Gene Information

Name : clpC (DIP1983)
Accession : NP_940314.1
Strain : Corynebacterium diphtheriae NCTC13129
Genome accession: NC_002935
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease ATP-binding subunit
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2030233 - 2032884 bp
Length : 2652 bp
Strand : -
Note : Similar to Bacillus subtilis negative regulator of genetic competence ClpC SW:CLPC_BACSU (P37571) (810 aa) fasta scores: E(): 2.6e-134, 58.11% id in 826 aa, and to Mycobacterium tuberculosis probable ATP-dependent Clp protease ATP-binding subunit Rv3596c

DNA sequence :
TTGAAGGGTGTGAACATGTTCGAGCGGTTTACCGATCGTGCACGTCGCGTTATCGTTCTGGCACAGGAAGAAGCGCGCGG
CCTCAATCACAATTACATCGGCACCGAGCACATCCTGCTCGGACTTATTCACGAGGGTGAGGGCGTGGCCGCTAAGGCGC
TCGAGTCCATGGGCATCTCCCTTGAAGCAGTACGCCAAGAGGTAGAAGAAATCATCGGCCACGGCTCCGAGCCACCAGCT
GGCCACATTCCTTTTACTCCACGTGCCAAGAAGGTACTTGAGCTCTCCTTGCGTGAGGGTCTGCAGATGGGACATAAGTA
CATCGGTACTGAGTTCCTGCTGCTCGGCCTTATCCGTGAGGGCGACGGCGTAGCCGCACAAGTTTTGGTCAAGCTCGGCG
CTGACCTGCCCCGTGTACGCCAGCAGGTTATCCAGCTTCTTTCCGGCTATGAGGGGGGCGAAAGCCCAGAAAACAATAAC
GAGGGCGAGGCTGTGGGTGCTGGTACTGGCGCTGGCCGTGCTGGCCGCGGTGGTGGCGCAGGCGAGCGCTCCAACTCCTT
GGTTTTGGACCAGTTTGGTCGCAACCTCACCCAGGCTGCTAAGGAAGGCAAGCTGGATCCTGTGGTGGGTCGTGAGCAGG
AAATTGAGCGCATCATGCAGGTGCTCTCACGTCGTACCAAGAACAACCCAGTTCTTATCGGTGAGCCAGGTGTTGGTAAG
ACCGCTGTTGTAGAAGGCCTAGCTCTAGACATCGTTAACGGCAAGGTGCCAGAAACGCTGAAAGACAAGCAGGTTTACTC
TCTTGACCTCGGCTCCTTGGTGGCAGGTTCGCGCTACCGTGGTGACTTCGAAGAGCGCCTGAAGAAGGTTCTCAAGGAGA
TCAACCAGCGTGGCGACATCATCTTGTTCATCGATGAGATCCACACCCTCGTCGGTGCCGGTGCCGCAGAAGGCGCTATC
GACGCTGCCAGCTTGCTCAAACCTAAACTGGCTCGTGGTGAGCTACAGACCATCGGTGCTACCACTTTGGACGAGTACCG
CAAGCACATCGAAAAGGACGCCGCACTTGAGCGTCGTTTCCAGCCAGTGCAGGTTCCAGAGCCTTCCGTCGATATGACCA
TCGAGATCCTCAAGGGGCTACGCGACCGCTACGAGGCACACCACCGCGTCTCCATCACCGATGGGGCTCTCGCAGCAGCA
GCACAGCTGTCCGATCGCTACATCAACGATCGCTTCTTGCCAGATAAGGCTGTTGACCTTATCGACGAAGCCGGCGCACG
CATGCGTATCAAGCGCATGACCGCACCGGAATCCATCCGCAAGGTAGACGATCAGATCGCGGAAGTCCGTCGTGAGAAGG
AAGCCGCAATCGATGCCCAAGACTTTGAAAAGGCCGCTGGCCTGCGCGACACCGAGCGCAAGTTAGGTGAAGAGCGCGCT
GAGAAAGAAAAGCAGTGGCGCTCCGGCGACCTAGAAGACATCGCCGAGGTCGGCGAGGAGCAAATCGCTGAGGTGCTGGG
CAACTGGACTGGTATCCCAGTGTTCAAGCTGACCGAGGAAGAATCCTCCCGTCTGCTGCACATGGAAGAGGAGCTACACA
AGCGCATCATCGGCCAAGACGATGCCGTCAAGAGTGTTTCTCGCGCCATCCGCCGCACCCGCGCTGGCCTCAAGGACCCA
CGCCGTCCTTCCGGCTCCTTCATCTTCGCCGGCCCATCTGGCGTGGGTAAGACCGAGCTATCCAAGTCACTGGCCAACTT
CCTGTTCGGCGACGACGACGCCCTAATCCAGATCGACATGGGCGAGTTCCACGACCGCTTCACCGCGTCCCGTCTGTTCG
GTGCCCCTCCAGGATATGTGGGCTACGACGAGGGCGGTCAGCTCACCGAGAAGGTCCGCCGCAAGCCATTCTCCGTGGTG
CTTTTCGACGAAATCGAAAAGGCGCACAAGGAGATCTACAACACCTTGCTGCAGGTCCTCGAAGAAGGTCGCCTCACCGA
CGGCCAAGGCCGCGTGGTGGACTTCAAGAACACCGTGCTGATCTTCACCTCCAACCTGGGTACCCAAGACATCTCTAAGG
CTGTGGGCATGGGCTTTAGCTCTGTCGGCGAGCACGATGCCGATGGCCAGTACGACCGCATGAAGCAGAAGGTCAACGAC
GAGCTAAAGAAGCACTTCCGCCCTGAGTTCCTCAACCGTATCGACGAAATCGTGGTATTCCACCAGCTCACCCAAGAGCA
GATCGTCGAAATGGTGGACCTGCTCATCGGACGCGTATCCAAGGCACTTGCTCAAAAAGACATGGGCATCGAGCTCACCG
AAAAGGCCAAGAACCTGCTGGCAAAGCGTGGATTCGATCCAGTACTGGGTGCACGACCATTGCGTCGCACCATCCAGCGC
GAGATCGAAGACGTACTCTCCGAGAAGATCCTCTTCGGTGAGGTCGGCGCTGGTGAGATCGTCACCGTGGATGTTGAAGG
CTGGGACGGCGAATCCAAGGAAACCGACAAGGCTTCCTTCACCTTCACCCCACGCGTGAAGCCGCTGCCAGACGAGTTCG
AAGAGGCAACCCCATCTGAGGAAGCTCAAGAAGCAGTGATTAACGCTGCTGAGACTGAGGTTCCAGAAGAAGAAGTCAAC
ATCGAAAACTAA

