Gene Information

Name : tpx (DIP1362)
Accession : NP_939715.1
Strain : Corynebacterium diphtheriae NCTC13129
Genome accession: NC_002935
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 1380544 - 1381041 bp
Length : 498 bp
Strand : -
Note : Similar to Escherichia coli thiol peroxidase Tpx or B1324 or Z2452 or ECS1903 SWALL:TPX_ECOLI (SWALL:P37901) (167 aa) fasta scores: E(): 5.8e-35, 61.11% id in 162 aa, and to Pseudomonas aeruginosa probable thiol peroxidase Tpx or PA2532 SWALL:TPX_PSEAE (S

DNA sequence : 
ATGGCTATTACACATTTTCAAGAATCAGCGGTAGAAACTAGCGGATCTCTTCCACAAGTTGGGCAGGCTCTTCCGCCTTT
CCTTCTCGTCGACGCAGATTTAACTGATTTTGATGCTGAGCGTTTTGCTGGCAAAAAGATTATTCTCAACATTTTCCCAT
CCATTGATACTGGTGTTTGCGCGCAATCAGTGCGGCACTTTAACAAGGAAGCAGCTGATTTAGCTGACACTGTGGTGATT
TGTGCATCTGCGGATCTACCATTTGCACATTCTCGTTTCTGTGCTGCTGAGGGTCTCGATAATGTCATTACGGGATCATC
ATTCCGTTCTTCTTTTGGTCAAGACTATGGAGTTGTTCTCGAGGGATCACCGTTGAAGGGCTTGTTAGCCCGTGCCGTCA
TCGTTGCTGATGAGCAAGGTACTGTTGTTCATTCCCAGTTGGTCGATGAGATCACGACTGAGCCTGATTATGCTGCTGCT
TTGGCATCCATCAAGTAA

Protein sequence : 
MAITHFQESAVETSGSLPQVGQALPPFLLVDADLTDFDAERFAGKKIILNIFPSIDTGVCAQSVRHFNKEAADLADTVVI
CASADLPFAHSRFCAAEGLDNVITGSSFRSSFGQDYGVVLEGSPLKGLLARAVIVADEQGTVVHSQLVDEITTEPDYAAA
LASIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 1e-37 53
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-37 53
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 8e-38 53
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-37 53

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx NP_939715.1 thiol peroxidase VFG0087 Protein 7e-38 53