCGG TGAGATCGAGCGTTCATGGCAGCAGTACTGGATTGATAACGGTACTTTTAACGCCCCCAACCCCGTGGGCGATTTAGCCG TCTCTGGAGACAAACTCCCTGAAGACAAGCTGTTTGTTCAGGATATGTTCCCGTATCCATCGGGTGCTGGTCTGCACGTT GGCCACCCACTGGGATACATTGCGACGGATGTTTTCGCTCGCTTTAACCGCATGCTAGGCAAGAATGTGCTGCACACCTT GGGCTACGATGCCTTCGGTCTGCCAGCTGAGCAGTATGCGATCCAGACGGGCACACACCCACGCACGACCACCATGGCCA ACATTGCGAACATGCAGCGCCAGTTGGGTGCATTGGGTTTGGGACACGATCCTCGCCGTAGCGTGGCTACCACTGATCCG GAGTTCTACAAGTGGACGCAGTGGATCTTCTTACAGATTTTCAATGCTTGGTTTGATACCAAGCAGCAAAAGGCCCGCCC TATCTCTGAGCTAATTCCGCTTCTGGAGTCGGGTGAAGTGGCATTGCCGGAGGGCTTCGAGGGCTCTGCTGACTCGTACT CCGAGTTGGATGCGGTGGAAAAAGCAAAGGTTGTGGATGAATTCCGCTTGGTTTACCGCTCTCACTCGATGGTGAACTGG TGCCCTGGTTTGGGCACTGTGTTGGCTAACGAGGAGGTCACCGCGGATGGTCGTTCGGAGCGCGGTAACTTCCCAGTTTT CCGCAAGAAGTTGTCGCAGTGGATGATGCGCATTACTGCATATTCGGATCGTCTTATCGACGACCTTGACCTGTTGGATT GGCCAGACAAGGTCAAGAGCATGCAGCGTAACTGGATTGGTCGTTCGCGTGGCGCTGAGGTGGACTTTGATGCCCTCGGC CACACGATCACCGTGTTCACCACCCGTCCAGACACACTGTTCGGCGCGTCCTACATGGTTCTCGCCCCTGAGCACGAGCT TGTCGACGCCCTCGTCGCCGCCGGCACGAACTCCTACGAAGGAATCGACCCCCGTTGGACCTTCGGCCAAGCCACCCCTG CGGAAGCAGTCAAAGCCTACCGTGCTTCCATCGCCGCAAAGAGCGACCTTGAGCGCCAAGAAAACAAGGAAAAGACAGGC GTTTACCTCGGCGTAAACGCCGTCAACCCTGTCAACGGTGAGAGCATCCCAGTGTTTATCGGTGACTATGTGCTCACCGG TTACGGCACCGGCGCAATCATGGCTGTGCCTGCACACGACACCCGCGATTACGAGTTCGCCACCGAATTCGGCCTGCCCA TTCGCGAGGTTGTCGCTGGCGGCAACATTGCCGAAGCGGCCTACACCGAATCCGGCGCAGCCGTGAACTCCGCTAATGAC CAAGGCCTCGATATCAATGGCCTAGACAAGCAGGAAGCGATTGCTCAGGTTATTGAGTGGCTCGTCGACAAGCAAAAGGG ATCCGAAAAAATCCAGTACAAGCTGCGCGACTGGCTCTTCGCCCGCCAGCGCTACTGGGGCGAACCATTCCCAGTCGTCT ACGACGAAAACGGCCTCGCCCACGCACTACCCGAATCCATGCTGCCCGTCGAACTCCCCGAGGTAGAAGACTACAAACCA GTCTCCTTCGACCCAGACGACGCCGACTCCGAACCACACCCACCACTGGCCAAAGCCACCGAGTGGACCCAAGTAGAACT CGACCTCGGCGACGGCCTGAAGAAGTACACCCGCGACACCAACGTCATGCCACAGTGGGCCGGCTCCTCCTGGTACCAAC TGCGCTACATCGACCCCACCAACAGCGAAGCTTTCTGCGACATCGAAAACGAACGCTACTGGACAGGCCCCCGCAGCGCA GAAGACTCCGGCGGCGTTGACCTCTACGTCGGCGGCGTCGAGCACGCCGTGCTCCACCTCTTGTACTCCCGCTTCTGGCA