Protein sequence :
MKGVNMFERFTDRARRVIVLAQEEARGLNHNYIGTEHILLGLIHEGEGVAAKALESMGISLEAVRQEVEEIIGHGSEPPA
GHIPFTPRAKKVLELSLREGLQMGHKYIGTEFLLLGLIREGDGVAAQVLVKLGADLPRVRQQVIQLLSGYEGGESPENNN
EGEAVGAGTGAGRAGRGGGAGERSNSLVLDQFGRNLTQAAKEGKLDPVVGREQEIERIMQVLSRRTKNNPVLIGEPGVGK
TAVVEGLALDIVNGKVPETLKDKQVYSLDLGSLVAGSRYRGDFEERLKKVLKEINQRGDIILFIDEIHTLVGAGAAEGAI
DAASLLKPKLARGELQTIGATTLDEYRKHIEKDAALERRFQPVQVPEPSVDMTIEILKGLRDRYEAHHRVSITDGALAAA
AQLSDRYINDRFLPDKAVDLIDEAGARMRIKRMTAPESIRKVDDQIAEVRREKEAAIDAQDFEKAAGLRDTERKLGEERA
EKEKQWRSGDLEDIAEVGEEQIAEVLGNWTGIPVFKLTEEESSRLLHMEEELHKRIIGQDDAVKSVSRAIRRTRAGLKDP
RRPSGSFIFAGPSGVGKTELSKSLANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYDEGGQLTEKVRRKPFSVV
LFDEIEKAHKEIYNTLLQVLEEGRLTDGQGRVVDFKNTVLIFTSNLGTQDISKAVGMGFSSVGEHDADGQYDRMKQKVND
ELKKHFRPEFLNRIDEIVVFHQLTQEQIVEMVDLLIGRVSKALAQKDMGIELTEKAKNLLAKRGFDPVLGARPLRRTIQR
EIEDVLSEKILFGEVGAGEIVTVDVEGWDGESKETDKASFTFTPRVKPLPDEFEEATPSEEAQEAVINAAETEVPEEEVN
IEN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 99
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 3e-98 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC NP_940314.1 ATP-dependent Clp protease ATP-binding subunit VFG0079 Protein 0.0 58
clpC NP_940314.1 ATP-dependent Clp protease ATP-binding subunit VFG0080 Protein 4e-150 50