Gene Information

Name : kpsU (CT1830)
Accession : NP_662709.1
Strain : Chlorobium tepidum TLS
Genome accession: NC_002932
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 1735251 - 1735997 bp
Length : 747 bp
Strand : -
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGAACGCCGTCATCGTCATTCCCGCCCGTCTTAGCTCCAGCCGTCTGAAAGAGAAAATGCTTGCCGATCTCGAAGGCGA
GCCGCTCATCGTGCGCACCTGGCAGCAAGCGACGAAATCGCGCCTTGCGAGCCGCGTGGTGGTGGCGACCGACAGCGAGC
GCATCTTTGCGGTGCTTCGCGAGGCCGGCGCGGAGGTGGTGATGACCTCGCCTGACCTCACCTGCGGCACCGACCGCATC
GCCGAGGCCGCTGAACAGGTGGGTGGCGACGTATTCGTCAATCTCCAGGGCGACGAACCACTCATCGACCCGGCGACTAT
CGACCTTGCCATCGCGCCCTTTTTCGGGGAGGGCCCGCTGCCCGACTGCACCACCCTGGTTTTCCCGCTCAAGCCTGATG
AACGGCAGATCATCGACGATCCACACGTGGTCAAGGCCGTGCTCGACACTCGCGGCAATGCGCTCTACTTCTCGCGCAGC
CCGATTCCGTACCGCCGTGAAACCCTGCCCGATACGAAATACTACCGCCACATCGGCCTCTACGCCTTCCGCGCCGACGT
GCTCAAAGCCTTCGTTGCGCTCCCGCCCTCGATGCTCGAACGCGCCGAATCCCTCGAACAACTCCGCCTCCTCGAAAACG
GCTACCGCATTCGCTGCATCGAAACAACGACGGATACGCCGGGCGTGAACACCGAGGAGGAGCTGGAAGAGGTGCGCAGG
CTGTTCAGGGAGCGGTTTGGAGCGTGA

Protein sequence :
MNAVIVIPARLSSSRLKEKMLADLEGEPLIVRTWQQATKSRLASRVVVATDSERIFAVLREAGAEVVMTSPDLTCGTDRI
AEAAEQVGGDVFVNLQGDEPLIDPATIDLAIAPFFGEGPLPDCTTLVFPLKPDERQIIDDPHVVKAVLDTRGNALYFSRS
PIPYRRETLPDTKYYRHIGLYAFRADVLKAFVALPPSMLERAESLEQLRLLENGYRIRCIETTTDTPGVNTEEELEEVRR
LFRERFGA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 8e-39 44
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 6e-39 44
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 3e-39 44