CAAAGTCCTCTTCGACCTCGGCTTTGTTACCTCCCGCGAACCTTACCGACGCCTCTTCAACCAAGGCTACATCCAAGCAT TTGCCTACACCGACTCCCGTGGCGTGTACGTCCCAGCCGAAGAAGTAGAAGAAAAAGACGGCAAATTCTACTACCAAGGC GAAGAAGTCAACCAGGAATACGGCAAGATGGGCAAGTCCCTCAAGAACGCCGTCGCACCTGACGACATCTGCCGCGACTT CGGCGCCGACACCCTCCGCGTCTACGAAATGGCCATGGGACCACTGGACACCTCTCGCCCATGGTCTACCAAGGACGTCA TCGGTGCCCACCGCTTCCTCCAGCGACTCTGGCGCCTCGTGGTCTCGGAAGACGATGGCTCCATCGTTGTCACCGACGCA GCACTCACCGACGACGACCTCAAGCAACTACACCGCACCATCGCCGGCATGCGTGACGACTACGAAGGCCTGCGCATCAA CACCGTGGTAGCCAAAGCCATCGAATACGTCAACTACCTGACCAAGGCATACGGCTCCACCGGTGCACCACGCGCAGCCG TCGAACCACTGGTCATCATGGTCGCAGCCGTCGCACCACACATCGCCGAAGAGCTCTGGAAGCGCCTCGGACACAACGAC ACCATCACCTTTGTCCCCTTCCCCGAGTACGAAGACAAGTGGCTCGTTGACGACGAAGTAGAAATGCCAGTCCAGATCAA CGGCAAGGTCCGCGCCCGCATCATGGTCCCTGCCGACGCCTCCCAAGACCAGATCTCCGAAATCGCACTCGCCTCCGAGG CCGTGGCAACACACATCGAAGGCAAGAACGTGATCAAGAAGATCGTCGTCTCAGGGCGCATGGTCAACCTAGTGGTCAAG TAA Protein sequence : MTMTNPSGNTPDTSAGPAFRYTAELAGEIERSWQQYWIDNGTFNAPNPVGDLAVSGDKLPEDKLFVQDMFPYPSGAGLHV GHPLGYIATDVFARFNRMLGKNVLHTLGYDAFGLPAEQYAIQTGTHPRTTTMANIANMQRQLGALGLGHDPRRSVATTDP EFYKWTQWIFLQIFNAWFDTKQQKARPISELIPLLESGEVALPEGFEGSADSYSELDAVEKAKVVDEFRLVYRSHSMVNW CPGLGTVLANEEVTADGRSERGNFPVFRKKLSQWMMRITAYSDRLIDDLDLLDWPDKVKSMQRNWIGRSRGAEVDFDALG HTITVFTTRPDTLFGASYMVLAPEHELVDALVAAGTNSYEGIDPRWTFGQATPAEAVKAYRASIAAKSDLERQENKEKTG VYLGVNAVNPVNGESIPVFIGDYVLTGYGTGAIMAVPAHDTRDYEFATEFGLPIREVVAGGNIAEAAYTESGAAVNSAND QGLDINGLDKQEAIAQVIEWLVDKQKGSEKIQYKLRDWLFARQRYWGEPFPVVYDENGLAHALPESMLPVELPEVEDYKP VSFDPDDADSEPHPPLAKATEWTQVELDLGDGLKKYTRDTNVMPQWAGSSWYQLRYIDPTNSEAFCDIENERYWTGPRSA EDSGGVDLYVGGVEHAVLHLLYSRFWHKVLFDLGFVTSREPYRRLFNQGYIQAFAYTDSRGVYVPAEEVEEKDGKFYYQG EEVNQEYGKMGKSLKNAVAPDDICRDFGADTLRVYEMAMGPLDTSRPWSTKDVIGAHRFLQRLWRLVVSEDDGSIVVTDA ALTDDDLKQLHRTIAGMRDDYEGLRINTVVAKAIEYVNYLTKAYGSTGAPRAAVEPLVIMVAAVAPHIAEELWKRLGHND TITFVPFPEYEDKWLVDDEVEMPVQINGKVRARIMVPADASQDQISEIALASEAVATHIEGKNVIKKIVVSGRMVNLVVK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 4e-149 | 48 |
